Hydroxyzin tablets 25mg, No. 25

Hydroxyzin tablets 25mg, No. 25; 'Neuroses and neurotic conditions, manifested by increased excitability, feelings of emotional stress, anxiety; organic lesions of the central nervous system, accompanied by increased excitability; withdrawal symptoms in chronic alcoholism; premedication before surgery, prevention and relief of vomiting in the postoperative period; skin itching.

For oral administration, a single dose for adults ranges from 25 mg to 100 mg; the frequency of admission, depending on the indications, is 1-4 times / day. To quickly achieve a therapeutic effect, the hydroxyzine solution is injected deeply intramuscularly at a dose of 50-100 mg; then you can enter at intervals of 4-6 hours.

active substance: hydroxyzine hydrochloride

Porphyria, benign prostatic hyperplasia, angle-closure glaucoma, labor, pregnancy, lactation, hypersensitivity to hydroxyzine, labor.

pharmachologic effect

Anxiolytic and sedative, histamine H1 receptor blocker, piperazine derivative. It has a moderate m-anticholinergic activity. It has an antiemetic effect.

Pharmacokinetics

Possesses high absorption. Cmax after oral administration is achieved after 2 hours; T1 / 2 in adults is 12-20 hours, in children - 7 hours. Metabolites are found in breast milk.

Side effect

From the side of the central nervous system and peripheral nervous system: drowsiness, fatigue, tremors, convulsions, headache, dizziness, ataxia, weakness. From the side of the organ of vision: acute glaucoma, violation of accommodation. From the urinary system: acute urinary retention. From the side of the cardiovascular system: tachycardia, decreased blood pressure. From the digestive system: dry mouth, constipation, increased activity of transaminases. Others: bronchospasm, allergic reactions, excessive sweating.

Application during pregnancy and lactation

Hydroxyzine is contraindicated for use during pregnancy, during childbirth. Lactation (breastfeeding) is a contraindication to use.

Application for violations of liver function

Use with caution in patients with hepatic impairment.

Application for impaired renal function

Use with caution in patients with renal insufficiency.

special instructions

Use with caution in patients with renal failure, myasthenia gravis, difficulty urinating, constipation, dementia, a tendency to seizures, arrhythmias or taking antiarrhythmic drugs, liver failure. With subcutaneous administration of hydroxyzine, tissue damage is possible, with intravenous administration - hemolysis. If it is necessary to conduct allergological tests, taking hydroxyzine should be discontinued 5 days before the study. Influence on the ability to drive vehicles and use mechanisms

During the period of therapy, it is necessary to refrain from engaging in potentially hazardous activities that require increased attention and rapid psychomotor reactions.

Drug interactions

With the simultaneous use of hydroxyzine enhances the effects of analgesics, anxiolytics, barbiturates, ethanol.