Levofloxacin | Levostar tablets coated.pl.ob. 500 mg 10 pcs.
Special Price
$16.56
Regular Price
$27.00
In stock
SKU
BID477245
Release form
Levostar tablets, film-coated in pink, oval, biconvex, with a notch on one side and an engraving L on the other.
Levostar tablets, film-coated in pink, oval, biconvex, with a notch on one side and an engraving L on the other.
Release form
Levostar tablets, film-coated in pink, oval, biconvex, with a notch on one side and an engraving L on the other.
Pharmacological action
Levofloxacin is a broad-spectrum antibiotic from the group of fluoroquinolones, containing as active substance levorotatory ofloxacin isomer. It blocks DNA gyrase (topoisomerase II) and topoisomerase IV, disrupts supercoiling and cross-linking of DNA breaks, inhibits DNA synthesis, and causes deep morphological changes in the cytoplasm, cell wall and membranes.
Effective against most strains of microorganisms both in vitro and in vivo. By the action of the drug sensitive:
- Gram positive microorganisms - Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes and Streptococcus agalactiae, Viridans group streptococci
- Gram-negative organisms - Enterobacter cloacae, Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter sakazakii, Escherichiacoli, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Klebsiella oxytoca, Legionella pneumoniae, Moraxella catarrhalis, Proteus mirabilis, Pseudomonas aeruginosa, Pseudomonas fluorescens, Acinetobacter anitratus, Acinetobacter baumannii, Acinetobacter calcoaceticus, Bordetella pertussis, Citrobacter diversus, Citrobacter freundii, Proteus vulgaris, Providencia rettgeri, Providencia stuartii , Serratia marcescens
are also sensitive anaerobic microorganisms (Clostridiumperfringens, Bacteroides fragilis) and other groups of microorganisms - Chlamydia pneumoniae, Mycoplasma pneumoniae, Mycobacterium tuberculosis.
Indications
Infectious and inflammatory diseases caused by microorganisms sensitive to the drug: - lower respiratory tract infections (exacerbation of chronic bronchitis, community-acquired pneumonia)
- infections of the ENT organs (acute sinusitis)
- infections of the urinary tract and kidneys acute pyelonephritis)
- infections of the genital organs (including bacterial prostatitis)
- infections of the skin and soft tissues (suppurating atheromas, abscesses, boils)
- intra-abdominal infections
- tuberculosis (complex erapiya drug-resistant forms).
Contraindications
- epilepsy
- tendon damage with previous treatment with quinolones
- pregnancy
- lactation period
- childhood and adolescence (up to 18 years)
- lactose intolerance, lactose intolerance, lactose intolerance, glucose-galactose malabsorption
- hypersensitivity to levofloxacin or other fluoroquinolones, as well as to excipients of the drug Levostar.
Precautions: old age (due to the high likelihood of a concomitant decrease in renal function), glucose-6-phosphate dehydrogenase deficiency
Special instructions
Levofloxacin should be used at least 2 hours before or 2 hours after taking preparations of salts of iron, zinc, antacids and sucralfate.
During treatment, it is necessary to avoid solar and artificial UV radiation in order to avoid damage to the skin (photosensitivity).
When signs of tendonitis, pseudomembranous colitis appear, Allergic reactions Levofloxacin is immediately canceled.
It should be borne in mind that in patients with a history of brain damage (stroke, severe trauma), seizures may develop, with glucose-6-phosphate dehydrogenase deficiency, there is a risk of hemolysis.
Effect of Levostarf on the ability to drive vehicles and control mechanisms
During treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Composition
1 tablet: - levofloxacin hemihydrate 256.23 mg, respectively. the content of levofloxacin 250 mg
- levofloxacin hemihydrate 512.46 mg, respectively. levofloxacin 500 mg
Excipients: sodium stearyl fumarate, crospovidone (polyplasdone XL), anhydrous silicon dioxide colloidal (Aerosil 200), copovidone (Plasdon S-630), microcrystalline cellulose.
Film composition: Opadry II pink 31K34554 (lactose monohydrate, HPMC 2910 / hypromellose 15cP, titanium dioxide, triacetin, iron oxide red, iron oxide yellow).
