Levofloxacin | Highleflox tablets 500 mg, 5 pcs.

Packing

5 pcs.

Pharmacological action

Haileflox has a broad spectrum antibacterial effect.

Indications

Infectious and inflammatory diseases of mild to moderate severity, caused by drug-sensitive microorganisms: lower respiratory tract infections (pneumonia, exacerbation of chronic bronchitis)

acute bacterial sinusitis

infections of the urinary tract and kidneys (including acute pyelonephritis)

infections of the skin and soft tissues (suppurative atheroma, abscess, spermatic furuncle)

intra-abdominal infection (in combination with antibacterial drugs acting on anaerobic microflora)

tuberculosis (as part of complex treatment of drug-oral stable forms).

Contraindications

hypersensitivity to levofoxacin, other fluoroquinolones or other components of the drug with a history of

epilepsy

tendon damage associated with taking quinolones in the history of

children and adolescents under 18 years of age

pregnancy

lactation.

Precautions - advanced age (high likelihood of a concomitant decrease in renal function), glucose-6-phosphate dehydrogenase deficiency.

Special instructions

After normalization of body temperature, it is recommended to continue treatment for at least 48–72 hours. Levofloxacin is taken at least 2 hours before or 2 hours after taking magnesium / aluminum or sucralfate antacids, or other preparations containing calcium, iron or zinc. Due to possible photosensitization during the treatment period and within 5 days after the end of treatment with levofloxacin, it is necessary to avoid solar and artificial UV radiation. With the development of phototoxicity, drug treatment should be discontinued. When signs of tendonitis and pseudomembranous colitis appear, levofloxacin is immediately canceled. It should be borne in mind that in patients with a history of brain damage (stroke, severe trauma), seizures may develop. With glucose-6-phosphate dehydrogenase deficiency, a risk of hemolytic reactions is possible. In patients with diabetes mellitus during treatment with levofloxacin should carefully monitor the level of glucose in the blood. With the simultaneous use of levofloxacin and warfarin, monitoring of PV, INR or other anticoagulation tests is indicated, as well as monitoring of signs of bleeding. While taking levofloxacin, the patient’s ability to concentrate and the speed of psychomotor reactions may be impaired. In this regard, care must be taken when driving vehicles and engaging in other potentially dangerous activities. After normalizing body temperature, it is recommended to continue treatment for at least 48–72 hours. Levofloxacin is taken at least 2 hours before or 2 hours after taking magnesium antacids / aluminum or sucralfate, or other drugs, containing calcium, iron or zinc. Due to possible photosensitization during the treatment period and within 5 days after the end of treatment with levofloxacin, it is necessary to avoid solar and artificial UV radiation. With the development of phototoxicity, drug treatment should be discontinued. When signs of tendonitis and pseudomembranous colitis appear, levofloxacin is immediately canceled. It should be borne in mind that in patients with a history of brain damage (stroke, severe trauma), seizures may develop. With glucose-6-phosphate dehydrogenase deficiency, a risk of hemolytic reactions is possible. In patients with diabetes mellitus during treatment with levofloxacin should carefully monitor the level of glucose in the blood. With the simultaneous use of levofloxacin and warfarin, monitoring of PV, INR or other anticoagulation tests is indicated, as well as monitoring for signs of bleeding. While taking levofloxacin, the patient’s ability to concentrate and the speed of psychomotor reactions may be impaired. In this regard, care must be taken when driving vehicles and engaging in other potentially hazardous activities.

Composition of

1 tablet contains levofloxacfarafd 1 500 mg of levofloxacacfd dacff70 mg

Dosage and administration of

Hyleflox is taken orally, before meals or in between meals, without chewing, with plenty of water.

