hydroxyprogesterone kaproat | Oxyprogesterone solution in olive oil 12.5%, 1 ml, 10 pcs.
Special Price
$33.95
Regular Price
$42.00
In stock
SKU
BID494623
Release form
Solution for intramuscular injection
Solution for intramuscular injection
Release form
Solution for intramuscular injection
Packing
10 pcs.
Pharmacological action
Oxyprogesterone - an analogue of the corpus luteum hormone (progesterone). Chemically different from progesterone in that in position 17 it contains a caproic acid residue. Being an ester of hydroxyprogesterone, it metabolizes more slowly than progesterone (it has a longer effect). After a single IM injection of the oil solution, its effect lasts from 7 to 14 days. Biologically similar to progesterone. Contacting the receptors on the surface of the cells of target organs, it penetrates into the nucleus, where, by activating DNA, it stimulates RNA synthesis. It promotes the transition of the uterine mucosa from the proliferation phase caused by the follicular hormone to the secretory one, and after fertilization creates the necessary conditions for implantation and development of a fertilized egg. It reduces the excitability and contractility of the muscles of the uterus and fallopian tubes, stimulates the development of terminal elements of the mammary gland.
Pharmacokinetics
Quickly and almost completely absorbed after intramuscular administration.
Metabolized in the liver to form conjugates with glucuronic and sulfuric acids.
T1 / 2 is 5 min. It is excreted by the kidneys - 50-60%, with bile - more than 10%. The number of metabolites excreted by the kidneys varies depending on the phase of the corpus luteum
Indications
Conditions associated with insufficiency of the corpus luteum: a threatening and beginning miscarriage (prevention and treatment), amenorrhea (primary and secondary), dysfunctional uterine bleeding.
Contraindications
hepatitis
liver failure
breast and genital cancer
prone to thrombosis
children under 15 years of age,
second half of pregnancy
hypersensitivity to the components of the drug.
Caution: for diseases of the cardiovascular system, arterial hypertension, chronic renal failure, diabetes mellitus, bronchial asthma, epilepsy, migraine, depression of hyperlipoproteinemia.
Treatment is often combined with the administration of estrogen drugs or is carried out immediately after estrogen therapy.
Use during pregnancy and lactation
The drug is not used during pregnancy. In the event of pregnancy on the background of the use of the drug, it is necessary to immediately interrupt the treatment of data on the need to terminate the pregnancy. The drug is contraindicated in the second half of pregnancy and during breastfeeding.
Special instructions
If crystals precipitate or crystallize the entire contents of the ampoule, the ampoule should be heated in a boiling water bath with shaking. If the crystals disappear and the solution becomes transparent, and when cooled to 36-38 РC, the crystals do not drop out again, the solution is suitable for use.
The prescription of the drug should be done only by the attending physician, under his supervision after an accurate diagnosis.
In the treatment of amenorrhea in children, verification of the diagnosis of amenorrhea is primarily necessary.
Treatment before adolescence should be aimed at stimulating growth. After 15-17 years, you can carry out replacement therapy with estrogens and gestagens, which causes cyclic uterine bleeding!
Effect on the ability to drive vehicles,
mechanisms Caution should be exercised when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions, since the drug can cause side effects that can affect these abilities.
Composition of
1 ampoule with 1 ml of injection solution in peach or olive oil contains 125 mg of hydroxyprogesterone capronate (12 mg).
Dosage and Administration
Intramuscularly.
In order to prevent and treat a threatening and started miscarriage, 0.125-0.25 g (1-2 ml of 12.5% solution) is administered once a week. Apply only in the first half of pregnancy.
In case of amenorrhea (primary, secondary), they are prescribed immediately after stopping the use of estrogen drugs at 0.25 g, once, or in 2 injections.
For the treatment of dysfunctional uterine bleeding, the drug is less convenient than progesterone, because its effect occurs slowly, but it can be used to normalize the cycle: 0.0625-0.125 g (0.5-1 ml of 12.5% solution) on the 20-22 day of the cycle.
