Genferon suppositories 500000ME, No. 10

As part of complex therapy for infectious and inflammatory diseases of the urogenital tract:

• genital herpes; x

• lamidiosis;

• ureaplasmosis;

• mycoplasmosis;

• recurrent vaginal candidiasis;

• gardnerellosis;

• trichomoniasis;

• human papillomavirus infections;

• bacterial vaginosis;

• erosion of the cervix;

• cervicitis;

• vulvovaginitis;

• bartholinitis;

• adnexitis;

• prostatitis;

• urethritis;

• balanitis;

• balanoposthitis.

For infectious and inflammatory diseases of the urogenital tract in women, the drug is prescribed intravaginally, 1 supp. (250 thousand or 500 thousand IU, depending on the severity of the disease) 2 times / day for 10 days. In chronic diseases, the drug is prescribed 3 times a week (every other day), 1 supp. within 1-3 months.

For infectious and inflammatory diseases of the urogenital tract in men, the drug is prescribed rectally, 1 supp. (500 thousand-1 million IU, depending on the severity of the disease) 2 times / day for 10 days.

Vaginal or rectal suppositories

1 supp.

active substances:

interferon alpha-2 human recombinant 250,000/500000/1000000 IU

taurine 0.01 g

benzocaine 0.055 g

excipients: solid fat; dextran 60,000; macrogol 1500; twin 80; emulsifier T2; sodium hydrocitrate; citric acid; purified water.

Individual intolerance to interferon and other substances that make up the drug.

pharmachologic effect

Combined drug, the action of which is due to the components that make up its composition. Provides local and systemic immunomodulatory effects.

Interferon alpha-2 has antiviral, antimicrobial and immunomodulatory effects. Under the influence of interferon alpha-2, the activity of natural killers, T-helpers, phagocytes increases, as well as the intensity of differentiation of B-lymphocytes. Activation of leukocytes contained in all layers of the mucous membrane ensures their active participation in the elimination of primary pathological foci and restoration of the production of secretory immunoglobulin A.

Interferon alpha-2 also directly inhibits the replication and transcription of viruses, chlamydia.

Taurine has membrane and hepatoprotective, antioxidant and anti-inflammatory properties, enhances tissue regeneration.

Benzocaine is a local anesthetic. Reduces the permeability of cell membranes for sodium ions, displaces calcium ions from receptors located on the inner surface of the membrane, and blocks the conduction of nerve impulses. Prevents the emergence of pain impulses in the endings of the sensory nerves and their conduction along the nerve fibers.

Pharmacokinetics

With vaginal or rectal administration, interferon alpha-2 is absorbed through the mucous membrane, enters the surrounding tissues, into the lymphatic system, providing a systemic effect. Also, due to partial fixation on the cells of the mucous membrane, it has a local effect.

A decrease in the level of serum interferon 12 hours after administration of the drug necessitates its repeated administration.

Side effect

Allergic reactions: skin rash, itching. These phenomena are reversible and disappear 72 hours after dose reduction or drug withdrawal.

With the introduction of the drug at a dose of 10 million IU / day, the risk of developing the following side effects increases.

From the side of the central nervous system: headache.

From the hematopoietic system: leukopenia, thrombocytopenia.

Others: fever, increased sweating, fatigue, myalgia, loss of appetite, arthralgia.

Application during pregnancy and lactation

If it is necessary to use the drug in the II and III trimesters of pregnancy, the intended benefit to the mother and the potential risk to the fetus should be correlated.

special instructions

The drug should be used with caution in patients with allergic and autoimmune diseases in the acute stage.

Overdose

To date, no cases of overdose of Genferon have been reported.

Drug interactions

When combined with antibiotics and other antimicrobial drugs used to treat urogenital infections, the effectiveness of Genferon increases.

When used simultaneously with vitamins E and C, the effect of interferon is enhanced.

When combined with NSAIDs and anticholinesterase drugs, the effect of benzocaine is potentiated.

When used together, the antibacterial activity of sulfonamides decreases (due to the action of benzocaine)