Kudesan Drops for oral administration, 3%, 20 ml

general description

Cardiotonic drugs

Special conditions

Influence on the ability to drive vehicles and mechanisms:

No data.

Drug interactions

The simultaneous use of lipid-lowering agents (statins, fibrates), beta-blockers (atenolol, metoprolol, propranolol), tricyclic antidepressants can lead to a decrease in the concentration of ubidecarenone in the blood plasma.

Ubidecarenone may reduce the effects of warfarin.

Ubidecarenone can potentiate the action of diltiazem, metoprolol, enalapril and nitrates.

Pharmacodynamics

Ubidecarenone (coenzyme Q10, ubiquinone) is a natural substance that is a vitamin-like coenzyme. Ubidecarenone is an endogenous substrate that takes part in the transfer of electrons in the transport chain of redox processes, in the process of energy exchange, in the reaction of oxidative phosphorylation in the respiratory chain of cell mitochondria. Participates in the processes of cellular respiration, increasing the synthesis of adenosine triphosphoric acid (ATP). Provides clinically significant antioxidant effects. Protects cell membrane lipids from peroxidation. Reduces the zone of myocardial damage in conditions of ischemia and reperfusion. Ubidecarenone prevents lengthening of the QT interval, improves exercise tolerance.Due to endogenous synthesis, 100% of the body's need for coenzyme Q10 is satisfied only until the age of 20. The concentration of coenzyme Q10 decreases in elderly patients, as well as in various diseases in both adults and children.

Indications

- As part of complex therapy:

In adults: chronic heart failure, dilated cardiomyopathy, ischemic heart disease, including myocardial infarction (during the period of rehabilitation therapy), arrhythmias, arterial hypertension.

In children from 1 year of age: chronic heart failure, dilated cardiomyopathy, arrhythmias, chronic gastroduodenitis, chronic pyelonephritis, metabolic nephropathy, migraine, neuro-circulatory dystonia, hereditary neurodegenerative diseases (mitochondrial encephalomyopathy (MELAS syndrome), Leiger's syndrome, tuberosis) myopathies, muscular dystrophies, diseases associated with metabolic disorders (asthenic syndrome, the recovery period after severe diseases and surgical interventions).

- The period of preparation for heart surgery (coronary artery bypass grafting, congenital and acquired defects) in adults and children from 1 year on the recommendation of a doctor.

- To improve adaptation to increased physical activity in adults and children from 1 year old.

- For the prevention and replenishment of coenzyme Q10 deficiency in adults and children from 1 year old.

Contraindications

Hypersensitivity to drug components.

Children up to age 1 year.

Carefully:

With arterial hypotension.

Pregnancy and lactation:

The drug is not recommended for pregnant and lactating women due to the lack of sufficient clinical experience.

Overdose

No data.

Side effects

Allergic reactions are possible.

Very rare: nausea, diarrhea

INN / Active ingredient

Ubidecarenone

Dosage

30mg / ml x 20ml

Structure

1 ml of the drug contains:

Active ingredient: ubidecarenone - 30 mg.

Excipients: alpha-tocopherol acetate 4.5 mg, ascorbyl palmitate 1.0 mg, macrogol glyceryl hydroxystearate (Cremophor RH-40) 105.0 mg, sodium benzoate 2.0 mg, citric acid (food grade) 1.6 mg, water purified to 1 ml.

Specifications

Release form

Solution

Manufacturer country

Russia

Type of dietary supplement

Coenzyme Q10

Package quantity, pcs

one

Volume, ml.

20 ml

Scope of application

Cardiology

Vacation conditions

Without recipe

A type

Dietary supplement

Package weight, g

60

Mode of application

:

Kudesan is taken at 30 mg (10 drops) per day < br> < br> The recommended duration and frequency of Q10 use is 2 months, 2 times a year.