Kaltsypotryol | Dayvonex ointment 50 Ојg / g, 30 g

Latin name

daivonex

Release form

Ointment for external use.

Pharmacological action

Pharmacodynamics

The drug for the treatment of psoriasis.

Calcipotriol is a synthetic analogue of the active metabolite of vitamin D, stimulates morphological differentiation and inhibits the proliferation of keratinocytes, which underlies its therapeutic effect in psoriasis.

Calcipotriol is a potent inhibitor of T-lymphocyte activation caused by interleukin I.

The effect of calcipotriol on calcium metabolism is 100 times weaker than vitamin D3.

Pharmacokinetics

Transdermal absorption of calcipotriol is, depending on the dose used, from 1% to 5%. Calcipotriol undergoes rapid biotransformation in the liver with the formation of pharmacologically inactive metabolites. T 1/2 is very short.

Indications

Psoriasis vulgar, incl. chronic psoriasis of the scalp.

Contraindications

Hypersensitivity to the components of the drug.

Diseases accompanied by impaired calcium metabolism.

With caution, the drug should be used for: hypercalcemia, hypercalciuria, hypervitaminosis D, nephrolithiasis. In children due to lack of experience. In patients older than 65 years.

Use during pregnancy and lactation

The safety of the drug during pregnancy and lactation has not been established.

It is not known whether calcipotriol with breast milk is excreted.

Composition

1 g of ointment for external use contains:

Active ingredient: calcipotriol 50 mcg.

Excipients: disodium edetate, sodium hydrogen phosphate,? -tocopherol, liquid paraffin, polyethylene glycol stearate, propylene glycol, white paraffin, water.

Dosage and administration

Ointment is applied in a thin layer to the affected skin 2 times / day. The therapeutic effect is usually observed after 1-2 weeks from the start of treatment. The duration of the course of treatment is no more than 6-8 weeks.

For adults: the maximum daily dose is 15 g, the maximum dose per week is not more than 100 g.

For children over the age of 12 years: the maximum dose per week is 75 g.

For children aged 6 to 12 years: the maximum dose per week - no more than 50 g.

Side effects

Dermatological reactions: possible - local skin irritation, erythema and skin itching rarely - dermatitis, exacerbation of psoriasis in some cases - hyperpigmentation, photosensitivity.

From the side of metabolism: hypercalciuria, hypercalcemia.

Drug interaction

Divexone should not be used concomitantly with topical preparations containing salicylic acid.

overdose

Symptoms: Increased calcium levels in the blood may occur when using the drug at doses exceeding the recommended dose.

Treatment: Withdrawal.

Storage conditions

Store at a temperature not exceeding 25 РC.

Keep out of the reach of children.

Expiration

2 years.

Deystvuyuschee substances

Kaltsypotryol

dosage form

dosage form

ointment