Dosage and administration
Inside, during meals or between meals, without chewing, with plenty of fluids.
Doses are determined by the nature and severity of the infection, as well as the sensitivity of the suspected pathogen,
Recommended dose of Levostar for adults with normal renal function (CC> 50 ml / min): In acute sinusitis - 500 mg 1 time per day for 10-14 days
In case of exacerbation of chronic bronchitis - from 250 to 500 mg 1 time per day for 7-10 days
In community-acquired pneumonia - 500 mg of Levostar 1 or 2 times a day for 7-14 days
For uncomplicated infections of the urinary tract and kidneys - 250 mg once a day for 3 days
For complicated infections of the urinary tract and kidneys - 250 mg 1 time per day for 7-10 days
With bacterial prostatitis - 500 mg 1 time per day for 28 days
With infections of the skin and soft tissues - 250 mg - 500 mg 1 or 2 times a day for 7-14 days
Intraabdominal infections - 250 mg of Levostar 2 times a day or 500 mg 1 time per day - 7-14 days (in combination with antibacterial drugs acting on anaerobic flora).
Tuberculosis - inside of 500 mg 1-2 times a day for up to 3 months.
For patients with impaired renal function (CC <50 ml / min):
Side effects of the
From the digestive system: nausea, vomiting, diarrhea (including blood), digestive disorders, decreased appetite, abdominal pain, pseudomembranous colitis, increased activity of “liver” transaminases, hyperbilirubinemia, hepatitis,.
From the cardiovascular system: lowering blood pressure, vascular collapse, tachycardia, lengthening the QT interval, very rarely - atrial fibrillation.
Metabolism: hypoglycemia (increased appetite, increased sweating, trembling).
On the part of the nervous system: headache, dizziness, weakness, drowsiness, insomnia, tremor, anxiety, paresthesia, fear, hallucinations, confusion, depression, motor disorders, seizures (in predisposed patients).
On the part of the sensory organs: impaired vision, hearing, smell, taste and tactile sensitivity.
From the musculoskeletal system: arthralgia, muscle weakness, myalgia, tendon rupture, tendonitis, rhabdomyolysis.
From the urinary system: hypercreatininemia, interstitial nephritis, acute renal failure.
From the hemopoietic organs: eosinophilia, hemolytic anemia, leukopenia, neutropenia, agranulocytosis, thrombocytopenia, pancytopenia, hemorrhage.
Allergic reactions: itching and hyperemia of the skin, swelling of the skin and mucous membranes, urticaria, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome), bronchospasm, suffocation, anaphylactic shock, allergic pneumonitis, vasculitis.
Other: photosensitization, asthenia, exacerbation of porphyria, persistent fever, development of superinfection.
Drug interaction
There are reports of a marked decrease in the level of convulsive readiness while using quinolones and substances that, in turn, can lower the threshold for convulsive readiness. This applies equally to the simultaneous use of quinolones, theophylline and NSAIDs. The effect is reduced by drugs that inhibit intestinal motility, sucralfate, magnesium- or aluminum-containing antacids, iron and zinc salts (a break between doses of at least 2 hours is necessary).
Taking glucocorticosteroids increases the risk of tendon rupture.
With the simultaneous use of vitamin K antagonists, control of the blood coagulation system is necessary.
Excretion (renal clearance) of levofloxacin is slightly slowed by the action of cimetidine and probenecid due to the possible blocking of tubular secretion of levofloxacin in the kidneys. It should be noted that this interaction has clinical significance, primarily for patients with impaired renal function. Levofloxacin increases the half-life of cyclosporine.
Overdose
The expected symptoms of an overdose of Levofloxacin are manifested at the central nervous system level (confusion, dizziness, impaired consciousness and seizures of the type of epipridesy). In addition, gastrointestinal upsets (such as nausea) and erosive lesions of the mucous membranes may occur. From the cardiovascular system, an extension of the QT interval can be observed.