Side effects of
From the nervous system: drowsiness, headache, depression, apathy, dysphoria.
From the digestive system: cholestatic hepatitis, nausea, vomiting, decreased appetite, calculous cholecystitis.
From the genitourinary system: decreased libido, shortened menstrual cycle, intermediate bleeding.
On the part of the sensory organs: impaired vision.
From the CCC side: increased blood pressure, edema, thromboembolism (including pulmonary artery and cerebral vessels), thrombophlebitis, retinal vein thrombosis.
From the endocrine system: galactorrhea, alopecia, weight gain, increase, pain and tension of the mammary glands hirsutism. Allergic reactions.
Local reactions: pain at the injection site.
Drug interactions
Weakens the effects of drugs that stimulate the reduction of myometrium (oxytocin), anabolic steroids (nandrolone), pituitary gonadotropin hormones.
Enhances the action of diuretics, antihypertensive drugs, immunosuppressants, bromocriptine.
Reduces the effectiveness of anticoagulants.
The progestational activity of the drug is reduced by microsomal oxidation inducers (barbiturates, hydantoins, rifshpitsin, etc.).
Overdose
Symptoms: central nervous system depression, drowsiness, tachycardia high blood pressure, weakness, sweating.
Treatment: discontinuation of treatment until symptoms disappear, followed by lower doses. If necessary, conduct symptomatic treatment.
Storage Conditions
Store in a dark place at 5 to 25 РC. Keep out of reach of children.
shelf life
5 years
Deystvuyushtee substance
Gidroksiprogesterona caproate
otpuska IZ
pharmacy prescription
Dosage form
injection for injection
Possible product names
OXYPROGESTER CAPR 12.5% 1ML N10 AMP
Oxyprogesterone solution in olive oil 12.5%, 1 ml, 10 pcs.
OXYPROGESTERON CAPRONATE 12.5% 1ML. RR D / IN. No. 10 AMP.
Oxyprogesterone capronate 125mg / ml solution for i.v. oil 1ml amp. X10 B M
OXYPROGESTERON CAPRONATE AMP. 12.5% No. 10
Dalchimpharm, Russia
Solution for intramuscular injection
Packing
10 pcs.
Pharmacological action
Oxyprogesterone - an analogue of the corpus luteum hormone (progesterone). Chemically different from progesterone in that in position 17 it contains a caproic acid residue. Being an ester of hydroxyprogesterone, it metabolizes more slowly than progesterone (it has a longer effect). After a single IM injection of the oil solution, its effect lasts from 7 to 14 days. Biologically similar to progesterone. Contacting the receptors on the surface of the cells of target organs, it penetrates into the nucleus, where, by activating DNA, it stimulates RNA synthesis. It promotes the transition of the uterine mucosa from the proliferation phase caused by the follicular hormone to the secretory one, and after fertilization creates the necessary conditions for implantation and development of a fertilized egg. It reduces the excitability and contractility of the muscles of the uterus and fallopian tubes, stimulates the development of terminal elements of the mammary gland.
Pharmacokinetics
Quickly and almost completely absorbed after intramuscular administration.
Metabolized in the liver to form conjugates with glucuronic and sulfuric acids.
T1 / 2 is 5 min. It is excreted by the kidneys - 50-60%, with bile - more than 10%. The number of metabolites excreted by the kidneys varies depending on the phase of the corpus luteum
Indications
Conditions associated with insufficiency of the corpus luteum: a threatening and beginning miscarriage (prevention and treatment), amenorrhea (primary and secondary), dysfunctional uterine bleeding.
Contraindications
hepatitis
liver failure
breast and genital cancer
prone to thrombosis
children under 15 years of age,
second half of pregnancy
hypersensitivity to the components of the drug.
Caution: for diseases of the cardiovascular system, arterial hypertension, chronic renal failure, diabetes mellitus, bronchial asthma, epilepsy, migraine, depression of hyperlipoproteinemia.
Treatment is often combined with the administration of estrogen drugs or is carried out immediately after estrogen therapy.
