Hydroksykarbamyd | Hydrea capsules 500 mg, 20 pcs.
Special Price
$16.49
Regular Price
$25.00
In stock
SKU
BID467889
Release form
Capsules.
packaging 20 pcs
Pharmacological action
Pharmacodynamics
Antitumor agent. The proposed mechanism of action is inhibition of DNA synthesis. It does not affect the synthesis of protein and RNA.
Pharmacokinetics
After oral administration, it is well absorbed from the gastrointestinal tract. Penetrates through the BBB. Metabolized in the liver. It is excreted mainly by the kidneys (80%). T1 / 2 - 3-4 hours
Indications
Chronic myelogenous leukemia
melanoma
ovarian cancer cervical cancer
choriocarcinoma of the uterus
tumor of the head and neck
brain tumor
erythremia.
Contraindications
Leukopenia less than 2500 / μl
thrombocytopenia less than 100,000 / μl
severe anemia
pregnancy
hypersensitivity to hydroxycarbamide.
Use during pregnancy and lactation
Hydroxycarbamide is contraindicated in pregnancy. If necessary, use during lactation should stop breastfeeding.
Women of childbearing age receiving hydroxycarbamide therapy should use reliable methods of contraception.
In experimental studies, the teratogenic and embryotoxic effects of hydroxycarbamide were established.
Composition
1 capsule contains:
Active substances: hydroxycarbamide 500 mg.
Dosage and administration
Installed individually, depending on the indications and stage of the disease, the state of the hematopoietic system, anti-tumor therapy regimen.
Side effects
From the hematopoietic system: leukopenia, thrombocytopenia, anemia.
From the digestive system: stomatitis, anorexia, nausea, vomiting, diarrhea, constipation rarely - impaired liver function.
From the side of the central nervous system: feeling tired, headache, drowsiness, dizziness, hallucinations, cramps.
From the respiratory system: in some cases - diffuse pulmonary infiltrates, accompanied by fever and shortness of breath.
From the urinary system: difficulty urinating rarely - impaired renal function.
Dermatological reactions: alopecia, maculopapular rash, erythema.
Other: fever, chills.
Drug Interaction
Increased myelodepression in the case of prior cytotoxic therapy.
Overdose
Treatment symptomatic, because no specific antidote is dialyzed.
Storage conditions
Store in a dark place at a temperature of 15–25 РC.
Keep out of the reach of children.
Expiration
5 years.
Deystvuyuschee substances
Hydroksykarbamyd
Capsule Dosage Form A dosage form
capsules
Bristol-Myers Squibb, US
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