Korfetsin-SOLOpharm drops 0.5%, 5ml

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BIDL3181885
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Expiration Date: 11/2025

Russian Pharmacy name:

Корфецин-СОЛОфарм капли 0,5%, 5мл

Korfetsin-SOLOpharm drops 0.5%, 5ml; 'For topical application: treatment of infections of the anterior part of the eye caused by microorganisms sensitive to levofloxacin.

Adults and children over 1 year old are instilled 1-2 drops into the affected eye (s) every 2 hours up to 8 times / day during wakefulness during the first 2 days, then 4 times / day from the 3rd to the 7th day. The duration of use is 5-7 days.

Eye drops in the form of a clear solution of yellow or yellowish-green color.

1 ml

levofloxacin (as hemihydrate) 5mg

Epilepsy, tendon damage during previous treatment with quinolones, pregnancy, lactation, childhood and adolescence under 18 years of age, hypersensitivity to levofloxacin.

pharmachologic effect

Broad-spectrum antimicrobial agent, fluoroquinolone. It has a bactericidal effect. Blocks DNA gyrase (topoisomerase II) and topoisomerase IV, disrupts supercoiling and stitching of DNA breaks, inhibits DNA synthesis, and causes deep morphological changes in the cytoplasm, cell wall and membranes.

It is active against Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes and Streptococcus agalactiae, Viridans group streptococci, Enterobacter cloacae, Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter sakazakii, Escherichia coli, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Klebsiella oxytoca, Legionella pneumoniae, Moraxella catarrhalis, Proteus mirabilis, Proteus mirabilis, Pseudomonas aeruginosa, Pseudomonas fluorescens, Chlamydia pneumoniae, Mycoplasma pneumoniae, Acinetobacter anitratus, Acinetobacter baumannii, Acinetobacter calcocella vulgaretus, Provugaris Providcncia stuartii, Serratia marcescens, Clostridium perfringens.

Application during pregnancy and lactation

Levofloxacin is contraindicated during pregnancy and lactation (breastfeeding).

Side effects

The incidence of adverse reactions during therapy with levofloxacin was about 10%. Most often, the severity of adverse reactions ranged from mild to moderate severity; undesirable reactions were noted mainly on the part of the organ of vision. Information on adverse events was obtained in the course of clinical trials and post-registration use. Immune system disorders: rarely (more than 1/10000, but less than 1/1000) - systemic allergic reactions, including skin rash; very rarely (less than 1/10000) - anaphylactic shock. Nervous system disorders: infrequently (more than 1/1000, but less than 1/100) - headache. Violations of the organ of vision: often (more than 1/100, but less than 1/10) - burning in the eye, decreased vision, filamentous mucous discharge in the conjunctival cavity; infrequently (more than 1/1000,but less than 1/100) - chemosis, conjunctival injection, papillary conjunctivitis, eyelid edema, eyelid erythema, eye discomfort, itching in the eye, eye pain, dry eye syndrome, photophobia. Respiratory, chest and mediastinal disorders: infrequently (more than 1/1000, but less than 1/100) - rhinitis; very rarely (less than 1/10000) - laryngeal edema. The profile of adverse events when using the drug in the pediatric population is comparable to the adult population. If any of the side effects indicated in the instructions are aggravated, or you notice any other side effects that are not indicated in the instructions, inform your doctor.chest and mediastinum: infrequently (more than 1/1000, but less than 1/100) - rhinitis; very rarely (less than 1/10000) - laryngeal edema. The profile of adverse events when using the drug in the pediatric population is comparable to the adult population. If any of the side effects indicated in the instructions are aggravated, or you notice any other side effects that are not indicated in the instructions, inform your doctor.chest and mediastinum: infrequently (more than 1/1000, but less than 1/100) - rhinitis; very rarely (less than 1/10000) - laryngeal edema. The profile of adverse events when using the drug in the pediatric population is comparable to the adult population. If any of the side effects indicated in the instructions are aggravated, or you notice any other side effects that are not indicated in the instructions, inform your doctor.