Use during pregnancy and lactation
The drug is not used during pregnancy. In the event of pregnancy on the background of the use of the drug, it is necessary to immediately interrupt the treatment of data on the need to terminate the pregnancy. The drug is contraindicated in the second half of pregnancy and during breastfeeding.
Special instructions
If crystals precipitate or crystallize the entire contents of the ampoule, the ampoule should be heated in a boiling water bath with shaking. If the crystals disappear and the solution becomes transparent, and when cooled to 36-38 РC, the crystals do not drop out again, the solution is suitable for use.
The prescription of the drug should be done only by the attending physician, under his supervision after an accurate diagnosis.
In the treatment of amenorrhea in children, verification of the diagnosis of amenorrhea is primarily necessary.
Treatment before adolescence should be aimed at stimulating growth. After 15-17 years, you can carry out replacement therapy with estrogens and gestagens, which causes cyclic uterine bleeding!
Effect on the ability to drive vehicles,
mechanisms Caution should be exercised when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions, since the drug can cause side effects that can affect these abilities.
Composition of
1 ampoule with 1 ml of injection solution in peach or olive oil contains 125 mg of hydroxyprogesterone capronate (12 mg).
Dosage and Administration
Intramuscularly.
In order to prevent and treat a threatening and started miscarriage, 0.125-0.25 g (1-2 ml of 12.5% solution) is administered once a week. Apply only in the first half of pregnancy.
In case of amenorrhea (primary, secondary), they are prescribed immediately after stopping the use of estrogen drugs at 0.25 g, once, or in 2 injections.
For the treatment of dysfunctional uterine bleeding, the drug is less convenient than progesterone, because its effect occurs slowly, but it can be used to normalize the cycle: 0.0625-0.125 g (0.5-1 ml of 12.5% solution) on the 20-22 day of the cycle.
Side effects of
From the nervous system: drowsiness, headache, depression, apathy, dysphoria.
From the digestive system: cholestatic hepatitis, nausea, vomiting, decreased appetite, calculous cholecystitis.
From the genitourinary system: decreased libido, shortened menstrual cycle, intermediate bleeding.
On the part of the sensory organs: impaired vision.
From the CCC side: increased blood pressure, edema, thromboembolism (including pulmonary artery and cerebral vessels), thrombophlebitis, retinal vein thrombosis.
From the endocrine system: galactorrhea, alopecia, weight gain, increase, pain and tension of the mammary glands hirsutism. Allergic reactions.
Local reactions: pain at the injection site.
Drug interactions
Weakens the effects of drugs that stimulate the reduction of myometrium (oxytocin), anabolic steroids (nandrolone), pituitary gonadotropin hormones.
Enhances the action of diuretics, antihypertensive drugs, immunosuppressants, bromocriptine.
Reduces the effectiveness of anticoagulants.
The progestational activity of the drug is reduced by microsomal oxidation inducers (barbiturates, hydantoins, rifshpitsin, etc.).
Overdose
Symptoms: central nervous system depression, drowsiness, tachycardia high blood pressure, weakness, sweating.
Treatment: discontinuation of treatment until symptoms disappear, followed by lower doses. If necessary, conduct symptomatic treatment.
Storage Conditions
Store in a dark place at 5 to 25 РC. Keep out of reach of children.
shelf life
5 years
Deystvuyushtee substance
Gidroksiprogesterona caproate
otpuska IZ
pharmacy prescription
Dosage form
injection for injection
Possible product names
OXYPROGESTER CAPR 12.5% 1ML N10 AMP
Oxyprogesterone solution in olive oil 12.5%, 1 ml, 10 pcs.
OXYPROGESTERON CAPRONATE 12.5% 1ML. RR D / IN. No. 10 AMP.
Oxyprogesterone capronate 125mg / ml solution for i.v. oil 1ml amp. X10 B M
OXYPROGESTERON CAPRONATE AMP. 12.5% No. 10
Dalchimpharm, Russia
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