Gastal tablets, No. 12 Mint

• Heartburn,

• dyspeptic symptoms (after taking medicines, alcohol, coffee, dietary errors, smoking);

Conditions accompanied by increased acidification:

• peptic ulcer and duodenal ulcer, gastritis;

• reflux esophagitis;

• hernia of the esophageal opening of the diaphragm.

Inside, gradually dissolving in the mouth.

Adults and children over 12 years of age weighing at least 50 kg
1-2 tablets 4-6 times a day approximately 1 hour after meals and before bedtime, but not more than 8 tablets per day. Duration of admission is no more than 2 weeks.
Similar doses are recommended for treating heartburn regardless of food intake.

Adults and children over 12 years old with a body weight of less than 50 kg, children aged 6 to 12 years The
dose is half of the recommended dose for adults and children over 12 years old with a body weight of at least 50 kg. Duration of admission is no more than 2 weeks.

Patients with CRF
No dose adjustment is required. Duration of admission is no more than 2 weeks.

1 tablet contains

active substances: aluminum hydroxide-magnesium carbonate gel 450.0 mg, magnesium hydroxide 300.0 mg;

excipients: mannitol (E421) 120.00 mg, sorbitol (E420) 50.00 mg, lactose monohydrate 30.00 mg, corn starch 75.80 mg, sodium tsikpamate 7.00 mg, sodium saccharinate 0.20 mg, talc 28.00 mg, magnesium stearate 6.00 mg, peppermint flavor 3.00 mg.

• Hypersensitivity to salts of aluminum, magnesium or other components of the drug;

• severe renal failure;

• Alzheimer's disease;

• hypophosphatemia;

• lactose intolerance, lactase deficiency or glucose-galactose malabsorption;

• children under 6 years of age.

With caution
In chronic renal failure (CRF), pregnancy and breastfeeding, adults and children over 12 years old with a body weight of less than 50 kg, children from 6 to 12 years old, old age.

Dosage form:

lozenges

Composition:

1 tablet contains

active substances: aluminum hydroxide-magnesium carbonate gel 450.0 mg, magnesium hydroxide 300.0 mg;

excipients: mannitol (E421) 120.00 mg, sorbitol (E420) 50.00 mg, lactose monohydrate 30.00 mg, corn starch 75.80 mg, sodium tsikpamate 7.00 mg, sodium saccharinate 0.20 mg, talc 28.00 mg, magnesium stearate 6.00 mg, peppermint flavor 3.00 mg.

Description:

Round tablets from white to cream color with a smooth surface and a bevel.

Pharmacological group: Antacid

ATX code: A02AX

Pharmacological properties

Pharmacodynamics

The drug Gastal is a combined antacid agent that reduces the increased acidity of gastric juice and does not have a stimulating effect on the secretion of gastric juice.

Aluminum hydroxide-magnesium carbonate gel and magnesium hydroxide provide immediate (immediately after ingestion) and prolonged (about 2 hours) neutralization of gastric acid hydrochloric acid, while maintaining acidity in the stomach at a physiological level (pH 3-5). One tablet of Gastal neutralizes 21.5 mmol of hydrochloric acid.

The drug GastalЃ inhibits the action of pepsin, lysolecithin and bile acids, eliminates dyspeptic symptoms. Strengthens the protective and regenerative processes in the gastric mucosa. Aluminum ions have a cytoprotective effect by increasing the secretion of mucin and sodium bicarbonate, activating prostaglandin E2 and NO, accumulating epidermal growth factor at the site of mucosal injury, and increasing the concentration of phospholipids in the walls of the stomach.

Pharmacokinetics

The drug Gastal does not have a systemic effect in patients with normal renal function. After interaction with hydrochloric acid of gastric juice, aluminum hydroxide reacts with phosphates and carbonates in the alkaline medium of the intestine and is excreted in the feces in the form of insoluble salts. Magnesium hydroxide reacts with hydrochloric acid in gastric juice to form magnesium chloride, which has osmotic properties and a mild laxative effect, which neutralizes the fixing effect of aluminum hydroxide in the small intestine. Magnesium ions are excreted in the feces as insoluble carbonate.

Indications for use

• Heartburn,

• dyspeptic symptoms (after taking medicines, alcohol, coffee, dietary errors, smoking);

Conditions accompanied by increased acidification:

• peptic ulcer and duodenal ulcer, gastritis;

• reflux esophagitis;

• hernia of the esophageal opening of the diaphragm.