Interaction

Levofloxacin increases the T1 / 2 of cyclosporin. The effect of levofloxacin is reduced by drugs that inhibit intestinal motility, sucralfate, magnesium- and aluminum-containing antacids and iron salts (a break between doses of at least 2 hours is required). With the simultaneous use of NSAIDs, theophylline increases convulsive readiness, GCS - increase the risk of tendon rupture. Cimetidine and drugs blocking tubular secretion slow down the excretion of levofloxacin. Overdose

The total amount of levofloxacin contained in one dropper tube or dropper bottle is too small to cause toxic reactions even after accidental ingestion. After topical application of an excessive dose of the drug, the eyes should be rinsed with clean (tap) water at room temperature.

Special instructions

The drug should not be administered subconjunctivally and into the anterior chamber of the eye. The drug should not be used while wearing hydrophilic (soft) contact lenses due to the presence of benzalkonium chloride preservative in it, which can be absorbed by contact lenses and have an adverse effect on the tissues of the eye, as well as cause discoloration of contact lenses. To avoid contamination of the dropper tip and solution, do not touch the eyelids and tissues around the eye during instillation. With long-term treatment with levofloxacin (as with other antibiotics), excessive growth of insensitive microorganisms, including fungal flora, is possible. If the course of the disease worsens or there is no improvement with the use of levofloxacin, it is necessary to discontinue therapy with levofloxacin and switch to therapy with antibacterial drugs of other groups,with an extended ophthalmological examination, including biomicroscopy and fluorescein test. There are no data on the efficacy and safety of levofloxacin in the treatment of corneal ulcers. In the course of clinical studies, the formation of corneal precipitates was not observed. Influence on the ability to drive vehicles, mechanisms: the drug does not significantly affect the ability to drive vehicles, mechanisms. Immediately after instillation, temporary blurred vision is possible. It is not recommended to drive vehicles and engage in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions until the clarity of visual perception is restoredincluding biomicroscopy and fluorescein test. There are no data on the efficacy and safety of levofloxacin in the treatment of corneal ulcers. In the course of clinical studies, the formation of corneal precipitates was not observed. Influence on the ability to drive vehicles, mechanisms: the drug does not significantly affect the ability to drive vehicles, mechanisms. Immediately after instillation, temporary blurred vision is possible. It is not recommended to drive vehicles and engage in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions until the clarity of visual perception is restoredincluding biomicroscopy and fluorescein test. There are no data on the efficacy and safety of levofloxacin in the treatment of corneal ulcers. In the course of clinical studies, the formation of corneal precipitates was not observed. Influence on the ability to drive vehicles, mechanisms: the drug does not significantly affect the ability to drive vehicles, mechanisms. Immediately after instillation, temporary blurred vision is possible. It is not recommended to drive vehicles and engage in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions, until the clarity of visual perception is restoredThere are no data on the efficacy and safety of levofloxacin in the treatment of corneal ulcers. In the course of clinical studies, the formation of corneal precipitates was not observed. Influence on the ability to drive vehicles, mechanisms: the drug does not significantly affect the ability to drive vehicles, mechanisms. Immediately after instillation, temporary blurred vision is possible. It is not recommended to drive vehicles and engage in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions until the clarity of visual perception is restoredThere are no data on the efficacy and safety of levofloxacin in the treatment of corneal ulcers. In the course of clinical studies, the formation of corneal precipitates was not observed. Influence on the ability to drive vehicles, mechanisms: the drug does not significantly affect the ability to drive vehicles, mechanisms. Immediately after instillation, temporary blurred vision is possible. It is not recommended to drive vehicles and engage in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions, until the clarity of visual perception is restoredthe drug does not significantly affect the ability to drive vehicles, mechanisms. Immediately after instillation, temporary blurred vision is possible. It is not recommended to drive vehicles and engage in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions until the clarity of visual perception is restoredthe drug does not significantly affect the ability to drive vehicles, mechanisms. Immediately after instillation, temporary blurred vision is possible. It is not recommended to drive vehicles and engage in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions until the clarity of visual perception is restored

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