Korneregel eye gel 5%, 10g

• Treatment of non-inflammatory keratopathy, for example, such as corneal degeneration, recurrent erosions, corneal lesions when wearing contact lenses;

• as an auxiliary therapy to stimulate the healing process of the cornea and conjunctiva during their injuries and burns (chemical and thermal);

• as an adjuvant in the treatment of infectious lesions of the cornea of ??bacterial, viral or fungal origin.

Apply topically. In the lower conjunctival sac of the affected eye, 1 drop is instilled 4 times / day, as well as 1 drop at bedtime.

Eye gel transparent or slightly opalescent, colorless, easily flowing.

1 g

dexpanthenol 50 mg

Excipients: cetrimide - 0.1 mg, disodium edetate - 0.1 mg, carbomer - 0.1 mg, sodium hydroxide - 1.01 mg, water d / i - 945.79 mg.

Individual hypersensitivity to any component of the drug.

The drug is used with caution during pregnancy and during breastfeeding (there are no clinical data).

pharmachologic effect

The active ingredient of the drug Korneregel is dexpanthenol / panthenol, a precursor of pantothenic acid, which, therefore, has all the same biological properties as D-pantothenic acid, which, having converted into coenzyme A in the human body, is involved in many metabolic processes. The data obtained in experiments on animals indicate an increase in fibroblast proliferation and the presence of a regenerating effect. When applied externally, dexpanthenol is able to compensate for the increased need for pantothenic acid in damaged skin or mucous membranes. The eye gel has a high viscosity, which allows for long-term contact of dexpanthenol with the surface of the mucous membrane of the eye.

Pharmacokinetics

According to the results of a study of tritiated dexpanthenol, its absorption through the skin was established. To increase the duration of contact of an aqueous solution of dexpanthenol with the corneal epithelium, Korneregel contains carbomer, which, due to its high molecular weight, does not penetrate into the tissues of the eyeball and is not absorbed into the systemic circulation.

Side effect

Local reactions: itching, hyperemia, conjunctival edema, pain, foreign body sensation, increased tearing, transient blurred vision. Allergic reactions: very rarely - hypersensitivity (itching, skin rashes).

Application during pregnancy and lactation

There are no data on the effects of oral pantothenic acid on pregnancy and fetal development or newborn health. However, it is known that when taken orally, pantothenic acid, into which dexpanthenol is metabolized, freely penetrates the placental barrier and is excreted in breast milk in proportion to the amount of the drug taken. Since there are no data on the concentration of dexpanthenol (pantothenic acid) in blood plasma after topical application in the form of an eye gel, the use of the drug Korneregel during pregnancy and / or during breastfeeding is possible only after consulting a doctor, when the expected benefit to the mother outweighs the potential risk to the fetus and / or a child.

special instructions

Korneregel should not be used as monotherapy for infectious corneal lesions of bacterial, viral or fungal origin. The preservative cetrimide, which is part of the drug, with prolonged or too frequent use, can cause local eye irritation, allergic reactions (burning, redness, sensation of a foreign body in the eye) and damage to the corneal epithelium. During the period of treatment with the drug Korneregel, it is not recommended to wear contact lenses due to the possible incompatibility of the drug with the lens material. However, if contact lenses are still indicated, they should be removed and reinstalled before using the drug Korneregel no earlier than 15 minutes after the instillation of the drug. Do not touch the pipette tip of the tube to the eye. The tube must be closed after each use.If there is no improvement in the condition, signs of eye irritation appear, the patient should stop using the drug and seek medical advice. Influence on the ability to drive vehicles and control mechanisms After instillation of the drug, a thin film forms on the cornea, which can cause short-term blurred vision, thereby reducing the reaction rate. Therefore, you should start driving vehicles and mechanisms when the clarity of vision is restored.thereby reducing the reaction rate. Therefore, you should start driving vehicles and mechanisms when the clarity of vision is restored.thereby reducing the reaction rate. Therefore, you should start driving vehicles and mechanisms when the clarity of vision is restored.

Overdose

There are no data on drug overdose.

Drug interactions

Cases of incompatibility with other drugs are unknown. In cases where additional local therapy with eye drops / ointments is carried out, the interval between the administration of the drug Korneregel and other ophthalmic drugs should be at least 15 minutes. Due to its physical properties, the drug Korneregel can extend the residence time of other ophthalmic drugs on the surface of the mucous membrane of the eye and thereby enhance their effect. Therefore, Korneregel should be applied last.