Lafrax (Ofloxacin) eye and ear drops 0.3%, 5ml

Bacterial infections of the anterior segment of the eye caused by microorganisms sensitive to ofloxacin in adults and children aged 1 year and older:

• corneal ulcers, conjunctivitis, keratitis, keratoconjunctivitis, blepharitis, blepharoconjunctivitis, dacryocystitis, meibomitis (barley), chlamydial eye infections;

• prevention and treatment of bacterial infection after eye injuries and surgical interventions.

Infectious diseases of the eyes.
The drug is instilled in 1 drop into the conjunctival sac of the diseased eye 2-4 times a day. It is not recommended to use the drug for more than 2 weeks.

Ear infections
Adults and children over 12 years of age
The frequency of use of the drug and the duration of treatment are determined by the doctor individually.
As a rule, in case of otitis externa, 10 drops are instilled into the affected ear 2 times a day for 10 days.
In the treatment of chronic suppurative otitis media with chronic perforation of the tympanic membrane, the recommended dose is 10 drops into the affected ear 2 times a day for 14 days.

Children from 1 to 11 years
The frequency of drug use and the duration of treatment are established by the doctor individually.
For the treatment of otitis externa and acute otitis media with an installed tympanostomy tube, the recommended dose is 5 drops into the affected ear 2 times a day for 10 days.

Before instillation, you should warm the bottle in your hand for 1-2 minutes to avoid the development of dizziness (possibly when using a cold solution). Instillation is performed with the patient lying on his side. After instillation, the patient should maintain this position for 5 minutes to facilitate the passage of the solution through the external auditory canal. If necessary, instillation into the other ear acts in a similar way.

Eye and ear drops in the form of a clear solution of light yellow or greenish-yellow color.

1 ml

ofloxacin 3 mg

Excipients: sodium dihydrogen phosphate dihydrate - 13.22 mg, sodium hydrogen phosphate dihydrate - 8.01 mg, benzalkonium chloride - 0.05 mg, water d / i - up to 1 ml.

• Hypersensitivity to drug components and other quinolone derivatives;

• non-bacterial diseases of the accessory apparatus of the eye, anterior and posterior segment of the eye;

• non-bacterial otitis media;

• children's age (up to 1 year);

• pregnancy, breastfeeding period.

pharmachologic effect

A broad-spectrum antimicrobial drug from the group of fluoroquinolones, acts on the bacterial enzyme DNA gyrase, which ensures supercoiling and, thus, the stability of DNA bacteria (destabilization of DNA strands leads to their death). Has a bactericidal effect. It is active against microorganisms producing ?-lactamases and fast-growing atypical mycobacteria. Susceptible to the drug: Staphylococcus aureus (including strains), Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus faecalis, Corynebacterium spp., Micrococcus spp., Bacillus spp., Enterobacteria spp., Enterobacteri spp., Enterobacteria spp. Proteus spp., Salmonella spp., Serratia spp., Shigella spp.), Pseudomonas aeruginosa and Pseudomonas species, Haemophilus influenzae, Haemophilus ducreyi,Branhamella catarrhalis, Neisseria gonorrhoeae, Neisseria meningitidis, Acinetobacter spp., Campylobacter spp., Gardnerella vaginalis, Helicobacter pylori, Brucella spp.

The drug is also active against Chlamydia trachomatis, Chlamydia pneumoniae, Mycoplasma pneumoniae and some other mycoplasmas. Clostridium species, Bacteroides species and Peptococcus species are resistant.

The resistance of Pseudomonas aeruginosa ranges between 15-20% and the resistance of Staphylococcus aureus between 5-10%.

Side effect

After introduction into the conjunctival sac, the following are possible: transient burning sensation or discomfort in the eye, conjunctival hyperemia, blurred vision, pain in the eye, itching sensation. When applied in the form of ear drops, it is possible: the appearance of itching and a bitter taste in the mouth; extremely rare - eczema, paresthesia, dizziness, ear pain, ringing in the ears, dry mouth.

Application during pregnancy and lactation

Use during pregnancy and breastfeeding is contraindicated.

special instructions

As with other antimicrobial drugs, long-term use of ofloxacin can lead to the growth of flora insensitive to it. Therefore, in the absence of clinical improvement during the standard treatment period or worsening of the condition, it is necessary to discontinue the drug and begin alternative therapy. Contact lenses should be removed before instilling the drug and reinstalled 20 minutes after instillation. The drug should not be injected subconjunctivally or into the anterior chamber of the eye. Influence on the ability to drive vehicles and mechanisms Patients who, after using the drug in the eyes, have a short-term impairment of the clarity of visual perception, should not drive vehicles and mechanisms within 15 minutes after using the drug.

Overdose

There are no data on systemic manifestations of overdose. After topical application of an excessive dose of the drug, the eyes should be rinsed with clean water at room temperature.

Drug interactions

Magnesium, aluminum, iron and zinc reduce the absorption of ofloxacin.