Ketoprofen | Ketoprofen ampoules 0.05 / ml, 2 ml, 10 pcs.
Special Price
$15.52
Regular Price
$24.00
In stock
SKU
BID472113
Release form
Intramuscular solution.
Intramuscular solution.
Release form
Intramuscular solution.
Packing
10 pcs.
Pharmacological action
Ketoprofen - NSAIDs, has anti-inflammatory, analgesic and antipyretic effects associated with the suppression of the activity of COX1 and COX2 that regulate the synthesis of Pg. Anti-inflammatory effect occurs at the end of 1 week of admission. Ketoprofen lysine salt has an equally pronounced anti-inflammatory, analgesic, antipyretic effect. It has no catabolic effect on articular cartilage.
Contraindications
Hypersensitivity (including to other NSAIDs), aspirin asthma, gastric and duodenal ulcer (exacerbation), ulcerative colitis (exacerbation), Crohn's disease, diverticulitis, peptic ulcer, hemophilia. blood coagulation disorders, chronic renal failure, children's age (up to 6 years), pregnancy (III trimester). With caution. Anemia, asthma, alcoholism, tobacco smoking, alcoholic liver cirrhosis, hyperbilirubinemia, liver failure, diabetes mellitus, dehydration, sepsis, heart failure, edema, hypertension, blood diseases (including leukopenia), glucose-6-phosphate dehydrogen deficiency, glucose-6-phosphate dehydrogen stomatitis, advanced age, pregnancy (I, II trimester), lactation.
Use during pregnancy and lactation
The use of the drug in the third trimester of pregnancy is contraindicated.
The use of ketoprofen in the first and second trimesters of pregnancy is possible only if the potential benefit to the mother outweighs the risk to the fetus.
If you need to use ketoprofen during lactation, you should decide whether to stop breastfeeding.
Special instructions
During treatment, monitoring of the picture of peripheral blood and the functional state of the liver and kidneys is necessary.
If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.
Ketoprofen may mask signs of an infectious disease.
In case of impaired renal and hepatic function, dose reduction and close monitoring are necessary.
To reduce the risk of adverse events from the gastrointestinal tract, the minimum effective dose should be used with the lowest possible short course.
Influence on the ability to drive vehicles and control mechanisms
During treatment, care must be taken when driving vehicles and engaging in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.
Composition
Ketoprofen 50 mg.
Excipients: propylene glycol - 400 mg, ethanol - 100 mg, benzyl alcohol - 20 mg, sodium hydroxide solution 1M - up to pH 6.5-7.5, water d / i - up to 1 ml.
Dosage and administration
Prescribe i / m 100 mg 1-2 times / day. The maximum daily dose is 200 mg.
The drug should not be administered for more than 2-3 days, if necessary, continue to use other dosage forms of ketoprofen.
Side effects of the digestive system: NSAIDs, gastropathy, abdominal pain, dyspepsia (nausea, vomiting, heartburn, flatulence, decreased appetite, diarrhea), stomatitis, impaired liver function, ulceration of the gastrointestinal mucosa, gingival, gastrointestinal, hemorrhoidal bleeding, taste change.
From the nervous system: headache, dizziness, insomnia, agitation, nervousness, drowsiness, depression, asthenia, confusion or loss of consciousness, forgetfulness, migraine, peripheral neuropathy.
On the part of the sensory organs: noise or tinnitus, blurred visual perception, conjunctivitis, dry eyes, eye pain, conjunctival hyperemia, hearing loss, vertigo.
From the cardiovascular system: increased blood pressure, tachycardia.
From the hemopoietic organs: agranulocytosis, anemia, hemolytic anemia, thrombocytopenia, leukopenia.
From the urinary system: edematous syndrome, cystitis, urethritis, impaired renal function, interstitial nephritis, nephrotic syndrome, hematuria.
Allergic reactions: skin rash (including erythematous, urticaria), skin itching, rhinitis, angioedema, bronchospasm, exfoliative dermatitis, anaphylactic shock.
Other: increased sweating, hemoptysis, nosebleeds, myalgia, muscle twitching, shortness of breath, thirst, photosensitivity, with prolonged use in large doses - vaginal bleeding.
