Libexin flour syrup 5%, 125ml

• Acute and chronic bronchopulmonary diseases, accompanied by the formation of viscous, difficult to separate sputum (tracheitis, bronchitis, tracheobronchitis, bronchial asthma, bronchiectasis) and mucus (inflammatory diseases of the middle ear, nose and its paranasal sinuses - rhinitis, otitis media, sinusitis).

• Preparing the patient for bronchoscopy or bronchography.

Inside.
One measuring cup of syrup (15 ml) contains 750 mg of carbocisteine. Take one measuring cup (15 ml) 3 times a day, preferably separately from meals. The duration of treatment should not exceed 8 days.

100 ml of syrup contains:

Active substance:

Carbocisteine ??5.0000 g

Excipients:

Sucrose 40.0000 g

Methyl parahydroxybenzoate 0.1500 g

Caramel color, powder (E 150) 0.0344 g

Cinnamon oil 0.0020 g

Aromatic elixir * 2 ml

Sodium hydroxide qs to pH 6.10 - 6.30

Purified water qs up to 100 ml

* - aromatic elixir (55.3% ethyl alcohol, 42.7% rum, 2.0% aromatic additive 'rum').

One measuring cup (15 ml) of syrup contains 750 mg of carbocysteine, 6 g of sucrose, 0.2 g of ethanol and 97 mg of sodium. Alcohol content (v / v): 1.64 ?.

• Hypersensitivity to carbocisteine ??or other components of the drug.

• Peptic ulcer and duodenal ulcer in the acute stage.

• Chronic glomerulonephritis (in the acute phase), cystitis.

• Pregnancy.

• Children under 15 years of age.

Carefully

History of gastric ulcer and duodenal ulcer, lactation period.

Trade name of the drug : Libexin MukoЃ.

International non-proprietary name : carbocisteine.

Dosage form : syrup.

Composition:

100 ml of syrup contains:

Active substance:

Carbocisteine ??5.0000 g

Excipients:

Sucrose 40.0000 g

Methyl parahydroxybenzoate 0.1500 g

Caramel color, powder (E 150) 0.0344 g

Cinnamon oil 0.0020 g

Aromatic elixir * 2 ml

Sodium hydroxide qs to pH 6.10 - 6.30

Purified water qs up to 100 ml

* - aromatic elixir (55.3% ethyl alcohol, 42.7% rum, 2.0% aromatic additive 'rum').

One measuring cup (15 ml) of syrup contains 750 mg of carbocysteine, 6 g of sucrose, 0.2 g of ethanol and 97 mg of sodium. Alcohol content (v / v): 1.64 ?.

Description

Syrupy liquid from brownish-yellow to light brown with the smell of rum and cinnamon.

Pharmacotherapeutic group

Expectorant mucolytic agent.

pharmachologic effect

Carbocisteine, being a mucolytic, acts on the gel phase of endobronchial secretion, breaking the disulfide bridges of glycoproteins and, thus, decreasing the viscosity and increasing the elasticity of the secretion. Carbocisteine ??activates sial transferase - an enzyme of the goblet cells of the bronchial mucosa, normalizes the quantitative ratio of acidic and neutral sialomucins, promotes the regeneration of the mucous membrane, normalizes its structure, activates the activity of the ciliated epithelium, restores the secretion of immunologically active IgA (specific protection), improves mucociliary clearance.

Pharmacokinetics

Carbocisteine ??is rapidly absorbed after oral administration, reaching a maximum serum level after 2 hours. Bioavailability is low (less than 10% of the dose taken) as a result of possible rapid passage through the liver. The half-life is about 2 hours. It is excreted mainly by the kidneys along with metabolites.

Indications for use

• Acute and chronic bronchopulmonary diseases, accompanied by the formation of viscous, difficult to separate sputum (tracheitis, bronchitis, tracheobronchitis, bronchial asthma, bronchiectasis) and mucus (inflammatory diseases of the middle ear, nose and its paranasal sinuses - rhinitis, otitis media, sinusitis).

• Preparing the patient for bronchoscopy or bronchography.

Contraindications

• Hypersensitivity to carbocisteine ??or other components of the drug.

• Peptic ulcer and duodenal ulcer in the acute stage.

• Chronic glomerulonephritis (in the acute phase), cystitis.

• Pregnancy.

• Children under 15 years of age.

Carefully

History of gastric ulcer and duodenal ulcer, lactation period.

Method of administration and dosage

Inside.
One measuring cup of syrup (15 ml) contains 750 mg of carbocisteine. Take one measuring cup (15 ml) 3 times a day, preferably separately from meals. The duration of treatment should not exceed 8 days.

Side effect

From the gastrointestinal tract: sometimes there is nausea, vomiting, diarrhea, epigastric pain, gastrointestinal bleeding.
Allergic reactions: itching, urticaria, exanthema, angioedema.
Others: dizziness, weakness, malaise.

Overdose

Symptoms: gastralgia, nausea, diarrhea. Treatment is symptomatic.

Interaction with other medicinal products

Carbocisteine ??increases the effectiveness of glucocorticosteroid and antibacterial therapy of inflammatory diseases of the upper and lower respiratory tract, potentiates the bronchodilator effect of theophylline. The activity of carbocisteine ??is weakened by antitussives and atropine-like drugs.
Due to the alcohol content, Libexin Muko is prescribed with caution with the following drugs:

• drugs that cause adverse reactions (fever, redness, vomiting, tachycardia) when taken simultaneously with alcoholic beverages: disulfiram, cefamandol, cefoperazone, latamoxef (cephalosporin antibiotics), chloramphenicol (a phenicol antibiotic), chlorpropamide, glitamibenclamide drugs ), griseofulvin (antifungal drug), nitro-5-imidazoles (metronidazole, ornidazole, secnidazole, tinidazole), ketoconazole, procarbazine (cytostatic);

• drugs that depress the central nervous system.

special instructions

The alcohol content in the preparation is 1.64 ?, that is, 0.2 g of alcohol per measuring cup. May be dangerous for people with liver disease, alcoholism, epilepsy, trauma or brain disease, and pregnant women.
When prescribing Libeksin Muko to patients with diabetes mellitus or patients on a low-carbohydrate diet, the sucrose content (6 g) per measuring cup should be taken into account.
When patients are following a salt-free or low-salt diet, the sodium content (97 mg) per measuring cup should be taken into account.

Impact on the ability to drive vehicles and work on machine tools

Violation of the speed of psycho-motor reactions associated with the presence of alcohol in the drug can be dangerous when driving a car or working on machines.

Release form

Syrup 50 mg / ml.
125 ml, 200 ml or 300 ml each in a colorless glass bottle (type III), closed with an aluminum screw cap with first opening control. 1 bottle with a measuring cup and instructions for use in a cardboard box.

Storage conditions

Store at a temperature not exceeding 25 ? C. Keep out of the reach of children.

Shelf life

3 years.
Do not use after the expiration date.

Conditions of dispensing from pharmacies

Available without a prescription.