Influnet Lime powder for preparation of oral solution, No. 10

Symptomatic treatment of 'colds' and flu, accompanied by fever, headache, chills, nasal congestion, sore throat and sinuses.

The drug is administered orally after meals - 1 sachet at intervals of 4-6 hours, but no more than 4 times / day, for 3 days. The maximum daily dose is 4 sachets.

If within 3 days after the start of treatment there is no improvement in well-being, the patient should stop taking the drug and consult a doctor.

The contents of 1 sachet must be dissolved in a glass of boiled hot water and taken hot.

Stir before use.

Powder for preparation of oral solution [cranberry, lime, wild berries, raspberry, mint] in the form of a mixture of powder and / or granules from light yellow to yellow with a greenish tinge, with the smell of cranberries or lime, or forest berries, or raspberries , or mint; prepared solution * - cloudy, with a yellowish-greenish tinge, with the smell of cranberries or limes, or forest berries, or raspberries, or mint; the presence of undissolved yellow particles is allowed.

1 pack. (5 g)

• paracetamol 350 mg

• ascorbic acid 300 mg

• succinic acid 120 mg

• rutoside (in the form of trihydrate) 20 mg

• phenylephrine hydrochloride 5 mg

Excipients: cranberry flavor or lime flavor, or forest berry flavor, or raspberry flavor, or mint flavor - 60 mg, aspartame - 30 mg, hyprolose - 30 mg, colloidal silicon dioxide - 10 mg, lactose monohydrate - 4075 mg.

• Hypersensitivity to the components of the drug;

• severe liver disease (including acute hepatitis or exacerbation of chronic diseases);

• severe kidney disease (including acute pyelonephritis, acute glomerulonephritis or exacerbation of chronic diseases);

• peptic ulcer of the stomach and duodenum;

• glaucoma;

• tendency to thrombosis;

• diabetes;

• arterial hypertension;

• bradycardia;

• ventricular tachycardia, conduction disturbances, ventricular fibrillation;

• heart failure;

• severe atherosclerosis;

• severe aortic stenosis;

• acute myocardial infarction;

• pheochromocytoma;

• hyperthyroidism;

• hyperplasia of the prostate;

• simultaneous administration of tricyclic antidepressants, beta-blockers, MAO inhibitors (including within 14 days after their cancellation), other medicines containing paracetamol;

• lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome (due to the presence of lactose in the composition);

• phenylketonuria (powder for the preparation of a solution for oral administration - due to the presence of aspartame in the composition);

• pregnancy;

• lactation period (breastfeeding);

• children and adolescents up to 18 years old.

The drug should be used with caution in patients with benign hyperbilirubinemia, congenital deficiency of glucose-6-phosphate dehydrogenase.

pharmachologic effect

The combined preparation has antipyretic, analgesic, angioprotective, anti-edema effect.

Paracetamol has an antipyretic, analgesic effect.

Ascorbic acid (vitamin C) is involved in the regulation of carbohydrate metabolism, redox processes, the synthesis of steroid hormones, tissue regeneration, activates immune responses, reduces capillary permeability, enhances the detoxification function of the liver, and regulates blood coagulation processes. Replenishes vitamin C deficiency in case of colds.

Succinic acid enhances biochemical and physiological recovery processes. It has hepatoprotective, immunomodulatory and antioxidant effects. It activates energy processes in mitochondria, normalizes the permeability of cell membranes, is an intermediate of the Krebs cycle. In combination with drugs, it enhances their positive effect and reduces the manifestation of toxic effects.

Rutoside reduces capillary permeability, relieves swelling and inflammation, strengthens the vascular wall, inhibits aggregation and increases the degree of erythrocyte deformation.

Phenylephrine stimulates postsynaptic ?-adrenergic receptors, reduces edema and hyperemia of the nasal mucosa, restores free breathing, and reduces pressure in the paranasal sinuses and middle ear.

Side effect

When used in recommended doses, the drug is well tolerated, side effects are extremely rare.

From the hematopoietic system: agranulocytosis, thrombocytopenia, thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, anemia.

From the side of the cardiovascular system: increased blood pressure, bradycardia, arrhythmia, angina pectoris.

From the nervous system: headache, agitation, irritability, anxiety, weakness, dizziness, respiratory depression, tremor.

From the digestive system: nausea, vomiting, diarrhea.

From the side of metabolism: metabolic disorders, inhibition of glycogen synthesis, excessive formation of corticosteroids, sodium and water retention, hypokalemia.

From the urinary system: an increase or decrease in urine output, damage to the glomerular apparatus of the kidneys, the formation of oxalate urinary stones.

Allergic reactions: skin rashes, hyperemia.

If any of the side effects indicated in the instructions are aggravated or other side effects not indicated in the instructions appear, the patient should inform the doctor about it.

Application during pregnancy and lactation

The use of the drug during pregnancy and lactation (breastfeeding) is contraindicated.

Application for violations of liver function

The use of the drug is contraindicated in severe liver diseases (including acute hepatitis or exacerbation of chronic diseases).

Application for impaired renal function

The use of the drug is contraindicated in severe kidney diseases (including acute pyelonephritis, acute glomerulonephritis or exacerbation of chronic diseases).

Application in children

The use of the drug in children and adolescents under 18 years of age is contraindicated.

special instructions

The duration of the drug use without consulting a doctor should not exceed 3 days.

When using the drug, it is possible to distort the results of laboratory tests that assess the concentration of glucose and uric acid in plasma.

Persons prone to alcohol consumption should consult a doctor before starting treatment with InflunetЃ, as paracetamol can have a liver damaging effect.

Overdose

Symptoms (overdose is mainly caused by paracetamol): pallor of the skin, anorexia, nausea, vomiting and abdominal pain, increased activity of hepatic transaminases, increased prothrombin time, hepatonecrosis, arrhythmia, ventricular tachycardia, increased blood pressure.

Treatment: at the prehospital stage - gastric lavage, the appointment of activated charcoal, symptomatic therapy. The antidote to paracetamol is acetylcysteine. In case of overdose, the patient should consult a doctor.

Drug interactions

Stimulants of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites of paracetamol, which makes it possible to develop severe intoxications with a slight overdose.

Paracetamol enhances the effects of MAO inhibitors, sedatives, ethanol.

Antidepressants, antiparkinsonian, antipsychotic drugs, phenothiazine derivatives increase the risk of urinary retention, dry mouth, constipation.

GCS, when used simultaneously with the drug, increase the risk of developing glaucoma.

Phenylephrine reduces the hypotensive effect of guanethidine.

Guanethidine enhances the alpha-adrenostimulating effect, and tricyclic antidepressants enhance the sympathomimetic effect of phenylephrine.

If it is necessary to take InflunetЃ together with other medicines, the patient should consult with the attending physician.