Levofloxacin | Levofloxacin infusion solution 5 mg / ml 100 ml vial 1 pc.
Special Price
$14.55
Regular Price
$22.00
In stock
SKU
BID617509
Release form
Solution for infusion
Solution for infusion
Release form
Solution for infusion
Packing
bottle 100 ml
Pharmacological action
Broad-spectrum antimicrobial agent, fluoroquinolone. It is bactericidal. Blocks DNA gyrase (topoisomerase II) and topoisomerase IV, disrupts the supercoiling and cross-linking of DNA breaks, inhibits DNA synthesis, causes deep morphological changes in the cytoplasm, cell wall and membranes.
active against Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes and Streptococcus agalactiae, Viridans group streptococci, Enterobacter cloacae, Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter sakazakii, Escherichia coli, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Klebsiella oxytoca, Legionella pneumoniae, Moraxella catarrhalis, Proteus mirabilis, Pseudomonas aeruginosa, Pseudomonas fluorescens, Chlamydia pneumoniae, Mycoplasma pneumoniae, Acinetobacter anitratus, Acinetobacter baumannii, Acinetobacter calcoaceticus, Bordetella pertussis, Citrobacter diversus, Citrobacter freundii, Morganella morganii, Proteus vulgaris, Providencia rettgeri , Providcncia stuartii, Serratia marcescens, Clostridium perfringens.
Indications
Therapy for lungs, moderate and severe infections caused by strains of microorganisms sensitive to levofloxacin: acute sinusitis caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarhalis
Special instructions
The infusion solution of the drug is compatible with the following infusion solutions: saline solution, 5% glucose solution, 2.5% Ringer's solution with dextrose, combined solutions for parenteral nutrition (amino acids, carbohydrates, electrolytes). The infusion solution of the drug should not be mixed with heparin or solutions with an alkaline reaction (for example, with sodium bicarbonate solution).
Influence on the ability to drive a car and potentially dangerous mechanisms: during the treatment period, it is necessary to abandon driving and potentially dangerous mechanisms due to the possible appearance of dizziness, drowsiness, stiffness and visual impairment, which can lead to poor reactivity and reduced concentration.
Composition
Active ingredient - levofloxacin hemihydrate (in terms of levofloxacin) - 5 g.
Excipients: sodium chloride - 900 mg, lactic acid - 25 mg, water d / and - up to 100 ml.
Dosage and administration
The drug Levofloxacin is administered intravenously slowly, 250-750 mg every 24 hours (a dose of 250-500 mg is administered for 60 minutes, 750 mg for 90 minutes). A subsequent transition to oral administration in the same dose is possible. The duration of treatment depends on the indications for use, as well as the sensitivity of the alleged pathogen. The recommended dosage regimen should be strictly observed. The use of the drug is recommended to continue for 2-3 days after normalization of body temperature. Independent interruption or premature termination of treatment with the drug is unacceptable.
With pneumonia iv 500 mg 1-2 times / day. within 7-14 days.
In uncomplicated urinary tract infections - iv 250 mg 1 time / day, for 3 days. In severe infections of the urinary tract and kidneys, the dose for iv administration and the duration of treatment can be increased.
For infections of the skin and soft tissues iv - 500 mg 2 times / day. within 7-14 days.
In severe pneumonia caused by pneumococcus and hospital infection caused by the pathogen Pseudomonas aeruginosa, the use of the drug may not be effective enough and may require combined treatment.
Patients with impaired renal function need to adjust the dosage regimen depending on the creatinine clearance, prescribe the drug as follows: When creatinitis clearance is 50-20 ml / min, the usual dose is administered on the first day (recommended for patients with normal creatinine clearance), starting from the second day - the dose is halved.
When creatinitis clearance is 19-10 ml / min, the usual dose is administered on the first day (recommended for patients with normal creatinine clearance), starting from the second day - the drug dose is reduced four times.
