Ketosteril tablets p / o, No. 100
Expiration Date: 05/2027
Russian Pharmacy name:
Кетостерил таблетки п/о, №100
Adults and children aged 3 years and older are prescribed 1 tablet / 5 kg of body weight / day or 100 mg / kg of body weight / day. For adults weighing 70 kg, the dose is usually 4-8 tablets. 3 times / day
The drug is administered orally, as a rule, 3 times / day with meals. The tablets should be swallowed without chewing.
KetosterilЃ is used during the entire period when the glomerular filtration rate is less than 25 ml / min.
In the pre-dialysis period, it is recommended that the protein content in food is not more than 40 g / day, depending on the degree of chronic renal failure.
In patients on dialysis, protein intake should be in accordance with accepted recommendations.
The recommended protein content in food for children 3-10 years old is 1.4-0.8 g / kg / day, for children over 10 years old - 1-0.6 g / kg / day.
Tablets, film-coated yellow, oblong, biconvex.
1 tab.
isoleucine alpha-ketoanalogue (DL-methyl-oxo-2-calcium valerinate) 67 mg
leucine alpha-ketoanalogue (methyl-4-oxo-2-calcium valerinate) 101 mg
phenylalanine alpha-ketoanalogue (oxo-2-phenyl-3-calcium propionate) 68 mg
valine alpha-ketoanalogue (methyl-oxo-2-calcium butyrate) 86 mg
methionine alpha-hydroxyanalogue (DL-hydroxy-2-calcium methylbutyrate) 59 mg
L-lysine monoacetate 105 mg
L-threonine 53 mg
L-tryptophan 23 mg
L-histidine 38 mg
L-tyrosine 30 mg
Excipients: corn starch - 44 mg, povidone - 6 mg, talc - 19.57 mg, colloidal silicon dioxide - 4.4 mg, magnesium stearate - 15 mg, macrogol 6000 - 12.8 mg, soluble povidone - 43.2 mg.
hypercalcemia;
violation of amino acid metabolism;
hypersensitivity to the components of the drug.
In case of hereditary phenylketonuria, it should be borne in mind that the drug contains phenylalanine.
pharmachologic effect
Combined drug. Provides a complete supply of essential amino acids with minimal nitrogen input. Ketone analogs of amino acids in the body are enzymatically transaminated into the corresponding L-amino acids, while breaking down urea. The drug promotes the utilization of nitrogen-containing metabolic products, anabolism of proteins, while reducing the concentration of urea in the serum. Improves nitrogen metabolism. Reduces the concentration of potassium, magnesium and phosphate ions in the blood.
With the systematic use of the drug, an improvement in the condition of patients with chronic renal failure was noted. In some cases, it is possible to delay the initiation of dialysis.
Side effect
From the side of metabolism: in some cases, hypercalcemia may develop.
Application during pregnancy and lactation
Clinical experience with the use of Ketosteril during pregnancy and lactation is insufficient.
Application for impaired renal function
Mainly for patients with a glomerular filtration rate of less than 25 ml / min (however, use at a glomerular filtration rate of more than 25 ml / min is not excluded).
Application in children
It can be used according to indications and in doses that take into account the age of the patients.
special instructions
In case of hypercalcemia, it is recommended to reduce the dose of vitamin D taken. If hypercalcemia persists, then the dose of KetosterilЃ, as well as other sources of calcium, should be reduced.
It is necessary to regularly monitor the calcium content and monitor the decrease in serum phosphate levels.
KetosterilЃ should be taken with food to improve its absorption and conversion to the corresponding amino acids.
It is required to provide sufficient caloric content of food.
In patients with hypersensitivity to the components of the drug, in some cases, allergic reactions may occur.
Overdose
Data on overdose of the drug KetosterilЃ are not provided.
Drug interactions
With the simultaneous administration of drugs containing calcium, an increase in the level of calcium in the blood serum is possible.
As uremic symptoms decrease under the influence of KetosterilЃ, the dose of simultaneously used aluminum hydroxide should be reduced accordingly.
A decrease in serum phosphate levels should be monitored.
In order not to disrupt absorption in the intestine, drugs that form difficultly soluble compounds with calcium (for example, tetracyclines, quinolones, preparations containing iron, fluorine and estramustine) should not be taken simultaneously with KetosterilЃ. There should be an interval of at least 2 hours between taking KetosterilЃ and similar drugs.