Drug Interactions
Pharmaceutically incompatible with tramadol solution.
Reduces the effectiveness of uricosuric drugs.
Enhances the action of anticoagulants, antiplatelet agents, fibrinolytics, ethanol, side effects of corticosteroids and mineralocorticosteroids, estrogens.
Reduces the effectiveness of antihypertensive drugs and diuretics.
Joint use with other NSAIDs, corticosteroids, ethanol, corticotropin can lead to ulceration and the development of gastrointestinal bleeding, to an increased risk of developing renal dysfunction.
Concomitant use with oral anticoagulants, heparin, thrombolytics, antiplatelet agents, cefoperazone, cefamandol and cefotetan increases the risk of bleeding.
Increases the hypoglycemic effect of insulin and oral hypoglycemic drugs (dose recalculation required).
Increases the plasma concentration of verapamil and nifedipine, lithium preparations, methotrexate.
Myelotoxic drugs increase the hematotoxicity of the drug.
Overdose
Symptoms: nausea, vomiting, abdominal pain, vomiting with blood, melena, impaired consciousness, respiratory depression, convulsions, impaired renal function, renal failure.
In case of overdose, symptomatic therapy, monitoring of respiratory and cardiovascular activity should be performed, use of histamine H2 receptor blockers, prostaglandin inhibitors is shown. There is no specific antidote. Hemodialysis is ineffective.
Storage conditions
The product should be stored out of the reach of children at a temperature not exceeding 25 РC.
Shelf life
2 years.
Deystvuyushtee substance
Ketoprofen
Dosage
solution for injection and infusion
Possible product names
KETOPROFEN 0.05 / ML 2ML N10 AMP R-R V / M / SYNTHESIS
Ketoprofml 50ml 2 ml 50ml 50ml Ketoprofen 50mg / ml solution d / intramuscularly. enter 2ml Amp. X10 B (R)
Ketoprofen 50mg / ml solution for iv and v / m administration. 2ml Amp. X10 (R)
Ketoprofen ampoules 0.05 / ml, 2 ml, 10 pcs.
Synthesis AKOMP, Russia
Intramuscular solution.
Packing
10 pcs.
Pharmacological action
Ketoprofen - NSAIDs, has anti-inflammatory, analgesic and antipyretic effects associated with the suppression of the activity of COX1 and COX2 that regulate the synthesis of Pg. Anti-inflammatory effect occurs at the end of 1 week of admission. Ketoprofen lysine salt has an equally pronounced anti-inflammatory, analgesic, antipyretic effect. It has no catabolic effect on articular cartilage.
Contraindications
Hypersensitivity (including to other NSAIDs), aspirin asthma, gastric and duodenal ulcer (exacerbation), ulcerative colitis (exacerbation), Crohn's disease, diverticulitis, peptic ulcer, hemophilia. blood coagulation disorders, chronic renal failure, children's age (up to 6 years), pregnancy (III trimester). With caution. Anemia, asthma, alcoholism, tobacco smoking, alcoholic liver cirrhosis, hyperbilirubinemia, liver failure, diabetes mellitus, dehydration, sepsis, heart failure, edema, hypertension, blood diseases (including leukopenia), glucose-6-phosphate dehydrogen deficiency, glucose-6-phosphate dehydrogen stomatitis, advanced age, pregnancy (I, II trimester), lactation.
Use during pregnancy and lactation
The use of the drug in the third trimester of pregnancy is contraindicated.
The use of ketoprofen in the first and second trimesters of pregnancy is possible only if the potential benefit to the mother outweighs the risk to the fetus.
If you need to use ketoprofen during lactation, you should decide whether to stop breastfeeding.
Special instructions
During treatment, monitoring of the picture of peripheral blood and the functional state of the liver and kidneys is necessary.
If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.
Ketoprofen may mask signs of an infectious disease.
In case of impaired renal and hepatic function, dose reduction and close monitoring are necessary.
To reduce the risk of adverse events from the gastrointestinal tract, the minimum effective dose should be used with the lowest possible short course.
