Klenzit-C gel 15g

Special Price $32.34 Regular Price $40.00
In stock
SKU
OTC102038338
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Category

Acne

Scope of the drug

General

Release form

Gel

Manufacturer country

India

Package quantity, pcs

one

Description

Release form, composition and packaging

Gel for external use, white, homogeneous.

1 g

adapalene (micronized) 1 mg

clindamycin phosphate equivalent to clindamycin 10 mg

disodium edetate - 0.5 mg, carbomer 940 (carbopol 940) - 5.5 mg, propylene glycol - 80 mg, methyl parahydroxybenzoate - 1 mg, phenoxyethanol - 2.5 mg, poloxamer 407 - 1 mg, sodium hydroxide - 0.78 mg, purified water - up to 1 g.

15 g - tubes made of laminated foil (1) - cardboard packs.

30 g - tubes made of laminated foil (1) - cardboard packs.

pharmachologic effect

Combined drug for the treatment of acne for external use, the active ingredients of which are adapalene and clindamycin.

Adapalene is a retinoid metabolite that has anti-inflammatory and pronounced comedolytic activity (affects open and closed comedones), normalizes the processes of keratinization and epidermal differentiation. The mechanism of action of the drug is based on the binding of adapalene to specific nuclear receptors of retinoic acid. Adapalen normalizes the process of differentiation of follicular epithelial cells, thus reducing the formation of microcamedones. Suppresses chemotaxis and chemokinetic reactions of polynuclear cells in humans, and also inhibits the metabolism of arachidonic acid and the formation of inflammatory mediators. Thus, we can say that under the influence of adapalene, the cell-mediated inflammatory component of acne is reduced.

Clindamycin is a bacteriostatic antibiotic from the group of lincosamides, has a broad spectrum of action, binds to the 50S subunit of the ribosomal membrane and inhibits protein synthesis in the microbial cell.

Clindamycin phosphate, after application to the skin, is rapidly hydrolyzed by phosphatases in the ducts of the sebaceous glands to form clindamycin, which has antibacterial activity.

The sensitivity of all investigated Propionibacterium acnes strains to clindamycin in vitro (MIC 0.4 μg / ml) was shown.

Pharmacokinetics

The absorption of adapalene through the skin is very low (about 4% of the applied dose).

Excretion from the body occurs mainly with bile.

After external application of clindamycin phosphate, very low concentrations of clindamycin are determined in serum and urine.

Indications for use

- acne.

Before use, you should consult your doctor.

Contraindications for use

Hypersensitivity to the components of the drug, pregnancy, lactation, age up to 12 years (data on safety and efficacy are not available).

With the simultaneous systemic (oral, i / v, i / m) use of clindamycin: Crohn's disease, ulcerative colitis, pseudomembranous colitis (including in history).

The drug should be used with caution for dermatitis, eczema, allergic diseases, the simultaneous use of muscle relaxants.

Dosage regimen

Outwardly.

Before using the Klenzit-S gel, it is necessary to cleanse and dry the skin.

With a light touch, evenly apply the gel to the affected skin once a day before going to bed, avoiding the drug getting into the eyes and lips.

The therapeutic effect develops in 1-4 weeks.

The course of therapy is 2-4 weeks.

Persistent improvement occurs after 3 months of treatment.

Repeated courses of treatment - after consulting a doctor.

Use the drug only according to the route of administration and in the doses indicated in the instructions for use.

With excessive application of the gel, the positive effect does not come faster.

Overdose

Adapalene overdose is unlikely.

When applied externally, clindamycin can be absorbed in amounts causing systemic effects.

In case of overdose, symptomatic and supportive therapy is indicated.

In case of accidental ingestion of the drug, it is necessary to rinse the stomach and immediately consult a doctor.

Side

Name ENG

CLENZIT-C

Clinical and pharmacological group

A drug with antibacterial and comedolytic action for the treatment of acne

ATX code

Other combination preparations for the treatment of acne for external use

Dosage

1mg / g + 10mg / g x 15g

Structure

adapalen

Indications

Acne.

INN / Active ingredient

adapalene, clindamycin (as phosphate)

Contraindications

pregnancy

lactation period (breastfeeding)

hypersensitivity to drug components.

The drug should be used with caution for dermatitis, eczema.

Storage conditions and periods

In a dark place at a temperature of 2-25 degrees.

Expiration date: 2 years

Specifications

Category

Acne

Scope of the drug

General

Release form

Gel

Manufacturer country

India

Package quantity, pcs

one

Scope of application

Dermatology

Way of introduction

Outwardly

Vacation conditions

Without recipe

Brand name

Glenmark Pharma

,

Glenmark

The amount of the dosage form in the primary package

15 g

Primary packaging type

Laminated aluminum tube

Type of consumer packaging

Pack of cardboard

Pharmaco-therapeutic group

Acne rash treatment

Dosage form

Gel for external use

Item weight, g

15

Expiration date in days

730

Package weight, g

2

Mode of application

:

Outwardly.

Before using the Klenzit-S gel, it is necessary to cleanse and dry the skin.

With a light touch, evenly apply the gel to the affected skin once a day before going to bed, avoiding the drug getting into the eyes and lips.

The therapeutic effect develops in 1-4 weeks.

The course of therapy is 2-4 weeks.

Persistent improvement occurs after 3 months of treatment.

Repeated courses of treatment - after consulting a doctor.

Use the drug only according to the route of administration and in the doses indicated in the instructions for use.

With excessive application of the gel, the positive effect does not come faster.

Anatomical and therapeutic characteristics

:

D10AX30 Other combined topical acne preparations

Dosage (volume) of the substance in the preparation

:

In 1 g: < br> adapalene (micronized) 1 mg < br> clindamycin phosphate, equivalent to clindamycin 10 mg

Information on technical characteristics, delivery set, country of manufacture

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