Hypothiazide tablets 100mg, No. 20

arterial hypertension (used both in monotherapy and in combination with other antihypertensive drugs);

edematous syndrome of various origins (chronic heart failure, nephrotic syndrome, premenstrual syndrome, acute glomerulonephritis, chronic renal failure, portal hypertension, corticosteroid treatment);

control of polyuria, mainly in nephrogenic diabetes insipidus;

prevention of the formation of stones in the genitourinary tract in predisposed patients (reduction of hypercalciuria).

Inside, after eating.

The dosage should be selected individually. With constant medical supervision, the minimum effective dose is established.

Due to the increased loss of potassium and magnesium ions during treatment (the serum potassium level may decrease below 3.0 mmol / l), it becomes necessary to replace potassium and magnesium.

Adults. As an antihypertensive agent, the usual starting daily dose is 25-50 mg once, as monotherapy or in combination with other antihypertensive agents. For some patients, an initial dose of 12.5 mg is sufficient, both as monotherapy and in combination. It is necessary to use the minimum effective dose not exceeding 100 mg / day. If HypothiazidЃ is combined with other antihypertensive drugs, it may be necessary to reduce the dose of another drug in order to prevent an excessive decrease in blood pressure.

The antihypertensive effect appears within 3-4 days, but it may take up to 3-4 weeks to achieve the optimal effect. After the end of treatment, the hypotensive effect persists for 1 week.

Edematous syndrome of various origins. The usual starting dose for the treatment of edema is 25Ц100 mg of the drug once a day or once every 2 days. Depending on the clinical response, the dose can be reduced to 25-50 mg once a day or once every 2 days. In some severe cases, doses of up to 200 mg / day may be required at the beginning of treatment.

In premenstrual syndrome, the usual dose is 25 mg / day and is used from the onset of symptoms to the onset of menstruation.

In nephrogenic diabetes insipidus, the usual daily dose of 50Ц150 mg (in divided doses) is recommended.

Children. Doses should be adjusted based on the weight of the child. The usual pediatric daily doses are 1Ц2 mg / kg or 30Ц60 mg / m2 body surface area, given once daily. The total daily dose for children aged 3 to 12 years is 37.5-100 mg.

in a blister 20 pcs.; in a cardboard box 1 blister.

hypersensitivity to the drug or to other sulfonamides;

anuria;

severe renal (Cl creatinine - less than 30 ml / min) or liver failure;

difficult to control diabetes mellitus;

Addison's disease:

refractory hypokalemia, hyponatremia, hypercalcemia;

children under 3 years of age (solid dosage form).

Use with caution in hypokalemia, hyponatremia, hypercalcemia, in patients with coronary artery disease, with cirrhosis of the liver, gout, in the elderly, in patients suffering from lactose intolerance, while taking cardiac glycosides.