Levomycetin solution 1%, 25 ml

Levomycetin solution 1%, 25 ml; 'For external use: in the second phase of the wound process (absence of pus, necrotic tissue), long-term non-healing trophic ulcers, burns of II-III degree

When applied externally, apply to gauze swabs or directly to the affected area. A regular bandage is applied on top, it is possible with parchment or compress paper. Dressings are made, depending on the indications, after 1-3 days, sometimes after 4-5 days

Solution for external use alcoholic transparent, colorless or with a yellowish tinge, with a characteristic smell of alcohol.

100 ml

chloramphenicol 0.25 g

Excipients: ethanol 70% up to 100 ml.

Hypersensitivity to chloramphenicol, inhibition of bone marrow hematopoiesis, acute intermittent porphyria, deficiency of glucose-6-phosphate dehydrogenase, hepatic and / or renal failure, pregnancy, lactation period; psoriasis, eczema, fungal skin lesions; Phase I of the wound process (due to the lack of osmotic activity),

Carefully

Early childhood, patients previously treated with cytostatic drugs or radiation therapy.

pharmachologic effect

Broad-spectrum antibiotic. The mechanism of antimicrobial action is associated with a violation of protein synthesis in a microbial cell at the stage of transfer of t-RNA amino acids to ribosomes. Has a bacteriostatic effect. Active against gram-positive bacteria: Staphylococcus spp., Streptococcus spp .; gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Haemophilus influenzae, Salmonella spp., Shigella spp., Klebsiella spp., Serratia spp., Yersinia spp., Proteus spp., Rickettsia spp .; also active against Spirochaetaceae, some large viruses. Chloramphenicol is active against strains resistant to penicillin, streptomycin, sulfonamides. The resistance of microorganisms to chloramphenicol develops relatively slowly.

Pharmacokinetics

When applied externally, absorption is negligible.

Side effect

Local reactions: itching, redness, skin manifestations of allergic reactions, angioedema.

Application during pregnancy and lactation

Chloramphenicol is contraindicated for use during pregnancy and lactation (breastfeeding).

Application for violations of liver function

Contraindicated in severe liver dysfunction.

Application for impaired renal function

Use is contraindicated in severe renal impairment.

Application in children

Chloramphenicol is not used in newborns, because development of 'gray syndrome' (flatulence, nausea, hypothermia, gray-blue skin color, progressive cyanosis, dyspnea, cardiovascular failure) is possible.

Use in elderly patients

Use with caution in elderly patients in order to avoid exacerbation of chronic diseases.

special instructions

Chloramphenicol is not used in newborns, because development of 'gray syndrome' (flatulence, nausea, hypothermia, gray-blue skin color, progressive cyanosis, dyspnea, cardiovascular failure) is possible. Use with caution in patients who have previously received treatment with cytostatic drugs or radiation therapy. In the course of treatment, systematic monitoring of the peripheral blood picture is necessary. It is unacceptable for the uncontrolled prescription of chloramphenicol and its use in mild forms of infectious processes, especially in pediatric practice.