indometacin indometacin | Indomectacin 100 mg 10 mg Berlin-Rezit 100 Berlin .
Special Price
$20.37
Regular Price
$28.00
In stock
SKU
BID470346
Release form
Rectal suppositories
Rectal suppositories
Release form
Rectal suppositories
Packing
10 pcs.
Pharmacological action of
Indomethacin has anti-inflammatory, analgesic and antipyretic effects, as well as some antiplatelet effect.
Suppresses the activity of anti-inflammatory factors, reduces platelet aggregation.
Inhibiting cyclooxygenase 1 and 2, disrupts the metabolism of arachidonic acid, reduces the amount of prostaglandins (Pg) both in the focus of inflammation and in healthy tissues, and suppresses the exudative and proliferative phases of inflammation.
Indications
Joint syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout), pain in the spine, neuralgia, myalgia, traumatic inflammation of the soft tissues and joints, rheumatism, diffuse diseases of the connective tissue, dysmenorrhea.
As an adjunct in infectious and inflammatory diseases of the ENT organs, adnexitis, prostatitis, cystitis.
Contraindications
- Individual hypersensitivity to indomethacin, aspirin or other NSAIDs (history of bronchospasm, urticaria or rhinitis, caused by the intake of acetylsalicylic acid or other NSAIDs)
- peptic ulcer of the stomach and / or intestines in the acute phase
- pregnancy and lactation
- children's age (up to 14 years).
- hematopoiesis disorders
- severe impaired liver and / or kidney function
- severe forms of chronic heart failure, arterial hypertension, pancreatitis
- for rectal administration: proctitis, recent rectal bleeding.
Special instructions
Use with caution in elderly patients, as well as in diseases of the liver, kidneys, gastrointestinal tract in the anamnesis, with dyspeptic symptoms at the time of use, arterial hypertension, heart failure, immediately after serious surgery, with parkinsonism, epilepsy.
For indications of a history of allergic reactions, NSAIDs are used only in urgent cases.
During the treatment period, systematic monitoring of liver and kidney function and the picture of peripheral blood is necessary.
Concomitant use with acetylsalicylic acid and other NSAIDs is not recommended.
Indomethacin should not be used concurrently with diflunisal.
With the simultaneous use of indomethacin with lithium preparations, the possibility of symptoms of the toxic effects of lithium should be borne in mind.
Influence on the ability to drive vehicles and operate machinery
During treatment, one should refrain from potentially dangerous activities, associated with the need for concentration and increased speed of psychomotor reactions.
Composition
1 suppository contains indomethacin 100 mg
Dosage and administration
Rectally (injected into the rectum). Before using the suppository, it is recommended to empty the intestines.
Wash your hands, free the suppository from the contour packaging, cutting it with scissors or opening it with your hands, Pulling at the opposite ends of the edges of the contour packaging, and enter the suppository into the anus with a pointed end, as deep as possible.
For more convenient use of the suppository, it is recommended to bend down or sit down, you can enter lying on your side.
Suppositories 100 mg - 1 time per day
During an attack of gout, up to 200 mg per day.
Recommended for use at night.
Side effects of the
Digestive system: nausea, anorexia, vomiting, abdominal pain and discomfort, constipation or diarrhea, erosive-ulcerative lesions, bleeding and perforation of the gastrointestinal tract rarely - intestinal strictures, stomatitis, gastritis, flatulence, bleeding from the sigmoid colon or from a diverticulum, jaundice, hepatitis.
From the side of the central nervous system and peripheral nervous system: dizziness, headache, depression, feeling of fatigue rarely - anxiety, fainting, drowsiness, cramps, peripheral neuropathy, muscle weakness, involuntary muscle movements, sleep disturbances, mental disorders (depersonalization, psychotic episodes), paresthesia, dysarthria, parkinsonism.
From the cardiovascular system: edema, increased blood pressure, tachycardia, chest pain, arrhythmia, palpitation, arterial hypotension, congestive heart failure, hematuria.
