Helmicide granulate 1kg

DESCRIPTION

Helmicide granules (Helmicid granules) - a drug for deworming cattle and small ruminants. In appearance, the drug is gray granules.

COMPOSITION

The medicinal preparation as active ingredient contains in 1 g of granules: albendazole - 200 mg and oxyclosanide - 70 mg, as well as auxiliary substances: polyvinylpyrrolidone, potato starch and lactose.

PHARMACOLOGICAL PROPERTIES

Helmicide granules belong to the group of combined anthelmintic drugs.

The combination of albendazole and oxyclosanide, which are part of the drug, provides a wide spectrum of anthelmintic action of granules against nematodes, cestodes and trematodes.

Albendazole is effective in mono- and polyinvasions caused by imago and larvae of nematodes and cestodes, as well as imago of trematodes. Possessing an ovocidal effect, it reduces the infection of pastures with helminth eggs.

The mechanism of action of albendazole is to selectively suppress beta-tubulin polymerization, which leads to the destruction of cytoplasmic microtubules of cells of the intestinal tract of the helminth; changing the course of biochemical processes, albendazole inhibits glucose utilization and inhibits the synthesis of ATP, blocks the movement of secretory granules and other organelles in the muscle cells of helminths, causing their death.

Oxyclozanide has a pronounced trematodocidal effect on the larval and mature phases of development of the trematodes Fasciola spp., Paramphistomum spp. and Dicrocoelium lanceatum parasitizing ruminants.

The mechanism of action of oxyclozanide is to disrupt the phosphorylation processes in helminths, to reduce the activity of fumarate reductase and succinate dehydrogenase, which leads to paralysis and death of trematodes.

When administered orally, albendazole and oxyclosanide are rapidly absorbed in the gastrointestinal tract and penetrate into organs and tissues; from the body of animals are excreted mainly in the urine and partly with feces in unchanged form and in the form of metabolites.

Helmicide granules, according to the degree of impact on the body, are classified as low-hazard substances (hazard class 4 according to GOST 12.1.007-76), in recommended doses they are well tolerated by animals.

DOSAGE AND APPLICATION

Helmicide granules are used for deworming cattle and small ruminants with trematoses (acute and chronic fascioliasis, dicroceliosis, paramphistosis), nematodoses of the gastrointestinal tract (hemonhoses, bunostomiasis, esophagostomiasis, trimesteritis, ostertilozymiasis, cobalthosis, chylosistosis, ), nematodes of the lungs (dictyocaulosis, protostrongylosis, mulleriosis, cystocaulosis) and cestodosis (moniesiasis, avitellinosis, tizanesiosis).

Helmicide granules are applied to animals once, orally (inside), individually or in a group way in a mixture with concentrated feed, in the following doses (g of granules per animal weight):

cattle with fascioliasis, dicroceliosis, paraphistomiasis and ostertagiosis - 7, 5 g per 100 kg; with cestodoses and nematodes (excluding ostertagiosis) - 3.75 g per 100 kg;

sheep and goats with fascioliasis, dicroceliosis, paramphistomiasis and protostrongylidosis - 7.5 g per 100 kg; with cestodoses and nematodes (excluding protostrongylidosis) - 2.5 g per 100 kg.

With the group method of application, the amount of the drug, calculated for a group of no more than 10 heads of cattle and no more than 100 heads of sheep and goats, is mixed with concentrated feed at the rate of: for cattle 0.5-1.0 kg, for sheep and goats - 150-200 g of feed per animal. The resulting medicinal mixture is poured into feeders, providing the animals with free access to them. In case of group deworming, special attention should be paid to thorough mixing of the drug with feed and to eating it by all animals.

A special diet and the use of laxatives before deworming are not required.

Before mass deworming, each batch of the drug is preliminarily tested on a small group of animals (5-10 animals). In the absence of complications, the entire livestock is processed within 3 days.

SPECIAL INSTRUCTIONS

In case of an overdose of the drug, the animal may experience anorexia, impaired motility of the gastrointestinal tract, motor discoordination, and lethargy. In these cases, general measures are taken to remove the drug from the body, and symptomatic treatment is prescribed.

The peculiarities of the action at the first use of the drug and at its cancellation were not revealed.

It is forbidden to use the drug during the breeding period, pregnant sheep, goats and pregnant cows in the first half of pregnancy. The possibility of using the drug for lactating females and newborn young animals is determined by the attending veterinarian based on an assessment of the ratio of benefits to the possible risk of its use.

Violations of the recommended timing for deworming animals should be avoided, as this can lead to a decrease in therapeutic efficacy.

Slaughter of animals for meat is allowed no earlier than 21 days after deworming. In case of forced slaughter of a previously established period, the meat can be used as feed for fur animals.

Milk of dairy animals must not be used for food purposes within 4 days after deworming. The milk obtained earlier than the established period can be used after boiling in animal feed.

CONTRAINDICATIONS

A contraindication to the use of Helmicide granules is the increased individual sensitivity of the animal to the components of the drug. The drug should not be used by patients with infectious diseases and malnourished animals.

SIDE EFFECTS

When using Helmicide granules in accordance with this instruction, side effects and complications, as a rule, are not observed. With increased individual sensitivity to the components of the drug, individual reactions are possible (depression, hypersalivation, diarrhea), which spontaneously pass and do not require the use of drugs.

SHELF LIFE AND STORAGE

The shelf life of the medicinal product, subject to storage conditions, is 3 years from the date of production. Do not use the drug after the expiration date.

Store the granules in the manufacturer's closed packaging, in a dry place protected from direct sunlight, separately from food and feed, at a temperature from 0 C to 25 В° C.

PACKAGING

The drug is produced in packs of 1 kg in bags made of paper and combined materials and in polymer cans sealed with stretched polymer lids. Each consumer package is supplied with instructions for use and a 5 g measuring spoon with divisions.

Specifications

KolVUP

8

Manufacturer

Agrovetzashita

Temperature regime

from 0 to +25

Teaser

for deworming cattle and small ruminants