Gastrostat tablets 100mg, No. 30

• Stomach ulcer;

• chronic gastritis with increased acid-forming function of the stomach in the acute phase, erosive gastritis;

• prevention of damage to the mucous membrane while taking NSAIDs.

Inside, 100 mg 3 times / day. The course of treatment is 2-4 weeks, if necessary, it can be extended up to 8 weeks.

Film-coated tablets of white or almost white color, round, biconvex; in cross section, the core is white or almost white.

1 tab.

rebamipide 100 mg

Excipients: magnesium carbonate, hypromellose (hydroxypropyl methylcellulose), Kollidon CL F, sodium lauryl sulfate, citric acid, magnesium stearate.

• Pregnancy;

• lactation period;

• age under 18;

• hypersensitivity to rebamipide

pharmachologic effect

Gastroprotective agent. Rebamipide increases the content of prostaglandin E2 (PGE2) in the gastric mucosa and in the contents of gastric juice. Has a cytoprotective effect on the gastric mucosa under the damaging effects of ethanol, acids and alkalis, acetylsalicylic acid. Promotes the activation of enzymes that accelerate the biosynthesis of high molecular weight glycoproteins, and increases the mucus content on the surface of the stomach wall. It improves the blood supply to the gastric mucosa, activates its barrier function, activates the alkaline secretion of the stomach, enhances the proliferation and exchange of epithelial cells of the stomach, cleans the mucosa from hydroxyl radicals and suppresses superoxides produced by polymorphonuclear leukocytes and neutrophils in the presence of Helicobacter pylori, protects the mucous membrane of the stomachhas a gastroprotective effect when exposed to the mucous membrane of NSAIDs.

Pharmacokinetics

After oral administration at a dose of 100 mg, Cmax is reached after approximately 2 hours and is 340 ng / ml. When taken again, it does not accumulate in the body. Plasma protein binding in vitro is about 98.5%. T1 / 2 is approximately 1 hour. About 10% is excreted by the kidneys, mainly unchanged. When taken in a dose of 600 mg, traces of the hydroxylated metabolite can be isolated. Side effect From the digestive system: constipation, flatulence, diarrhea, nausea, vomiting, abdominal pain, impaired taste, heartburn. From the liver: signs of liver dysfunction, increased serum ALT and ACT. From the hematopoietic system: leukopenia, granulocytopenia. Others: menstrual irregularities.

Application during pregnancy and lactation

Use during pregnancy and lactation (breastfeeding) is contraindicated.

Application in children

The drug is contraindicated for use in children and adolescents under the age of 18 years.

special instructions

Can be used in combination therapy.

Drug interactions

When rebamipide is used as part of traditional therapy regimens for patients with Helicobacter pylori infection, the effectiveness of eradication therapy significantly increases.