Gel for external use Dr. Reddy's Nise, 1%, 100 g
Dosage:
1% x 100g
1% x 20g
1% x 50g
Category
Bruises, sprains
Scope of the drug
General
Release form
Gel
Manufacturer country
India
Package quantity, pcs
one
Release form
Gel for external use
pharmachologic effect
Nise gel is a new generation non-steroidal anti-inflammatory drug (NSAID) from the sulfonamide class.
It has a local anesthetic and anti-inflammatory effect.
Nimesulide is a selective competitive reversible type II cyclooxygenase inhibitor (endoperoxide prostaglandin H2 synthetase).
Reduces the concentration of short-lived prostaglandin H2, a substrate for kinin-stimulated synthesis of prostaglandin E2, in the focus of inflammation and in the ascending pathways of pain impulses in the spinal cord.
A decrease in the concentration of prostaglandin E2 (a mediator of inflammation and pain) reduces the activation of prostanoid receptors of the EP type, which manifests itself in analgesic and anti-inflammatory effects.
When applied topically, it causes a weakening or disappearance of pain at the site of application of the gel, including pain in the joints at rest and during movement, reduces morning stiffness and swelling of the joints.
Promotes increased range of motion.
Indications
Local symptomatic treatment of inflammatory and degenerative diseases of the musculoskeletal system (articular syndrome during exacerbation of gout, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, osteoarthritis, osteochondrosis with radicular syndrome, radiculitis, inflammatory lesions of ligaments, tendons, ilias, bursitis).
Muscle pains of rheumatic and non-rheumatic origin.
Post-traumatic inflammation of soft tissues and musculoskeletal system (damage and ruptures of ligaments, bruises).
Contraindications
Hypersensitivity to nimesulide and drug components
erosive and ulcerative lesions of the gastrointestinal tract in the stage of exacerbation, bleeding from the gastrointestinal tract, dermatoses, damage to the epidermis and infection of the skin in the area of application
severe renal (creatinine clearance less than 30 ml / min.) or hepatic failure, an indication in the history of bronchospasm phenomena associated with the use of acetylsalicylic acid or other NSAIDs, pregnancy and lactation, children under 7 years of age.
Carefully:
Liver failure
renal failure
severe heart failure
arterial hypertension
type 2 diabetes mellitus
elderly and children.
Application during pregnancy and lactation
Contraindicated during pregnancy and lactation.
special instructions
The drug is recommended to be applied only to intact skin areas, avoiding contact with open wounds.
Avoid getting the gel in the eyes and other mucous membranes.
Do not use the gel under airtight dressings.
After applying the gel, wash your hands with soap and water.
Close the tube tightly after using the gel.
Structure
1 g contains nimesulide 10 mg
excipients: N-methyl-2-pyrrolidone, propylene glycol, macrogol, isopropanol, carbomer 940, butylhydroxyanisole, thimerosal, potassium phosphate, water, flavor
Method of administration and dosage
Outwardly.
Wash and dry the skin surface before applying the gel.
Apply a column of gel approximately 3 cm long in a uniform thin layer to the area of maximum pain, without rubbing, 3-4 times a day.
The amount of gel and the frequency of its application (no more than 4 times a day) may vary depending on the size of the treated area and the patient's response.
Do not use the gel for more than 10 days without consulting a doctor.
Side effects
Local reactions: itching, urticaria, peeling, transient skin discoloration (not requiring discontinuation of the drug).
If any adverse reactions occur, you should stop using the drug and consult your doctor.
When the gel is applied to large areas of the skin or with prolonged use, the development of systemic side reactions is not excluded: heartburn, nausea, vomiting, diarrhea, gastralgia, ulceration of the gastrointestinal tract mucosa, increased activity of hepatic" transaminases
headache, dizziness
fluid retention, hematuria
allergic reactions (anaphylactic shock, skin rash)
thrombocytopenia, leukopenia, anemia, agranulocytosis, prolonged bleeding time.
Drug interactions
Pharmacokinetic interaction with drugs competing for the connection with blood plasma proteins is not excluded.
Care should be taken with the simultaneous use of Nise with digoxin, phenytoin, lithium preparations, diuretics, cyclosporine, methotrexate, other NSAIDs, antihypertensive and antidiabetic agents.
Before using the gel, you should consult your doctor if you are using these products or are under medical supervision.
Storage conditions
In a dry, dark place at a temperature not exceeding 25 ° C.
Do not freeze.
Keep out of the reach of children!
Shelf life
2 years.
Active substance
Nimesulide
Name ENG
NISE
Clinical and pharmacological group
NSAIDs for external use
ATX code
Nimesulide
Dosage
1% x 100g
Structure
1 g contains nimesulide 10 mg excipients: N-methyl-2-pyrrolidone, propylene glycol, macrogol, isopropanol, carbomer 940, butylhydroxyanisole, thimerosal, potassium phosphate, water, flavor
Indications
Local symptomatic treatment of inflammatory and degenerative diseases of the musculoskeletal system (articular syndrome with exacerbation of gout, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, osteoarthritis, osteochondrosis with radicular syndrome, radiculitis, inflammatory ligament damage, tendons, muscles, bursae). pains of rheumatic and non-rheumatic origin Post-traumatic inflammation of soft tissues and musculoskeletal system (injuries and ruptures of ligaments, bruises)
INN / Active ingredient
Nimesulide
Contraindications
Hypersensitivity to nimesulide and drug components
erosive and ulcerative lesions of the gastrointestinal tract in the stage of exacerbation, bleeding from the gastrointestinal tract, dermatoses, damage to the epidermis and infection of the skin in the area of application
severe renal (creatinine clearance less than 30 ml / min.) or hepatic failure, an indication in the history of bronchospasm phenomena associated with the use of acetylsalicylic acid or other NSAIDs, pregnancy and lactation, children under 7 years of age.
Storage conditions and periods
At a temperature not exceeding 25 degrees (do not freeze).
Expiration date: 2 years
Specifications
Category
Bruises, sprains
Scope of the drug
General
Release form
Gel
Manufacturer country
India
Package quantity, pcs
one
Scope of application
Orthopedics
Minimum age from
7 years
Way of introduction
Locally
,
Outwardly
Vacation conditions
Without recipe
Brand name
Dr.
Reddy's
The amount of the dosage form in the primary package
100 g
Primary packaging type
Tuba
Type of consumer packaging
Pack of cardboard
Pharmaco-therapeutic group
NSAIDs
Anatomical and therapeutic characteristics
M01AX17 Nimesulide
Dosage form
Gel for external use
Expiration date in days
730
Dosage (volume) of the substance in the preparation
nimesulide 10 mg
Drug action
Pain reliever
,
Anti-inflammatory
The target audience
Adult
Package weight, g
130
Mode of application
:
Outwardly.
Wash and dry the skin surface before applying the gel.
Apply an even thin layer of a column of gel about 3 cm long on the area of maximum pain, without rubbing, 3-4 times a day. < br> The amount of gel and the frequency of its use (no more than 4 times a day) may vary depending on the size of the treated area and the patient's reactions. < br> Do not use the gel for more than 10 days without consulting a doctor.
Information on technical characteristics, delivery set, country of manufacture "