Contraindications

• Hypersensitivity to salts of aluminum, magnesium or other components of the drug;

• severe renal failure;

• Alzheimer's disease;

• hypophosphatemia;

• lactose intolerance, lactase deficiency or glucose-galactose malabsorption;

• children under 6 years of age.

With caution
In chronic renal failure (CRF), pregnancy and breastfeeding, adults and children over 12 years old with a body weight of less than 50 kg, children from 6 to 12 years old, old age.

Application during pregnancy and during breastfeeding

The drug Gastal is not excreted in breast milk. When used during pregnancy and during breastfeeding, it is necessary to assess the ratio of the benefits to the mother and the risks to the fetus and the infant.

Method of administration and dosage

Inside, gradually dissolving in the mouth.

Adults and children over 12 years of age weighing at least 50 kg
1-2 tablets 4-6 times a day approximately 1 hour after meals and before bedtime, but not more than 8 tablets per day. Duration of admission is no more than 2 weeks.
Similar doses are recommended for treating heartburn regardless of food intake.

Adults and children over 12 years old with a body weight of less than 50 kg, children aged 6 to 12 years The
dose is half of the recommended dose for adults and children over 12 years old with a body weight of at least 50 kg. Duration of admission is no more than 2 weeks.

Patients with CRF
No dose adjustment is required. Duration of admission is no more than 2 weeks.

Overdose

Symptoms of acute overdose have not been described.
With prolonged use of high doses of drugs containing aluminum and magnesium, hypophosphatemia, hypocalcemia, hypercalciuria, osteomalacia, osteoporosis, hypermagnesemia, hyperaluminaemia, encephalopathy, nephrocalcinosis and renal dysfunction are possible. The development of more pronounced adverse reactions from the gastrointestinal tract (GIT) (constipation, diarrhea) is possible, in patients with renal failure - thirst, lowering blood pressure, hyporeflexia.

Treatment: symptomatic therapy.

Side effect

When using the drug in recommended doses, adverse reactions are rare (not less than 0.01%, but less than 0.1%): nausea, constipation, diarrhea, change in taste. In exceptional cases, allergic reactions are possible.

Interaction with other medicinal products

The drug Gastal, when used simultaneously, enhances the activity of levodopa and nalidixic acid, reduces and slows down the absorption of quinolones, isoniazid, naproxen, iron preparations, indomethacin, chlorpromazine, beta-blockers, diflunisal, blockers of H2-histamine receptors, vitamins, insoluble antioxidants.

When interacting with metal ions that make up antacids, tetracyclines form insoluble chelate complexes; as a result of this interaction, the absorption of tetracyclines is reduced by more than 90%. Simultaneous administration of these drugs is not possible. If combined use is necessary, tetracycline should be taken at least 2 hours before taking the antacid.

In the presence of aluminum and magnesium hydroxides contained in the antacid, the absorption of ciprofloxacin and ofloxacin is reduced by 50-90%.

In the presence of antacids, the bioavailability of captopril is significantly reduced, and the combined use of antacids and metoprolol leads to a decrease in the concentration of metoprolol in the blood plasma.

The simultaneous use of high doses of antacids can reduce the absorption of ranitidine by 10-33%.

The use of antacids does not affect the bioavailability of amoxicillin, cephalexin and the combination of amoxicillin and clavulanic acid, however, it can significantly reduce the absorption of doxycycline from the gastrointestinal tract.

An increase in urine pH during antacid therapy can increase tubular reabsorption of basic (alkaline) drugs and reduce the reabsorption of acidic compounds. Antacids can reduce and slow down the absorption of salicylates, including acetylsalicylic acid, as well as, by increasing the pH of the urine, promote faster excretion of salicylates in the urine from the body, with a concomitant decrease in their concentration in serum by 30-70%. The absorption of cardiac glycosides, including digoxin and digitoxin, does not significantly decrease when used simultaneously with antacids. M-anticholinergics, slowing down gastric motility, increase the duration of the action of the drug GastalЃ.

In order to prevent possible interaction of GastalЃ with other drugs, it is recommended to take it 1 hour before or 1 hour after their use.

special instructions

The recommended dose and duration of treatment should not be exceeded when used in patients with impaired renal function.

Influence on the ability to drive vehicles and work with equipment
The use of the drug Gastal does not affect the ability to drive vehicles and control other mechanisms.

Release form

Lozenges.
6 tablets in a PVC / aluminum foil blister.
2, 4, 5, 8 or 10 blisters with instructions for use in a cardboard box.

Storage conditions

Store at a temperature not exceeding 25 ? C. Keep out of the reach of children.

Shelf life

3 years.
Do not use after the expiration date printed on the package.

Conditions of dispensing from pharmacies

Without recipe.