Kestin tablets 10mg, No. 5

When administered orally, a single dose for adults is 10/20 mg, the frequency of administration is 1 time / day.

Lyophilized tablets, white or almost white, round. In 1 tablet: ebastine 10/20 mg Auxiliary substances: gelatin - 13 mg, mannitol - 9.76 mg, aspartame - 2 mg, mint flavor - 2 mg.

Pregnancy, lactation, hypersensitivity to piperidine derivatives.

A blocker of histamine H1 receptors from the group of piperidine derivatives. Provides antiallergic effect. It is characterized by a prolonged action (up to 48 hours), which is due to the formation of active metabolites. Unlike many blockers of histamine H1 receptors, ebastine has practically no m-anticholinergic activity, and also poorly penetrates the central nervous system and does not have a pronounced sedative effect.

Pharmacokinetics

Absorption is 90-95%. It is metabolized in the liver, turning into an active metabolite of karebastin. Fatty foods accelerate absorption (blood concentration increases 1.5 times) and presystemic metabolism (the formation of karebastin). Cmax after a single dose of 10 mg is achieved in 2.6-4 hours and is 80-100 ng / ml. Css is reached in 3-5 days and is 130-160 ng / ml. Plasma protein binding of ebastine and karebastin is 95%. T1 / 2 of karebastin - 15-19 hours, excreted by the kidneys - 60-70% in the form of conjugates. With renal failure, T1 / 2 increases to 23-26 hours, with liver failure - up to 27 hours.

Indications of active substances of the drug KestinЃ

Allergic rhinitis, allergic conjunctivitis, urticaria.

Dosage regimen

When administered orally, a single dose for adults is 10/20 mg, the frequency of administration is 1 time / day.

Side effect

Possibly: headache, dry mouth, drowsiness.

Rarely: abdominal pain, dyspepsia, nausea, asthenic syndrome, drowsiness, insomnia, rhinitis, sinusitis.

Contraindications for use

Pregnancy, lactation, hypersensitivity to piperidine derivatives.

Application during pregnancy and lactation

Ebastine is contraindicated during pregnancy and lactation (breastfeeding).

Application for violations of liver function

It is used with caution in patients with impaired liver and kidney function (in these cases, the T1 / 2 of ebastine increases significantly).

Application for impaired renal function

It is used with caution in patients with impaired liver and kidney function (in these cases, the T1 / 2 of ebastine increases significantly).

special instructions

It is used with caution in patients with impaired liver and kidney function (in these cases, the T1 / 2 of ebastine increases significantly). Influence on the ability to drive vehicles and control mechanisms In therapeutic doses, it does not affect the ability to drive a car and control mechanisms.

Drug interactions

Ebastine is not recommended to be used simultaneously with erythromycin and ketoconazole (increased risk of QT prolongation). Ebastine is compatible with theophylline, indirect anticoagulants, cimetidine, diazepam, ethanol and ethanol-containing drugs.