Symptomatic treatment. ECG monitoring is required to monitor the QT interval. You can use antacids. Levofloxacin is not excreted by dialysis. There is no specific antidote.
dosage form
tablets
Appointment srdllpp sl m in naznacheniyu wizard, Detyam in naznacheniyu Vracha
Indications
Bronchitis, From pneumonia, From respiratory tract infections, From boils, From sinusitis, From skin infections, From inflammation of female genital organs, From tuberculosis, From infectious diseases, From infection
Actavis Ltd, Iceland
Levostar tablets, film-coated in pink, oval, biconvex, with a notch on one side and an engraving L on the other.
Pharmacological action
Levofloxacin is a broad-spectrum antibiotic from the group of fluoroquinolones, containing as active substance levorotatory ofloxacin isomer. It blocks DNA gyrase (topoisomerase II) and topoisomerase IV, disrupts supercoiling and cross-linking of DNA breaks, inhibits DNA synthesis, and causes deep morphological changes in the cytoplasm, cell wall and membranes.
Effective against most strains of microorganisms both in vitro and in vivo. By the action of the drug sensitive:
- Gram positive microorganisms - Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes and Streptococcus agalactiae, Viridans group streptococci
- Gram-negative organisms - Enterobacter cloacae, Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter sakazakii, Escherichiacoli, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Klebsiella oxytoca, Legionella pneumoniae, Moraxella catarrhalis, Proteus mirabilis, Pseudomonas aeruginosa, Pseudomonas fluorescens, Acinetobacter anitratus, Acinetobacter baumannii, Acinetobacter calcoaceticus, Bordetella pertussis, Citrobacter diversus, Citrobacter freundii, Proteus vulgaris, Providencia rettgeri, Providencia stuartii , Serratia marcescens
are also sensitive anaerobic microorganisms (Clostridiumperfringens, Bacteroides fragilis) and other groups of microorganisms - Chlamydia pneumoniae, Mycoplasma pneumoniae, Mycobacterium tuberculosis.
Indications
Infectious and inflammatory diseases caused by microorganisms sensitive to the drug: - lower respiratory tract infections (exacerbation of chronic bronchitis, community-acquired pneumonia)
- infections of the ENT organs (acute sinusitis)
- infections of the urinary tract and kidneys acute pyelonephritis)
- infections of the genital organs (including bacterial prostatitis)
- infections of the skin and soft tissues (suppurating atheromas, abscesses, boils)
- intra-abdominal infections
- tuberculosis (complex erapiya drug-resistant forms).
Contraindications
- epilepsy
- tendon damage with previous treatment with quinolones
- pregnancy
- lactation period
- childhood and adolescence (up to 18 years)
- lactose intolerance, lactose intolerance, lactose intolerance, glucose-galactose malabsorption
- hypersensitivity to levofloxacin or other fluoroquinolones, as well as to excipients of the drug Levostar.
Precautions: old age (due to the high likelihood of a concomitant decrease in renal function), glucose-6-phosphate dehydrogenase deficiency
Special instructions
Levofloxacin should be used at least 2 hours before or 2 hours after taking preparations of salts of iron, zinc, antacids and sucralfate.
During treatment, it is necessary to avoid solar and artificial UV radiation in order to avoid damage to the skin (photosensitivity).
When signs of tendonitis, pseudomembranous colitis appear, Allergic reactions Levofloxacin is immediately canceled.
It should be borne in mind that in patients with a history of brain damage (stroke, severe trauma), seizures may develop, with glucose-6-phosphate dehydrogenase deficiency, there is a risk of hemolysis.
Effect of Levostarf on the ability to drive vehicles and control mechanisms
During treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Composition
1 tablet: - levofloxacin hemihydrate 256.23 mg, respectively. the content of levofloxacin 250 mg
- levofloxacin hemihydrate 512.46 mg, respectively. levofloxacin 500 mg
Excipients: sodium stearyl fumarate, crospovidone (polyplasdone XL), anhydrous silicon dioxide colloidal (Aerosil 200), copovidone (Plasdon S-630), microcrystalline cellulose.
Film composition: Opadry II pink 31K34554 (lactose monohydrate, HPMC 2910 / hypromellose 15cP, titanium dioxide, triacetin, iron oxide red, iron oxide yellow).
Dosage and administration
Inside, during meals or between meals, without chewing, with plenty of fluids.
