Iron III Hydroxide Polymaltosate | Ferrum Lek chewable tablets 100 mg, 50 pcs.
Special Price
$20.24
Regular Price
$31.00
In stock
SKU
BID466306
Release form
chewable tablets
chewable tablets
Release form
chewable tablets
Packing
50 pcs.
Pharmacological action
Ferrum Lek - antianemic drug.
Pharmacodynamics
The molecular weight of the complex is so great - about 50 kDa - that its diffusion through the gastrointestinal mucosa is 40 times slower than diffusion of ferrous iron. The complex is stable and does not release iron ions under physiological conditions. The iron of the multi-core active zones of the complex is bound into a structure, similar to the structure of the natural compound of iron - ferritin. Due to this similarity, the iron of this complex is absorbed only by active absorption. Iron-binding proteins located on the surface of the intestinal epithelium absorb iron (III) from the complex through competitive ligand exchange. Absorbed iron is mainly deposited in the liver, where it binds to ferritin. Later in the bone marrow, it is included in hemoglobin.
The iron (III) complex polymaltose hydroxide does not have the prooxidant properties inherent in iron (II) salts.
Pharmacokinetics
Studies using the double isotope method (55Fe and 59Fe) showed that iron absorption, as measured by hemoglobin in red blood cells, is inversely proportional to the dose taken (the higher the dose, the lower the absorption). There is a statistically negative correlation between the degree of iron deficiency and the amount of iron absorbed (the higher the iron deficiency, the better the absorption). Iron is most absorbed in the duodenum and jejunum.
Indications
- treatment of latent iron deficiency
- treatment of iron deficiency anemia
- prevention of iron deficiency during pregnancy and lactation.
Contraindications
- hemosiderosis, hemochromatosis
- impaired iron utilization mechanisms (e.g., lead anemia, siderochrestic anemia)
- anemia, not associated with iron deficiency (e.g., hemolytic anemia, thalassemia).
Use during pregnancy and lactation
In controlled trials with the use of the drug in the second and third trimesters of pregnancy, there was no negative effect on the mother or fetus. There were no harmful effects on the fetus when using the drug in the first trimester of pregnancy.
Special instructions
When prescribing Ferrum Lek to patients with diabetes mellitus, it should be borne in mind that 1 tablet and 1 ml of syrup contains 0.04 XE.
No drug interaction with various foods: cereals (phytin), vegetables (oxalates), tea (tannins), as Iron is part of the complex compound and does not enter into ionic interaction.
Taking the drug does not affect the results of feces for occult blood (selective for hemoglobin), so there is no need to stop taking the drug before the study.
Composition
1 chewable tablet contains:
active substance: iron (in the form of iron (III) hydroxide polymaltose) 100 mg
excipients: chocolate essence, aspartame (E951), talc, macrogol 6000, dextrates
Dosage and administration of
For the treatment of iron deficiency anemia, 1 tab. 2-3 times / day until a normal hemoglobin level in the blood is reached (usually 2-3 months after the start of therapy). After this, the intake of iron preparations should be continued for several months to restore the reserve of iron in the body (1 tab. 1 time / day).
During pregnancy, it is recommended to take 1 tablet / day for the entire period.
For the treatment of latent iron deficiency and the prevention of iron deficiency is prescribed at a dose of 1 tab./day.
Tablets are recommended to be taken during or immediately after a meal, chewing them or swallowing whole.
Side effects of
From the digestive system: rarely - a feeling of heaviness, discomfort in the stomach, nausea, constipation, diarrhea. When taking the drug, staining of feces in a dark color is noted, which is due to the removal of non-absorbed iron and does not have clinical significance.
Drug interaction
No interaction with other drugs or food products has been identified.
Concomitant use with parenteral iron preparations and other oral iron (III) preparations, polymaltosate hydroxide is not recommended due to marked inhibition of absorption of oral iron.
overdose
Symptoms: no signs of intoxication or excess iron in the body were observed with an overdose of Ferrum Lek syrup or chewable tablets. The iron of the active substance is not present in the gastrointestinal tract in free form and is not absorbed by passive diffusion.
Treatment: symptomatic, as an antidote, is administered intravenously slowly (15 mg / kg / h) of Deferoxamine, depending on the severity of the overdose, but not more than 80 mg / kg / day. Hemodialysis is ineffective.
Storage conditions
The product should be stored out of the reach of children at a temperature not exceeding 25 РC.
Shelf life
3 years.
Deystvuyushtee substance
irons III gidroksid polimalytozat
Terms and conditions otpuska from
pharmacies prescription
dosage form
lozenges
Possible product names
Ferrum Lek 100mg Tab. chewing X50 (R)
Ferrum Lek 100mg No. 50 tab
FERRUM LEC ZHEV. TAB. 100MG No. 50
Ferrum Lek tabzhev 100mg N50 (blister N10x5)
Ferrum Lek tabzhev 100mg N50 (strip N10x5)
Sandoz, Switzerland
chewable tablets
Packing
50 pcs.