When creatinitis clearance is less than 10 ml / min (including hemodialysis and long-term ambulatory peritoneal dialysis), the usual dose is administered on the first day (recommended for patients with normal creatinine clearance). At the prescribed doses of not more than 500 mg / day., Starting from the second day - the dose is reduced four times. Patients who are prescribed a dose of 500 to 1000 mg / day. Starting from the second day, the dose is reduced by eight times.
Side effects
Allergic reactions: sometimes - itching and redness of the skin rarely - anaphylactic and anaphylactoid reactions (manifested by symptoms such as urticaria, facial swelling, very rarely - a sudden drop in blood pressure and shock in some cases - Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome) and exudative multiform erythema
Local reactions: with intravenous administration, pain and inflammation at the injection site, back and chest pain, increased sweating
From the nervous system: sometimes headache, dizziness, fatigue, taste violation sensitivity rarely - paresthesia in the hands, tremors, restlessness, anxiety, seizures, convulsions, and confusion, very rarely - visual and hearing impairment, disturbances of taste and smell sensitivity, reduction of tactile sensitivity, impaired concentration, psychotic reactions such as hallucinations and depression, impaired coordination (including walking)
From the digestive system: often - nausea, diarrhea, sometimes - loss of appetite, vomiting, abdominal pain, digestion rarely - dry mouth, gastrointestinal intestinal bleeding, increased serum bilirubin) is very rare - diarrhea with blood (in very rare cases, this can be a sign of intestinal inflammation or pseudomembranous colitis, impaired liver function (hepatitis, cholelithiasis). irrigation: sometimes - eosinophilia, leukopenia rarely - neutropenia, thrombocytopenia (increased tendency to hemorrhage or bleeding) very rarely - severe agranulocytosis (accompanied by persistent or recurrent fever, inflammation of the tonsils and persistent deterioration of well-being) in some cases - hemolytic anemia, pancytopenia.
On the part of the cardiovascular system: rarely - tachycardia, hypotension and hypertension very rarely - increase in the QT interval on the cardiogram, vascular collapse, flutter-ventricular fibrillation
On the part of the musculoskeletal system: rarely - tendon lesions (including tendonitis), articular and muscle pain is very rare - Achilles tendon rupture (may be bilateral in nature and may occur within 48 hours after the start of treatment), muscle weakness (is especially important for patients with myasthenia gravis) in some cases - rhabdomyolysis.
From the genitourinary system: sometimes - vaginitis, very rarely - impaired renal function up to acute renal failure (for example, due to allergic reactions - interstitial nephritis).
Other sometimes - asthenia is very rare - hypoglycemia, fever, allergic pneumonitis, vasculitis.
Laboratory indicators: sometimes - increased activity of ALT, AST, increased serum creatinine rarely - increased LDH, increased or decreased glucose.
Drug Interactions
With the combined treatment of fenbufen and similar NSAIDs, theophylline may increase the threshold for seizure readiness.
Sucalfalt, iron salts and magnesium or aluminum containing antacids significantly reduce the effect of levofloxacin (the interval between doses should be at least 2 hours).
When used simultaneously with warfarin, prothrombin time and bleeding risk increase (careful monitoring of INR, prothrombin time and other coagulation indicators, as well as monitoring of possible signs of bleeding).
Excretion of levofloxacin slightly slows down under the action of cimetidine and probenecid. Levofloxacin causes a slight increase in T1 / 2 of cyclosporine from blood plasma.
Glucocorticoids increase the risk of tendon rupture (especially in old age).
