Indinol Forto capsules 200mg, No. 60

Inside, 2 times / day, 200 mg. The daily dose is 400 mg. The duration of the course of treatment is 6 months.

Capsules are hard, gelatinous, size No. 0, with a white body and an orange cap. Capsule content: powder from white to light yellow or light brown.

1 caps.

indole carbinol 0.2 g

Excipients: lactose monohydrate (milk sugar) - 0.14 g, modified corn starch - 0.095 g, microcrystalline cellulose - 0.064 g, magnesium stearate - 0.001 g.

• Hypersensitivity to the components of the drug;

• pregnancy, lactation period;

• age up to 18 years

pharmachologic effect

Selective estrogen receptor modulator. It has antiestrogenic and antiproliferative effects. Causes selective death of breast cells with abnormally high proliferative activity.

Indolecarbinol modulates the cytochrome system in such a way that the resulting isoform of cytochrome P450 - CYP1A1 hydroxylates estrogens in the 2nd position, with the formation of 2-hydroxyestrone (2-OHE1). The resulting metabolite is an antagonist of the estrogen receptor and blocks its activation by the estrogens themselves, as well as by their dangerous metabolites, in particular, 16 -? - hydroxyestrone (16? - OHE1), the proportion of which among the metabolites decreases. This suppresses the induction of estrogen-dependent genes and the cell ceases to receive excessive estrogen-dependent stimulation. The drug also blocks other signaling mechanisms (cytokine) that stimulate abnormal cell growth in breast tissues by suppressing signaling cascades from the corresponding receptors.

Course use of indole carbinol helps to reduce the intensity and disappear pain in the mammary gland with cyclic mastalgia (mastodynia).

Side effect

On the part of the reproductive system: menstrual irregularities in the form of lengthening or shortening.

From the digestive system: epigastric pain.

Laboratory indicators: an increase in the concentration of TSH and FSH, prolactin and estradiol, a decrease in the concentration of creatinine, eosinophilia.

Other: weight loss.

Application during pregnancy and lactation

Use during pregnancy and lactation is contraindicated.

Application in children

The use is contraindicated under the age of 18 years.

Drug interactions

Considering the effect of indole carbinol on the activity of cytochrome P450 isoenzymes, caution should be exercised when combined with drugs, in the metabolism of which cytochrome P450 isoenzymes are involved (indirect anticoagulants, corticosteroids, oral hypoglycemic agents, antiarrhythmic and antiepileptic drugs, drugs foxglove) .to. dose adjustment may be required.