Allergic reactions: rarely - itching, urticaria, angiitis, erythema nodosum, skin rash, exfoliative dermatitis, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, hair loss, acute respiratory distress, a sharp drop in blood pressure, anaphylactic reactions, angioedema, dyspnea, bronchial asthma, pulmonary edema.
From the hemopoietic system: rarely - leukopenia, petechiae or ecchymosis, purpura, aplastic and hemolytic anemia, thrombocytopenia, DIC.
On the part of the sensory organs: rarely - violation of the clarity of visual perception, diplopia, orbital and periorbital pain, tinnitus, hearing impairment, deafness.
From the urinary system: rarely - proteinuria, nephrotic syndrome, interstitial nephritis, impaired renal function, renal failure.
From the side of metabolism: rarely - hyperglycemia, glucosuria, hyperkalemia.
Other: rarely - vaginal bleeding, hot flashes, excessive sweating, nosebleeds, breast enlargement and tension, gynecomastia.
Drug interaction
With the simultaneous use of indomethacin, it can reduce the effects of saluretics, beta-blockers and enhance the effects of indirect anticoagulants.
With the simultaneous use of indomethacin and diflunisal, there is a risk of severe bleeding from the gastrointestinal tract.
With simultaneous use with probenecid, an increase in the plasma concentration of indomethacin is possible.
Indomethacin may decrease tubular secretion of methotrexate, resulting in increased toxicity.
When used concomitantly with NSAIDs, the toxicity of cyclosporine increases.
Indomethacin at a dose of 50 mg 3 times / day increases the concentration of lithium in the blood plasma and reduces the clearance of lithium from the body in patients with mental illness.
With the simultaneous use of indomethacin with digoxin, an increase in the concentration of digoxin in the blood plasma and an increase in the half-life of digoxin are possible.
Overdose
Symptoms: nausea, vomiting, severe headache, dizziness, impaired memory, disorientation. In severe cases of paresthesia, numbness of the limbs, convulsions.
Treatment: symptomatic therapy. Hemodialysis is ineffective.
Terms and conditions
prescription
Berlin-Chemie / Menarini Germany
Rectal suppositories
Packing
10 pcs.
Pharmacological action of
Indomethacin has anti-inflammatory, analgesic and antipyretic effects, as well as some antiplatelet effect.
Suppresses the activity of anti-inflammatory factors, reduces platelet aggregation.
Inhibiting cyclooxygenase 1 and 2, disrupts the metabolism of arachidonic acid, reduces the amount of prostaglandins (Pg) both in the focus of inflammation and in healthy tissues, and suppresses the exudative and proliferative phases of inflammation.
Indications
Joint syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout), pain in the spine, neuralgia, myalgia, traumatic inflammation of the soft tissues and joints, rheumatism, diffuse diseases of the connective tissue, dysmenorrhea.
As an adjunct in infectious and inflammatory diseases of the ENT organs, adnexitis, prostatitis, cystitis.
Contraindications
- Individual hypersensitivity to indomethacin, aspirin or other NSAIDs (history of bronchospasm, urticaria or rhinitis, caused by the intake of acetylsalicylic acid or other NSAIDs)
- peptic ulcer of the stomach and / or intestines in the acute phase
- pregnancy and lactation
- children's age (up to 14 years).
- hematopoiesis disorders
- severe impaired liver and / or kidney function
- severe forms of chronic heart failure, arterial hypertension, pancreatitis
- for rectal administration: proctitis, recent rectal bleeding.
Special instructions
Use with caution in elderly patients, as well as in diseases of the liver, kidneys, gastrointestinal tract in the anamnesis, with dyspeptic symptoms at the time of use, arterial hypertension, heart failure, immediately after serious surgery, with parkinsonism, epilepsy.
For indications of a history of allergic reactions, NSAIDs are used only in urgent cases.
During the treatment period, systematic monitoring of liver and kidney function and the picture of peripheral blood is necessary.
