Hexoral aerosol 0.2%, 40 ml

As a symptomatic remedy.

Х Symptomatic treatment for inflammatory and infectious diseases of the oral cavity and larynx:

- tonsillitis, tonsillitis (including Plaut-Vincent tonsillitis, tonsillitis of the lateral ridges), pharyngitis, gingivitis, stomatitis, glossitis, periodontal disease;

- fungal diseases;

Х prevention of infectious complications before and after surgery on the oral cavity and larynx and in trauma, including prevention of infection of the alveoli after tooth extraction;

Х oral hygiene, including to eliminate bad breath.

Locally. Children from 3 to 6 years old: the use of the drug is possible after consultation with a medical professional. Adults and children over 6 years old: treat the affected areas while holding their breath, 1 injection for 1-2 seconds, 2 times a day. During the administration of the drug, a delay is required breathing, since inhalation of the drug can provoke laryngospasm. Hexetidine adheres to the mucous membrane and therefore gives a lasting effect. In this regard, the drug should be used after meals.

Composition:

100 ml of the preparation contains:

active ingredient - hexetidine - 0.200 g;

excipients: polysorbate 80 - 1.400 g, citric acid monohydrate - 0.070 g, sodium saccharinate - 0.040 g, levomenthol - 0.070 g, eucalyptus leaf oil - 0.0011 g, sodium calcium edetate - 0.100 g, ethanol 96% - 4.333 g , sodium hydroxide - qs up to pH 5.5 ± 0.2, purified water - qs up to 100 ml, nitrogen - qs up to 5 bar.

Х Hypersensitivity to any component of the drug;

Х erosive-desquamous lesions of the oral mucosa;

Х children under 3 years old.

Pharmacodynamics

The antimicrobial effect of the drug 'HexoralЃ' is associated with the suppression of oxidative reactions of bacterial metabolism (thiamine antagonist). The drug has a wide spectrum of antibacterial and antifungal action, in particular against gram-positive bacteria and fungi of the genus Candida, however, HexoralЃ can also have an effect in the treatment of infections caused, for example, by Pseudomonas aeruginosa or Proteus spp. At a concentration of 100 mg / ml, the drug suppresses most bacterial strains. Resilience development was not observed. Hexetidine has a weak anesthetic effect on the mucous membrane. The drug has an antiviral effect against influenza A viruses, respiratory syncytial virus (RS virus), herpes simplex virus type 1, affecting the respiratory tract.

Pharmacokinetics

Hexetidine adheres very well to the mucous membrane and is practically not absorbed. After a single application of the active substance, its traces are found on the gingival mucosa for 65 hours. In dental plaque, active concentrations remain for 10-14 hours after application.

Application of pr and pregnancy and during breastfeeding

There is no information about any undesirable effects of the drug 'HexoralЃ' during pregnancy and during breastfeeding. However, before prescribing HexoralЃ to pregnant or lactating women, the doctor should carefully weigh the benefits and risks of treatment, given the lack of sufficient data on the penetration of the drug through the placenta and into breast milk.

Side effect

Immune system disorders.

Very rare: hypersensitivity reactions (including urticaria), angioedema.

Nervous system disorders.

Very rare: ageusia, dysgeusia.

Disturbances from the respiratory system, chest and mediastinal organs.

Very rare: cough, shortness of breath due to the appearance of a hypersensitivity reaction, laryngospasm.

Disorders from the gastrointestinal tract.

Very rare: dry mouth, dysphagia, nausea, enlarged salivary glands, vomiting.

General disorders and disorders at the injection site.

Very rare: reactions at the site of application (including irritation of the oral mucosa and pharynx, burning sensation, paresthesia of the oral cavity, discoloration of the tongue, discoloration of the teeth, inflammation, blistering and ulceration). If any of the side effects indicated in the instructions are aggravated or you notice other side effects, it is recommended to consult a doctor.

Overdose

It is unlikely that hexetidine can have toxic effects when used according to the instructions for use of the medicinal product. Swallowing a large amount of a preparation containing ethanol may lead to signs / symptoms of alcohol intoxication. In any case of overdose, consult your doctor immediately. Treatment is symptomatic, as with alcohol intoxication. Gastric lavage is necessary within 2 hours after swallowing the excess dose.

Interaction with other medicinal products

No data available.

special instructions

There are no special prescriptions. During the administration of the drug, a breath hold is required. Children can use the drug from an age when there is no danger of uncontrolled swallowing or when they do not resist a foreign object (spray nozzle) in their mouth when using the aerosol and are able to hold their breath when injecting the drug. The ethanol content in the preparation is 5.15%. One dose of the drug contains 20.3 mg of ethanol (in terms of absolute alcohol). The contents of the aerosol can are under pressure. Do not open, puncture or incinerate, even when empty. If a medicinal product has become unusable or the expiration date has expired, do not pour it into wastewater or throw it out into the street. Place the medicine in a bag and put it in the trash can.These measures will help protect the environment.