In adult patients with normal renal function (creatinine Cl> 50 ml / min), use in accordance with the schemes shown in the table: Hospital pneumonia 750 mg 1 time / day. 7-14 days

Community-acquired pneumonia 500 mg 1ֲ times / day. 7-14 days 750 mg 1 time / day. 5 * days

Exacerbation of chronic bronchitis 500 mg 1 time / day. 7 days

Acute bacterial sinusitis 500 mg 1 time / day. 10-14 days 750 mg 1 time / day. 5 days

Uncomplicated urinary tract infections 250 mg 1 time / day. 3 days

Complicated urinary tract infections, including acute pyelonephritis 250 mg 1 time / day. 10 ** days 750 mg 1 time / day. 5 *** days

Uncomplicated infections of the skin and subcutaneous tissue 500 mg 1 time / day. 7-10 days

Complicated infections of the skin and subcutaneous tissues 750 mg 1 time / day. 7-14 days

Chronic bacterial prostatitis 500 mg 1 time / day. 28 days

Intraabdominal infection (in combination with antibacterial drugs acting on anaerobic microflora) 500 mg 1 time / day. 7-14 days

Tuberculosis (as part of complex therapy of drug-resistant forms) 750 mg 1 time / day. up to 3 months

* This regimen is indicated for the treatment of community-acquired pneumonia caused by Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, Mycoplasma pneumoniae, Chlamydia pneumoniae.

** This regimen is indicated for the treatment of urinary tract infections caused by Enterococcus faecalis, Enterococcus cloacae, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and acute pyelonephritis caused by Escherichia coli.

*** This regimen is indicated for the treatment of urinary tract infections caused by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, and acute pyelonephritis caused by Escherichia coli, including cases with concomitant bacteremia.

Side effects

From the nervous system: headache, dizziness, weakness, drowsiness, insomnia, tremor, anxiety, paresthesia, fear, hallucinations, confusion, depression, motor disorders, convulsions.

On the part of the sensory organs: impaired vision, hearing, smell, taste and tactile sensitivity.

From the CCC side: decreased blood pressure, vascular collapse, tachycardia, lengthening of the QT interval, atrial fibrillation.

From the digestive system: nausea, vomiting, diarrhea (including blood), digestive disorders, decreased appetite, abdominal pain, pseudomembranous colitis, increased activity of hepatic transaminases, hyperbilirubinemia, hepatitis, dysbiosis.

From the side of metabolism: hypoglycemia (increased appetite, increased sweating, trembling, nervousness).

From the musculoskeletal system: arthralgia, muscle weakness, myalgia, rhabdomyolysis, tendon rupture, tendonitis.

From the urinary system: hypercreatininemia, interstitial nephritis, acute renal failure.

From the hemopoietic organs: eosinophilia, hemolytic anemia, leukopenia, neutropenia, agranulocytosis, thrombocytopenia, pancytopenia, hemorrhage.

Allergic reactions: itching and hyperemia of the skin, swelling of the skin and mucous membranes, urticaria, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome), bronchospasm, suffocation, anaphylactic shock, allergic pneumonitis.

Other: photosensitization, asthenia, exacerbation of porphyria, persistent fever, development of superinfection.

Drug Interactions

Levofloxacin increases the half-life of cyclosporine. The effect of levofloxacin is reduced by drugs that inhibit intestinal motility, sucralfate, aluminum or magnesium-containing antacid drugs and iron preparations. NSAIDs and theophylline when used simultaneously with levofloxacin increase the risk of seizures in predisposed patients, and corticosteroids increase the risk of tendon rupture. With the simultaneous administration of levofloxacin with hypoglycemic drugs, changes in blood glucose levels are possible, including hyperglycemia and hypoglycemia. Levofloxacin enhances the effect of warfarin. Cimetidine and drugs blocking tubular secretion slow down the excretion of levofloxacin.

Storage Conditions

In a dry, dark place at 8–25 РC.

Deystvuyuschee substances

Levofloxacin

Prescription terms from

pharmacies Prescription

Form of Treatment

tablets

Highlig Laboratories Pvt. Co., Ltd.