Alcohol can enhance side effects of the central nervous system (dizziness, numbness, drowsiness)
In patients with diabetes receiving oral hypoglycemic agents or insulin, hypo- and hyperglycemic conditions are possible while taking levofloxacin (careful monitoring of blood glucose levels is recommended).
active substance
Levofloxacin
Conditions of dispatch from
pharmacies Prescription
Prescribed by the doctor, Children as prescribed by the doctor, Children as prescribed by the doctor
Krasfarma, Russia
Solution for infusion
Packing
bottle 100 ml
Pharmacological action
Broad-spectrum antimicrobial agent, fluoroquinolone. It is bactericidal. Blocks DNA gyrase (topoisomerase II) and topoisomerase IV, disrupts the supercoiling and cross-linking of DNA breaks, inhibits DNA synthesis, causes deep morphological changes in the cytoplasm, cell wall and membranes.
active against Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes and Streptococcus agalactiae, Viridans group streptococci, Enterobacter cloacae, Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter sakazakii, Escherichia coli, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Klebsiella oxytoca, Legionella pneumoniae, Moraxella catarrhalis, Proteus mirabilis, Pseudomonas aeruginosa, Pseudomonas fluorescens, Chlamydia pneumoniae, Mycoplasma pneumoniae, Acinetobacter anitratus, Acinetobacter baumannii, Acinetobacter calcoaceticus, Bordetella pertussis, Citrobacter diversus, Citrobacter freundii, Morganella morganii, Proteus vulgaris, Providencia rettgeri , Providcncia stuartii, Serratia marcescens, Clostridium perfringens.
Indications
Therapy for lungs, moderate and severe infections caused by strains of microorganisms sensitive to levofloxacin: acute sinusitis caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarhalis
Special instructions
The infusion solution of the drug is compatible with the following infusion solutions: saline solution, 5% glucose solution, 2.5% Ringer's solution with dextrose, combined solutions for parenteral nutrition (amino acids, carbohydrates, electrolytes). The infusion solution of the drug should not be mixed with heparin or solutions with an alkaline reaction (for example, with sodium bicarbonate solution).
Influence on the ability to drive a car and potentially dangerous mechanisms: during the treatment period, it is necessary to abandon driving and potentially dangerous mechanisms due to the possible appearance of dizziness, drowsiness, stiffness and visual impairment, which can lead to poor reactivity and reduced concentration.
Composition
Active ingredient - levofloxacin hemihydrate (in terms of levofloxacin) - 5 g.
Excipients: sodium chloride - 900 mg, lactic acid - 25 mg, water d / and - up to 100 ml.
Dosage and administration
The drug Levofloxacin is administered intravenously slowly, 250-750 mg every 24 hours (a dose of 250-500 mg is administered for 60 minutes, 750 mg for 90 minutes). A subsequent transition to oral administration in the same dose is possible. The duration of treatment depends on the indications for use, as well as the sensitivity of the alleged pathogen. The recommended dosage regimen should be strictly observed. The use of the drug is recommended to continue for 2-3 days after normalization of body temperature. Independent interruption or premature termination of treatment with the drug is unacceptable.
With pneumonia iv 500 mg 1-2 times / day. within 7-14 days.
In uncomplicated urinary tract infections - iv 250 mg 1 time / day, for 3 days. In severe infections of the urinary tract and kidneys, the dose for iv administration and the duration of treatment can be increased.
For infections of the skin and soft tissues iv - 500 mg 2 times / day. within 7-14 days.
In severe pneumonia caused by pneumococcus and hospital infection caused by the pathogen Pseudomonas aeruginosa, the use of the drug may not be effective enough and may require combined treatment.
Patients with impaired renal function need to adjust the dosage regimen depending on the creatinine clearance, prescribe the drug as follows: When creatinitis clearance is 50-20 ml / min, the usual dose is administered on the first day (recommended for patients with normal creatinine clearance), starting from the second day - the dose is halved.
When creatinitis clearance is 19-10 ml / min, the usual dose is administered on the first day (recommended for patients with normal creatinine clearance), starting from the second day - the drug dose is reduced four times.