Concomitant use with acetylsalicylic acid and other NSAIDs is not recommended.
Indomethacin should not be used concurrently with diflunisal.
With the simultaneous use of indomethacin with lithium preparations, the possibility of symptoms of the toxic effects of lithium should be borne in mind.
Influence on the ability to drive vehicles and operate machinery
During treatment, one should refrain from potentially dangerous activities, associated with the need for concentration and increased speed of psychomotor reactions.
Composition
1 suppository contains indomethacin 100 mg
Dosage and administration
Rectally (injected into the rectum). Before using the suppository, it is recommended to empty the intestines.
Wash your hands, free the suppository from the contour packaging, cutting it with scissors or opening it with your hands, Pulling at the opposite ends of the edges of the contour packaging, and enter the suppository into the anus with a pointed end, as deep as possible.
For more convenient use of the suppository, it is recommended to bend down or sit down, you can enter lying on your side.
Suppositories 100 mg - 1 time per day
During an attack of gout, up to 200 mg per day.
Recommended for use at night.
Side effects of the
Digestive system: nausea, anorexia, vomiting, abdominal pain and discomfort, constipation or diarrhea, erosive-ulcerative lesions, bleeding and perforation of the gastrointestinal tract rarely - intestinal strictures, stomatitis, gastritis, flatulence, bleeding from the sigmoid colon or from a diverticulum, jaundice, hepatitis.
From the side of the central nervous system and peripheral nervous system: dizziness, headache, depression, feeling of fatigue rarely - anxiety, fainting, drowsiness, cramps, peripheral neuropathy, muscle weakness, involuntary muscle movements, sleep disturbances, mental disorders (depersonalization, psychotic episodes), paresthesia, dysarthria, parkinsonism.
From the cardiovascular system: edema, increased blood pressure, tachycardia, chest pain, arrhythmia, palpitation, arterial hypotension, congestive heart failure, hematuria.
Allergic reactions: rarely - itching, urticaria, angiitis, erythema nodosum, skin rash, exfoliative dermatitis, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, hair loss, acute respiratory distress, a sharp drop in blood pressure, anaphylactic reactions, angioedema, dyspnea, bronchial asthma, pulmonary edema.
From the hemopoietic system: rarely - leukopenia, petechiae or ecchymosis, purpura, aplastic and hemolytic anemia, thrombocytopenia, DIC.
On the part of the sensory organs: rarely - violation of the clarity of visual perception, diplopia, orbital and periorbital pain, tinnitus, hearing impairment, deafness.
From the urinary system: rarely - proteinuria, nephrotic syndrome, interstitial nephritis, impaired renal function, renal failure.
From the side of metabolism: rarely - hyperglycemia, glucosuria, hyperkalemia.
Other: rarely - vaginal bleeding, hot flashes, excessive sweating, nosebleeds, breast enlargement and tension, gynecomastia.
Drug interaction
With the simultaneous use of indomethacin, it can reduce the effects of saluretics, beta-blockers and enhance the effects of indirect anticoagulants.
With the simultaneous use of indomethacin and diflunisal, there is a risk of severe bleeding from the gastrointestinal tract.
With simultaneous use with probenecid, an increase in the plasma concentration of indomethacin is possible.
Indomethacin may decrease tubular secretion of methotrexate, resulting in increased toxicity.
When used concomitantly with NSAIDs, the toxicity of cyclosporine increases.
Indomethacin at a dose of 50 mg 3 times / day increases the concentration of lithium in the blood plasma and reduces the clearance of lithium from the body in patients with mental illness.
With the simultaneous use of indomethacin with digoxin, an increase in the concentration of digoxin in the blood plasma and an increase in the half-life of digoxin are possible.
Overdose
Symptoms: nausea, vomiting, severe headache, dizziness, impaired memory, disorientation. In severe cases of paresthesia, numbness of the limbs, convulsions.
Treatment: symptomatic therapy. Hemodialysis is ineffective.
Terms and conditions
prescription
Berlin-Chemie / Menarini Germany
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