Grammidin NEO with anesthetic tablets, no. 18

Infectious and inflammatory diseases of the mouth and throat: tonsillitis, pharyngitis, tonsillitis, periodontal disease, gingivitis, stomatitis.

Inside, after eating, by absorption in the mouth, without chewing.

Immediately after using the drug, you should refrain from eating and drinking for 1-2 hours.

Dosage for adults and children over 12 years old: 1 tab. 3-4 times a day.

Dosage for children from 4 to 12 years old: 1 tab. 1-2 times a day.

In the absence of a therapeutic effect within 7 days of taking the drug, it is recommended to consult a doctor.

Lozenges

1 tablet contains active substances:

gramicidin C dihydrochloride 0.003 g (in terms of gramicidin C)

oxybuprocaine hydrochloride 0.0002 g

cetylpyridinium chloride monohydrate 0.001 g (in terms of cetylpyridinium chloride)

excipients: colloidal silicon dioxide (AerosilЃ 200); talc; acesulfame potassium; mint flavor; sorbitol (NeosorbЃ), magnesium stearate

-Increased sensitivity to the components that make up the drug;

-pregnancy (I trimester);

- age up to 4 years.

Pharmacodynamics

Combined drug for the treatment of infectious and inflammatory diseases of the throat and oral cavity. The preparation contains the antimicrobial agent gramicidin C, local anesthetic (analgesic) agent - oxybuprocaine and antiseptic agent - cetylpyridinium chloride.

The mechanism of action of gramicidin C is associated with an increase in the permeability of the cytoplasmic membrane of the microbial cell, which disrupts its stability and causes cell death. Gramicidin C has a pronounced antimicrobial effect against causative agents of infectious diseases of the oral cavity and pharynx.

The anesthetic oxybuprocaine has a local analgesic effect on the mucous membrane of the mouth and throat. It causes a reversible blockade of the propagation and conduction of nerve impulses through the axons of nerve cells.

Cetylpyridinium chloride is an antiseptic. Suppresses the growth and reproduction of pathogens of infectious diseases of the oral cavity.

The drug has an analgesic effect, reduces inflammation, has an antimicrobial effect, softens discomfort in the throat, facilitates swallowing, and when absorbed, causes hypersalivation, which contributes to the mechanical cleansing of the oral cavity and pharynx from microorganisms.

Pharmokinetics

The drug has a local effect and is practically not absorbed in the gastrointestinal tract, which determines the almost complete absence of systemic effects.

Side effects

In some cases, allergic reactions to the components of the drug, temporary loss of tongue sensitivity are possible.

Drug interactions

GrammidinЃ with neo anesthetic enhances the effects of other local and systemic antimicrobial agents.