When creatinitis clearance is less than 10 ml / min (including hemodialysis and long-term ambulatory peritoneal dialysis), the usual dose is administered on the first day (recommended for patients with normal creatinine clearance). At the prescribed doses of not more than 500 mg / day., Starting from the second day - the dose is reduced four times. Patients who are prescribed a dose of 500 to 1000 mg / day. Starting from the second day, the dose is reduced by eight times.
Side effects
Allergic reactions: sometimes - itching and redness of the skin rarely - anaphylactic and anaphylactoid reactions (manifested by symptoms such as urticaria, facial swelling, very rarely - a sudden drop in blood pressure and shock in some cases - Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome) and exudative multiform erythema
Local reactions: with intravenous administration, pain and inflammation at the injection site, back and chest pain, increased sweating
From the nervous system: sometimes headache, dizziness, fatigue, taste violation sensitivity rarely - paresthesia in the hands, tremors, restlessness, anxiety, seizures, convulsions, and confusion, very rarely - visual and hearing impairment, disturbances of taste and smell sensitivity, reduction of tactile sensitivity, impaired concentration, psychotic reactions such as hallucinations and depression, impaired coordination (including walking)
From the digestive system: often - nausea, diarrhea, sometimes - loss of appetite, vomiting, abdominal pain, digestion rarely - dry mouth, gastrointestinal intestinal bleeding, increased serum bilirubin) is very rare - diarrhea with blood (in very rare cases, this can be a sign of intestinal inflammation or pseudomembranous colitis, impaired liver function (hepatitis, cholelithiasis). irrigation: sometimes - eosinophilia, leukopenia rarely - neutropenia, thrombocytopenia (increased tendency to hemorrhage or bleeding) very rarely - severe agranulocytosis (accompanied by persistent or recurrent fever, inflammation of the tonsils and persistent deterioration of well-being) in some cases - hemolytic anemia, pancytopenia.
On the part of the cardiovascular system: rarely - tachycardia, hypotension and hypertension very rarely - increase in the QT interval on the cardiogram, vascular collapse, flutter-ventricular fibrillation
On the part of the musculoskeletal system: rarely - tendon lesions (including tendonitis), articular and muscle pain is very rare - Achilles tendon rupture (may be bilateral in nature and may occur within 48 hours after the start of treatment), muscle weakness (is especially important for patients with myasthenia gravis) in some cases - rhabdomyolysis.
From the genitourinary system: sometimes - vaginitis, very rarely - impaired renal function up to acute renal failure (for example, due to allergic reactions - interstitial nephritis).
Other sometimes - asthenia is very rare - hypoglycemia, fever, allergic pneumonitis, vasculitis.
Laboratory indicators: sometimes - increased activity of ALT, AST, increased serum creatinine rarely - increased LDH, increased or decreased glucose.
Drug Interactions
With the combined treatment of fenbufen and similar NSAIDs, theophylline may increase the threshold for seizure readiness.
Sucalfalt, iron salts and magnesium or aluminum containing antacids significantly reduce the effect of levofloxacin (the interval between doses should be at least 2 hours).
When used simultaneously with warfarin, prothrombin time and bleeding risk increase (careful monitoring of INR, prothrombin time and other coagulation indicators, as well as monitoring of possible signs of bleeding).
Excretion of levofloxacin slightly slows down under the action of cimetidine and probenecid. Levofloxacin causes a slight increase in T1 / 2 of cyclosporine from blood plasma.
Glucocorticoids increase the risk of tendon rupture (especially in old age).
Alcohol can enhance side effects of the central nervous system (dizziness, numbness, drowsiness)
In patients with diabetes receiving oral hypoglycemic agents or insulin, hypo- and hyperglycemic conditions are possible while taking levofloxacin (careful monitoring of blood glucose levels is recommended).
active substance
Levofloxacin
Conditions of dispatch from
pharmacies Prescription
Prescribed by the doctor, Children as prescribed by the doctor, Children as prescribed by the doctor
Krasfarma, Russia
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