interferon alfa-2b, metronidazole, fluconazole | vagiferon 10 pieces.

Latin name

Vagiferon



vaginal suppositories



packaging 10 pcs

Pharmacological action

Wagiferon - a combined preparation for intravaginal use.

Wagiferon has antiviral, immunomodulatory, anti-inflammatory, antifungal, antimicrobial and antiprotozoal (trichomonacid) effects.

- Interferon alfa-2b has pronounced antiviral, immunomodulatory properties.

- Metronidazole is an antiprotozoal and antibacterial drug derived from 5-nitroimidazole. The mechanism of action is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of the cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria. Active against Trichomonas vaginalis, Gardnerella vaginalis, as well as gram-negative anaerobes Bacteroides spp. (including B. fragilis, B. distasonis, B. status, B. thetaiotaomicron, B. vulgaris), Fusobacterium spp. and some gram-positive anaerobes (sensitive strains of Eubacterium spp., Clostridium spp., Peptococcus niger, Peptostreptococcus spp., Mobiluncus spp.). Aerobic microorganisms and facultative anaerobes are insensitive to metronidazole.

- Fluconazole has a highly specific fungicidal (antifungal) effect. Active with mycoses, incl. caused by Candida spr. (including generalized forms of candidiasis against the background of immunosuppression), Cryptococcus neoformans and Coccidioides immitis, Microsporum spp., Blastoyces dermatitidis. With intravaginal administration, it is especially active against Candida albicans, to a lesser extent in relation to Candida glabrata.

Indications

bacterial vaginosis

bacterial (nonspecific) vaginitis

vaginitis caused by mixed infection (Trichomonas, Gardenerella, yeast-like fungi, herpes simplex virus type 1 and 2, mycoplasma, ureaplasma) as part of complex therapy.

Contraindications

pregnancy

children under 18 years of age (efficacy and safety of the drug have not been established)

hypersensitivity to the components of the drug vagiferon (including derivatives of nitroimidazole).

Use during pregnancy and lactation

The drug is not used during pregnancy.

Metronidazole passes into breast milk. Breastfeeding while taking the drug should be canceled. Breastfeeding should be resumed no earlier than 48 hours after the end of the drug.

Dosage and administration of

Intravaginally. 1 suppository in the evening (before bedtime), for 10 days.

Side effects

When applied topically, no side effects were detected. In some cases, allergic reactions and local reactions are possible.

Side effects specific to metronidazole, since its systemic absorption is 56%: allergic reactions (rare), leukopenia, ataxia, mental changes (anxiety, lability of mood), cramps, rarely: diarrhea, constipation, dizziness, headache, loss of appetite, nausea, vomiting, pain and cramping abdomen, taste change (rare), dry mouth, metallic or unpleasant aftertaste, increased fatigue.

Drug Interaction

Not recommended for combination with non-depolarizing muscle relaxants (vecuronium bromide).

Possible co-administration with antibiotic-macrolide (jazzamycin) systemic action.

Overdose

No cases of overdose have been detected. With an overdose of metronidazole, nausea, vomiting, abdominal pain, diarrhea, itching, a metallic taste in the mouth, ataxia, dizziness, paresthesias, convulsions, leukopenia, dark staining of urine.

Storage conditions

At a temperature of 2 РC to 8 РC. Keep out of the reach of children.

Expiration

2 years.

Pharmacy

Prescription

dosage form

dosage form

vaginal suppositories

Firn M, Russia