Doses are determined by the nature and severity of the infection, as well as the sensitivity of the suspected pathogen,
Recommended dose of Levostar for adults with normal renal function (CC> 50 ml / min): In acute sinusitis - 500 mg 1 time per day for 10-14 days
In case of exacerbation of chronic bronchitis - from 250 to 500 mg 1 time per day for 7-10 days
In community-acquired pneumonia - 500 mg of Levostar 1 or 2 times a day for 7-14 days
For uncomplicated infections of the urinary tract and kidneys - 250 mg once a day for 3 days
For complicated infections of the urinary tract and kidneys - 250 mg 1 time per day for 7-10 days
With bacterial prostatitis - 500 mg 1 time per day for 28 days
With infections of the skin and soft tissues - 250 mg - 500 mg 1 or 2 times a day for 7-14 days
Intraabdominal infections - 250 mg of Levostar 2 times a day or 500 mg 1 time per day - 7-14 days (in combination with antibacterial drugs acting on anaerobic flora).
Tuberculosis - inside of 500 mg 1-2 times a day for up to 3 months.
For patients with impaired renal function (CC <50 ml / min):
Side effects of the
From the digestive system: nausea, vomiting, diarrhea (including blood), digestive disorders, decreased appetite, abdominal pain, pseudomembranous colitis, increased activity of “liver” transaminases, hyperbilirubinemia, hepatitis,.
From the cardiovascular system: lowering blood pressure, vascular collapse, tachycardia, lengthening the QT interval, very rarely - atrial fibrillation.
Metabolism: hypoglycemia (increased appetite, increased sweating, trembling).
On the part of the nervous system: headache, dizziness, weakness, drowsiness, insomnia, tremor, anxiety, paresthesia, fear, hallucinations, confusion, depression, motor disorders, seizures (in predisposed patients).
On the part of the sensory organs: impaired vision, hearing, smell, taste and tactile sensitivity.
From the musculoskeletal system: arthralgia, muscle weakness, myalgia, tendon rupture, tendonitis, rhabdomyolysis.
From the urinary system: hypercreatininemia, interstitial nephritis, acute renal failure.
From the hemopoietic organs: eosinophilia, hemolytic anemia, leukopenia, neutropenia, agranulocytosis, thrombocytopenia, pancytopenia, hemorrhage.
Allergic reactions: itching and hyperemia of the skin, swelling of the skin and mucous membranes, urticaria, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome), bronchospasm, suffocation, anaphylactic shock, allergic pneumonitis, vasculitis.
Other: photosensitization, asthenia, exacerbation of porphyria, persistent fever, development of superinfection.
Drug interaction
There are reports of a marked decrease in the level of convulsive readiness while using quinolones and substances that, in turn, can lower the threshold for convulsive readiness. This applies equally to the simultaneous use of quinolones, theophylline and NSAIDs. The effect is reduced by drugs that inhibit intestinal motility, sucralfate, magnesium- or aluminum-containing antacids, iron and zinc salts (a break between doses of at least 2 hours is necessary).
Taking glucocorticosteroids increases the risk of tendon rupture.
With the simultaneous use of vitamin K antagonists, control of the blood coagulation system is necessary.
Excretion (renal clearance) of levofloxacin is slightly slowed by the action of cimetidine and probenecid due to the possible blocking of tubular secretion of levofloxacin in the kidneys. It should be noted that this interaction has clinical significance, primarily for patients with impaired renal function. Levofloxacin increases the half-life of cyclosporine.
Overdose
The expected symptoms of an overdose of Levofloxacin are manifested at the central nervous system level (confusion, dizziness, impaired consciousness and seizures of the type of epipridesy). In addition, gastrointestinal upsets (such as nausea) and erosive lesions of the mucous membranes may occur. From the cardiovascular system, an extension of the QT interval can be observed.
Symptomatic treatment. ECG monitoring is required to monitor the QT interval. You can use antacids. Levofloxacin is not excreted by dialysis. There is no specific antidote.
dosage form
tablets
Appointment srdllpp sl m in naznacheniyu wizard, Detyam in naznacheniyu Vracha
Indications
Bronchitis, From pneumonia, From respiratory tract infections, From boils, From sinusitis, From skin infections, From inflammation of female genital organs, From tuberculosis, From infectious diseases, From infection
Actavis Ltd, Iceland
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