Gel for external use Dr. Reddy's Nise, 1%, 50 g
Dosage:
1% x 100g
1% x 20g
1% x 50g
Scope of the medicinal product
General
Release form
Gel
Manufacturer country
India
Package quantity, pcs
one
Scope of application
Orthopedics
Release form, composition and packaging
Gel for external use 1% light yellow or yellow, transparent, free from foreign particles.
1 g
nimesulide
10 mg
N-methyl-2-pyrrolidone - 250 mg, propylene glycol - 100 mg, macrogol - 315.5 mg, isopropanol - 100 mg, purified water - 200 mg, carbomer 940 - 20 mg, butylhydroxyanisole - 0.2 mg, thiomersal - 0.1 mg, potassium dihydrogen phosphate - 0.2 mg, flavor (Narcissus-938) - 4 mg.
20 g - tubes made of laminated aluminum (1) - cardboard packs.
50 g - tubes made of laminated aluminum (1) - packs of cardboard. Pharmacological action of new generation NSAIDs from the sulfonanilide class.
It has a local anesthetic and anti-inflammatory effect.
Nimesulide is a selective competitive reversible inhibitor of COX-2 (endoperoxide prostaglandin H2 synthetase). Reduces the concentration of short-lived prostaglandin H2, a substrate for kinin-stimulated synthesis of prostaglandin E2, in the focus of inflammation and in the ascending pathways of pain impulses in the spinal cord. A decrease in the concentration of prostaglandin E2 (a mediator of inflammation and pain) reduces the activation of prostanoid receptors of the EP type, which manifests itself in analgesic and anti-inflammatory effects.
When applied topically, it causes a weakening or disappearance of pain at the site of application of the gel, incl.
joint pain at rest and during movement, reduces morning stiffness and swelling of the joints.
Promotes an increase in range of motion. Pharmacokinetics When the gel is applied, the concentration of the active substance in the systemic circulation is extremely low.
after a single application, it is noted by the end of the first day, its value is more than 300 times lower than that for oral dosage forms of nimesulide.
No traces of the main metabolite of nimesulide, 4-hydroxynimesulide, are found in the blood. Indications for use Local symptomatic treatment of inflammatory and degenerative diseases of the musculoskeletal system:
articular syndrome with exacerbation of gout
rheumatoid arthritis
psoriatic arthritis
ankylosing spondylitis
osteoarthritis
osteochondrosis with radicular syndrome
radiculitis
inflammatory lesions of ligaments, tendons, bursitis
sciatica, lumbago
muscle pains of rheumatic and non-rheumatic origin
post-traumatic inflammation of soft tissues and musculoskeletal system (damage and ruptures of ligaments, bruises). Contraindications to use Increased sensitivity to nimesulide and drug components
erosive and ulcerative lesions of the gastrointestinal tract in the acute phase
bleeding from the gastrointestinal tract
dermatoses, epidermal damage and skin infections in the area of application
severe renal failure (CC < 30 ml / min)
severe liver failure
an indication of a history of bronchospasm in connection with the use of acetylsalicylic acid or other NSAIDs
pregnancy
lactation period (breastfeeding)
children under 7 years of age.
With care: liver failure
renal failure
severe heart failure
arterial hypertension
type 2 diabetes mellitus
old age, children's age. Dosing regimen
Before applying the gel, wash and dry the skin surface.
Apply a column of gel about 3 cm long in a uniform thin layer to the area of maximum pain, without rubbing, 3-4 times / day.
The amount of gel and the frequency of its application (no more than 4 times / day) may vary depending on the size of the treated area and the patient's response.
Do not use the gel for more than 10 days without consulting a doctor. Overdose Cases of drug overdose are not described.
However, when a large amount of gel (more than 50 g) is applied to large areas of the skin,
Name ENG
NISE
Clinical and pharmacological group
NSAIDs for external use
ATX code
Nimesulide
Dosage
1% x 50g
Structure
1 g contains nimesulide 10 mg
excipients: N-methyl-2-pyrrolidone, propylene glycol, macrogol, isopropanol, carbomer 940, butylhydroxyanisole, thimerosal, potassium phosphate, water, flavor
Indications
Local symptomatic treatment of inflammatory and degenerative diseases of the musculoskeletal system:
articular syndrome with exacerbation of gout
rheumatoid arthritis
psoriatic arthritis
ankylosing spondylitis
osteoarthritis
osteochondrosis with radicular syndrome
radiculitis
inflammatory lesions of ligaments, tendons, bursitis
sciatica, lumbago
muscle pains of rheumatic and non-rheumatic origin
post-traumatic inflammation of soft tissues and musculoskeletal system (injuries and ruptures of ligaments, bruises).
Storage conditions and periods
At a temperature not exceeding 25 degrees (do not freeze).
Expiration date: 2 years
Contraindications
hypersensitivity to nimesulide and drug components
erosive and ulcerative lesions of the gastrointestinal tract in the acute phase
bleeding from the gastrointestinal tract
dermatoses, epidermal damage and skin infections in the area of application
severe renal failure (CC < 30 ml / min)
severe liver failure
an indication of a history of bronchospasm in connection with the use of acetylsalicylic acid or other NSAIDs
pregnancy
lactation period (breastfeeding)
children under 7 years of age.
With care: liver failure
renal failure
severe heart failure
arterial hypertension
type 2 diabetes mellitus
old age, children.
INN / Active ingredient
Nimesulide
Specifications
Scope of the medicinal product
General
Release form
Gel
Manufacturer country
India
Package quantity, pcs
one
Scope of application
Orthopedics
Minimum age from
7 years
Way of introduction
Locally
,
Outwardly
Vacation conditions
Without recipe
Brand name
Dr.
Reddy's
The amount of the dosage form in the primary package
50 g
Primary packaging type
Tuba
Type of consumer packaging
Pack of cardboard
Pharmaco-therapeutic group
NSAIDs
Anatomical and therapeutic characteristics
M01AX17 Nimesulide
Dosage form
Gel for external use
Expiration date in days
730
Dosage (volume) of the substance in the preparation
1 g of gel contains: nimesulide 10 mg
Drug action
Pain reliever
,
Anti-inflammatory
Package weight, g
fifty
Category
:
Bruises, sprains
,
Joints
,
Treatment of diseases of the musculoskeletal system
,
Synovial fluid
,
Bone metabolism
Mode of application
:
Outwardly.
Wash and dry the skin surface before applying the gel.
Apply an even thin layer of a column of gel about 3 cm long on the area of maximum pain, without rubbing, 3-4 times a day. < br> The amount of gel and the frequency of its use (no more than 4 times a day) may vary depending on the size of the treated area and the patient's reactions. < br> Do not use the gel for more than 10 days without consulting a doctor.
Information on technical characteristics, delivery set, country of manufacture