Influence on the ability to drive vehicles and control mechanisms
During treatment, care must be taken when driving vehicles and engaging in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.
Composition
Ketoprofen 50 mg.
Excipients: propylene glycol - 400 mg, ethanol - 100 mg, benzyl alcohol - 20 mg, sodium hydroxide solution 1M - up to pH 6.5-7.5, water d / i - up to 1 ml.
Dosage and administration
Prescribe i / m 100 mg 1-2 times / day. The maximum daily dose is 200 mg.
The drug should not be administered for more than 2-3 days, if necessary, continue to use other dosage forms of ketoprofen.
Side effects of the digestive system: NSAIDs, gastropathy, abdominal pain, dyspepsia (nausea, vomiting, heartburn, flatulence, decreased appetite, diarrhea), stomatitis, impaired liver function, ulceration of the gastrointestinal mucosa, gingival, gastrointestinal, hemorrhoidal bleeding, taste change.
From the nervous system: headache, dizziness, insomnia, agitation, nervousness, drowsiness, depression, asthenia, confusion or loss of consciousness, forgetfulness, migraine, peripheral neuropathy.
On the part of the sensory organs: noise or tinnitus, blurred visual perception, conjunctivitis, dry eyes, eye pain, conjunctival hyperemia, hearing loss, vertigo.
From the cardiovascular system: increased blood pressure, tachycardia.
From the hemopoietic organs: agranulocytosis, anemia, hemolytic anemia, thrombocytopenia, leukopenia.
From the urinary system: edematous syndrome, cystitis, urethritis, impaired renal function, interstitial nephritis, nephrotic syndrome, hematuria.
Allergic reactions: skin rash (including erythematous, urticaria), skin itching, rhinitis, angioedema, bronchospasm, exfoliative dermatitis, anaphylactic shock.
Other: increased sweating, hemoptysis, nosebleeds, myalgia, muscle twitching, shortness of breath, thirst, photosensitivity, with prolonged use in large doses - vaginal bleeding.
Drug Interactions
Pharmaceutically incompatible with tramadol solution.
Reduces the effectiveness of uricosuric drugs.
Enhances the action of anticoagulants, antiplatelet agents, fibrinolytics, ethanol, side effects of corticosteroids and mineralocorticosteroids, estrogens.
Reduces the effectiveness of antihypertensive drugs and diuretics.
Joint use with other NSAIDs, corticosteroids, ethanol, corticotropin can lead to ulceration and the development of gastrointestinal bleeding, to an increased risk of developing renal dysfunction.
Concomitant use with oral anticoagulants, heparin, thrombolytics, antiplatelet agents, cefoperazone, cefamandol and cefotetan increases the risk of bleeding.
Increases the hypoglycemic effect of insulin and oral hypoglycemic drugs (dose recalculation required).
Increases the plasma concentration of verapamil and nifedipine, lithium preparations, methotrexate.
Myelotoxic drugs increase the hematotoxicity of the drug.
Overdose
Symptoms: nausea, vomiting, abdominal pain, vomiting with blood, melena, impaired consciousness, respiratory depression, convulsions, impaired renal function, renal failure.
In case of overdose, symptomatic therapy, monitoring of respiratory and cardiovascular activity should be performed, use of histamine H2 receptor blockers, prostaglandin inhibitors is shown. There is no specific antidote. Hemodialysis is ineffective.
Storage conditions
The product should be stored out of the reach of children at a temperature not exceeding 25 РC.
Shelf life
2 years.
Deystvuyushtee substance
Ketoprofen
Dosage
solution for injection and infusion
Possible product names
KETOPROFEN 0.05 / ML 2ML N10 AMP R-R V / M / SYNTHESIS
Ketoprofml 50ml 2 ml 50ml 50ml Ketoprofen 50mg / ml solution d / intramuscularly. enter 2ml Amp. X10 B (R)
Ketoprofen 50mg / ml solution for iv and v / m administration. 2ml Amp. X10 (R)
Ketoprofen ampoules 0.05 / ml, 2 ml, 10 pcs.
Synthesis AKOMP, Russia
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