Gaviscon double action suspension 10ml, No. 12

Gaviscon double action suspension 10ml, No. 12; 'Symptomatic treatment of diseases associated with indigestion, increased acidity of gastric juice and gastroesophageal reflux (heartburn, sour belching), feeling of heaviness in the stomach after eating, including during pregnancy.

Inside.

Adults and children over 12 years old: 10 - 20 ml after meals and before bedtime (up to 4 times a day). The maximum daily dose is 80 ml. For elderly patients, dose changes are not required. You should not use the drug for a long time, if symptoms persist after 7 days of taking the drug, you should consult a doctor to review therapy.

10 ml of suspension contains:

active ingredients: sodium alginate 500 mg, sodium bicarbonate 213 mg, calcium carbonate 325 mg;

excipients: carbomer (974R) 65 mg, methyl parahydroxybenzoate 40 mg, propyl parahydroxybenzoate 6 mg, sodium hydroxide 26.67 mg, sodium saccharinate 10 mg, mint flavor 6 mg, purified water up to 10 ml.

Х hypersensitivity to any component of the drug;

Х renal failure of moderate and severe severity;

Х children under 12 years of age.

Carefully:

If you have the following diseases or conditions, you should consult your doctor before using the drug: hypercalcemia, nephrocalcinosis, urolithiasis with the formation of calcium oxalate stones, congestive heart failure, hypophosphatemia, mild renal failure.

Application during pregnancy and breastfeeding:

Clinical studies involving more than 500 pregnant women and the amount of data obtained in the post-registration period did not show congenital, fetal and neonatal toxicity of the active substances. Gaviscon Ѓ Dual Action can be used during pregnancy if clinically necessary. Taking into account the presence of calcium carbonate in the composition, it is recommended to reduce the duration of the drug use. The effect of the active ingredients of the drug on newborns, infants, and also on lactating women has not been demonstrated. GavisconЃ Dual Action can be used during breastfeeding

Pharmacology.

This drug is a combination of alginate and antacids (calcium carbonate and sodium bicarbonate). When taken orally, the active ingredients of GavisconЃ Double Action react quickly with the acidic contents of the stomach. This forms an alginate gel with a pH value close to neutral. Within three minutes, the gel forms a protective barrier on the surface of the stomach contents, preventing gastroesophageal reflux (reflux of stomach contents into the esophagus) for up to four hours. In severe cases of reflux (regurgitation), the gel enters the esophagus ahead of the rest of the gastric contents, where it reduces irritation of the esophageal mucosa. Calcium carbonate quickly neutralizes the hydrochloric acid in the gastric juice, relieving the sensation of heartburn.This effect is enhanced by the presence of sodium bicarbonate in the preparation, which also has a neutralizing effect. The total acid-neutralizing activity of the drug in a minimum dose of 10 ml is approximately 10 mEq. A decrease in irritation is felt 3-4 minutes after ingestion.

Pharmacokinetics:

The mechanism of action of GavisconЃ Dual Action is physical and does not depend on absorption into the systemic circulation. Special instructions: In 10 ml of suspension, the sodium content is 127.25 mg (5.53 mmol). This should be taken into account when it is necessary to adhere to a diet with limited salt content, for example, with congestive heart failure and renal failure of mild severity. 10 ml of suspension contains 130 mg (3.25 mmol) of calcium. Therefore, care should be taken when treating patients with hypercalcemia, nephrocalcinosis and urolithiasis with the formation of calcium oxalate stones. Gaviscon Ѓ Dual Action contains antacids that can mask the symptoms of serious gastrointestinal diseases.A decrease in the effectiveness of the drug in patients with low acidity of gastric juice is possible. Children with gastroenteritis or suspected renal failure have an increased risk of hypernatremia. The drug contains methyl parahydroxybenzoate and propyl parahydroxybenzoate, therefore it can cause allergic reactions (including delayed ones). The drug does not affect the ability to drive vehicles and mechanisms, as well as to engage in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.therefore, it can cause allergic reactions (including delayed). The drug does not affect the ability to drive vehicles and mechanisms, as well as to engage in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.therefore, it can cause allergic reactions (including delayed). The drug does not affect the ability to drive vehicles and mechanisms, as well as to engage in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Side effect:

The assessment of the incidence of adverse reactions was made on the basis of the following criteria: very often (? 1/10), often (? 1/100, <1/10), infrequently (? 1/1000, <1/100), rarely (? 1 / 10000, <1/1000), very rare (<1/10000) and unspecified frequency (frequency cannot be calculated from available data). Immune system disorders: of unknown frequency - anaphylactic and anaphylactoid reactions, hypersensitivity reactions (urticaria). Disturbances from the respiratory system, chest and mediastinal organs: of unknown frequency - respiratory effects (bronchospasm). Taking large amounts of calcium carbonate can cause alkalosis, hypercalcemia, acid rebound, milk-alkali syndrome, and constipation. These conditions usually occur with overdose.If any of the side effects indicated in the instructions are aggravated, or you notice any other side effects that are not indicated in the instructions, inform your doctor.

Overdose:

Symptoms: Abdominal bloating may occur. Treatment: symptomatic.

Interaction with other medicinal products:

Since calcium carbonate, which is part of the drug, exhibits antacid activity, at least 2 hours should elapse between taking GavisconЃ Double Action and other drugs, especially when taken simultaneously with H2-histamine receptor blockers, antibiotics from the tetracycline group, digoxin, fluoroquinolone, iron salts, ketoconazole, neuroleptics, thyroid hormones, levothyroxine sodium, penicillamine, beta-blockers (atenolol, metoprolol, propranolol), glucocorticosteroids, chloroquine, bisphosphonates and estramustine.