Horulon 5 vials of 5 ml, 1500 IU each (with solvent)

DESCRIPTION

Horulon is a drug for the treatment of gynecological diseases and increasing the reproductive function of farm animals and dogs. Dosage form: lyophilized powder with a solvent. In appearance, the drug is a white powder, the solvent is a clear, colorless liquid.

COMPOSITION

The drug contains in 1 vial as an active ingredient 1500ME human chorionic gonadotropin (hCG), as excipients: mannitol, sodium hydrogen phosphate dihydrate, sodium dihydrogen phosphate dihydrate, water for injection. Solvent in 1 ml contains: sodium hydrogen phosphate dihydrate, sodium dihydrogen phosphate dihydrate, water for injection.

PHARMACOLOGICAL PROPERTIES

Pharmacotherapeutic group of the drug: hormones and their antagonists.

Chorionic gonadotropin (hCG) acts on the ovary in a similar way to luteinizing hormone (LH) and binds to LH receptors. Chorulone in females stimulates the function of the interstitial cells of the ovaries, which ensure the maturation of the follicle, induces ovulation, promotes luteinization of granulosa cells and maintains the activity of the corpus luteum, and also increases the level of progesterone in the blood. In males, it stimulates the production of testosterone.

With the injection of the drug, due to the high bioavailability of gonadotropic hormone (hCG), its maximum concentration in the blood plasma of animals is reached 8 hours after intramuscular administration.

The half-life from the body is 10 hours in cows and 27 hours in pigs.

Horulon, according to the degree of impact on the body, belongs to low-hazard substances (hazard class 4 according to GOST 12.1.007-76).

There is no information about the features of the use of Horulon with drugs of other pharmacological groups.

INDICATIONS

Horulon is used to treat gynecological diseases, stimulate reproductive function and synchronize ovulation, treat follicular cysts, maintain the functioning of the corpus luteum and progesterone levels in the blood, as well as treat nymphomania in female farm animals. In males, Horulon stimulates testosterone production and thus influences the development and maintenance of primary and secondary sexual characteristics.

APPLICATION

Before use, the contents of the vial are dissolved at the rate of 1500 ME per 5 ml of solvent. The resulting solution is administered intramuscularly or intravenously. The dose and route of administration depend on the type of animal and the indication for use.

Kind of animal Indications for use Dosage Method of introduction

Cows, heifers to stimulate ovulation, increase fertility 1500ME, once, 2 - 3 hours before or simultaneously with insemination intramuscularly or intravenously

prevention of embryonic mortality 1500ME, once 6 days after insemination intramuscularly

treatment of follicular ovarian cysts, anestrus, prolonged hunting, nymphomania 3000ME, single use intravenously

Mares to stimulate ovulation (follicles> 3.5cm) 1500-3000ME, once, 24 hours before insemination intramuscularly or intravenously

Anestrus (follicles> 2cm) 1500-3000ME, once, 24 hours before or at the time of insemination; if necessary, re-enter after 48 hours intramuscularly or intravenously

Sows, gilts stimulation and synchronization of ovulation 500ME, once, 24 hours before or at the time of mating intramuscularly

Bitches anestrus 500ME, once, on the first day of estrus after pretreatment with Folligon intramuscularly or intravenously

delayed ovulation, prolonged heat 100-800ME, once a day, repeat the treatment until the discharge from the vagina disappears (but not more than 5-8 days) intramuscularly

Males cryptorchidism 100-500ME, 2 times a week, for 6 weeks intramuscularly

lack of libido 100-500ME, once, 6-12 hours before mating intramuscularly

When using Horulon, in rare cases, anaphylactic-type reactions are possible. In these cases, the immediate introduction of adrenergic agonists (1: 1000) intravenously or intramuscularly is recommended.

The use of Horulon is allowed during the first 2 weeks of pregnancy, as well as in lactating animals.

SPECIAL INSTRUCTIONS

Violations of the timing of the use of the drug should be avoided as this can lead to a decrease in the therapeutic effectiveness of treatment. If the next injection is missed, it is necessary to apply the drug as soon as possible in the same dose.

Meat, slaughter products after using Horulon can be used for food purposes without restrictions.

CONTRAINDICATIONS

It is forbidden to use Horulon in case of increased individual sensitivity of the animal to the components of the drug.

It is forbidden to use Horulon during pregnancy more than 2 weeks.

SIDE EFFECTS

As a rule, there are no side effects and complications when using Horulon in accordance with these instructions for use.

PRECAUTIONS

When working with Horulon, you should follow the general rules of personal hygiene and safety measures provided for when working with medicines. At the end of work, hands should be washed with warm water and soap. Empty packages from under the medicinal product must not be used for domestic purposes, they must be disposed of with household waste.

FIRST AID MEASURES

In case of accidental contact of the drug with the skin or mucous membranes, they should be rinsed with plenty of clean water.People with hypersensitivity to the components of the drug should avoid direct contact with Horulon. In case of allergic reactions or accidental ingestion of the drug into the human body, you should immediately contact a medical institution (you should have instructions for use of the drug or a label with you).

STORAGE

Chorulon is stored in closed manufacturer's packaging, separately from food and feed, at a temperature of 5 В° C to 25 В° C, after dissolution - at a temperature of 2 В° C to 8 В° C. The shelf life of Horulon, subject to storage and transportation conditions, is 3 years from the date of production. Once dissolved, the medicinal product can be used within 24 hours. It is forbidden to use Horulon after the expiration date.

PACKING

The drug is packaged in 5 ml glass bottles of appropriate capacity. The solvent is released packaged in 5 ml glass bottles of appropriate capacity. The package contains 5 bottles with the drug and 5 bottles with a solvent.

Specifications

KolVUP

1

Manufacturer

Intervet

Temperature regime

from +2 to +25

Teaser

drug for the treatment of gynecological diseases and increasing the reproductive function of farm animals and dogs