Pharmacological action
Ferrum Lek - antianemic drug.
Pharmacodynamics
The molecular weight of the complex is so great - about 50 kDa - that its diffusion through the gastrointestinal mucosa is 40 times slower than diffusion of ferrous iron. The complex is stable and does not release iron ions under physiological conditions. The iron of the multi-core active zones of the complex is bound into a structure, similar to the structure of the natural compound of iron - ferritin. Due to this similarity, the iron of this complex is absorbed only by active absorption. Iron-binding proteins located on the surface of the intestinal epithelium absorb iron (III) from the complex through competitive ligand exchange. Absorbed iron is mainly deposited in the liver, where it binds to ferritin. Later in the bone marrow, it is included in hemoglobin.
The iron (III) complex polymaltose hydroxide does not have the prooxidant properties inherent in iron (II) salts.
Pharmacokinetics
Studies using the double isotope method (55Fe and 59Fe) showed that iron absorption, as measured by hemoglobin in red blood cells, is inversely proportional to the dose taken (the higher the dose, the lower the absorption). There is a statistically negative correlation between the degree of iron deficiency and the amount of iron absorbed (the higher the iron deficiency, the better the absorption). Iron is most absorbed in the duodenum and jejunum.
Indications
- treatment of latent iron deficiency
- treatment of iron deficiency anemia
- prevention of iron deficiency during pregnancy and lactation.
Contraindications
- hemosiderosis, hemochromatosis
- impaired iron utilization mechanisms (e.g., lead anemia, siderochrestic anemia)
- anemia, not associated with iron deficiency (e.g., hemolytic anemia, thalassemia).
Use during pregnancy and lactation
In controlled trials with the use of the drug in the second and third trimesters of pregnancy, there was no negative effect on the mother or fetus. There were no harmful effects on the fetus when using the drug in the first trimester of pregnancy.
Special instructions
When prescribing Ferrum Lek to patients with diabetes mellitus, it should be borne in mind that 1 tablet and 1 ml of syrup contains 0.04 XE.
No drug interaction with various foods: cereals (phytin), vegetables (oxalates), tea (tannins), as Iron is part of the complex compound and does not enter into ionic interaction.
Taking the drug does not affect the results of feces for occult blood (selective for hemoglobin), so there is no need to stop taking the drug before the study.
Composition
1 chewable tablet contains:
active substance: iron (in the form of iron (III) hydroxide polymaltose) 100 mg
excipients: chocolate essence, aspartame (E951), talc, macrogol 6000, dextrates
Dosage and administration of
For the treatment of iron deficiency anemia, 1 tab. 2-3 times / day until a normal hemoglobin level in the blood is reached (usually 2-3 months after the start of therapy). After this, the intake of iron preparations should be continued for several months to restore the reserve of iron in the body (1 tab. 1 time / day).
During pregnancy, it is recommended to take 1 tablet / day for the entire period.
For the treatment of latent iron deficiency and the prevention of iron deficiency is prescribed at a dose of 1 tab./day.
Tablets are recommended to be taken during or immediately after a meal, chewing them or swallowing whole.
Side effects of
From the digestive system: rarely - a feeling of heaviness, discomfort in the stomach, nausea, constipation, diarrhea. When taking the drug, staining of feces in a dark color is noted, which is due to the removal of non-absorbed iron and does not have clinical significance.
Drug interaction
No interaction with other drugs or food products has been identified.
Concomitant use with parenteral iron preparations and other oral iron (III) preparations, polymaltosate hydroxide is not recommended due to marked inhibition of absorption of oral iron.
overdose
Symptoms: no signs of intoxication or excess iron in the body were observed with an overdose of Ferrum Lek syrup or chewable tablets. The iron of the active substance is not present in the gastrointestinal tract in free form and is not absorbed by passive diffusion.
Treatment: symptomatic, as an antidote, is administered intravenously slowly (15 mg / kg / h) of Deferoxamine, depending on the severity of the overdose, but not more than 80 mg / kg / day. Hemodialysis is ineffective.
Storage conditions
The product should be stored out of the reach of children at a temperature not exceeding 25 РC.
Shelf life
3 years.
Deystvuyushtee substance
irons III gidroksid polimalytozat
Terms and conditions otpuska from
pharmacies prescription
dosage form
lozenges
Possible product names
Ferrum Lek 100mg Tab. chewing X50 (R)
Ferrum Lek 100mg No. 50 tab
FERRUM LEC ZHEV. TAB. 100MG No. 50
Ferrum Lek tabzhev 100mg N50 (blister N10x5)
Ferrum Lek tabzhev 100mg N50 (strip N10x5)
Sandoz, Switzerland
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