Galavit rectal suppositories 100mg, No. 10

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Expiration Date: 05/2027

Russian Pharmacy name:

Галавит суппозитории ректальные 100мг, №10

Galavit rectal suppositories 100mg, No. 10

As an immunomodulatory and anti-inflammatory agent in the complex therapy of immunodeficiency states in adults and adolescents over 12 years old:

- infectious and inflammatory urogenital diseases (urethritis of chlamydial and Trichomonas etiology, chlamydial prostatitis, acute and chronic salpingo-oophoritis, endometritis);

- purulent-inflammatory diseases of the pelvic organs;

- chronic recurrent diseases caused by the herpes virus;

- diseases caused by the papilloma virus;

- postoperative rehabilitation of patients with uterine myoma;

- complications of the postoperative period in women of reproductive age;

- postoperative purulent-septic complications and their prevention (including in cancer patients);

- chronic recurrent furunculosis, erysipelas;

- non-specific prevention and treatment of influenza and acute respiratory infections.

- inflammatory diseases of the mucous membrane of the mouth and throat,

periodontal disease;

- viral hepatitis;

- infectious intestinal diseases accompanied by intoxication

and / or diarrhea;

- peptic ulcer and 12 duodenal ulcer;

- asthenic conditions, neurotic and somatoform disorders, decreased physical performance (including in athletes); mental, behavioral and post-withdrawal disorders in alcohol and drug addiction;

Rectally. The suppository is released from the contour packaging and then injected

into the rectum. It is recommended to empty the intestines first.

The dose and duration of the drug depends on the nature, severity and duration of the disease.

- For urogenital diseases - urethritis of chlamydial and Trichomonas etiology, chlamydial prostatitis : 1 day, 1 suppository twice, then one every other day. Course of 10-15 suppositories (depending on the severity

pathological process).

- With salpingo-oophoritis, endometritis in the acute period: 2 days, 2 suppositories 1 time per day, then one at a time of 72 hours. In the chronic period: 5 days, 1 suppository 1 time per day, then one every 72 hours. Course - 20 suppositories.

- In acute and chronic purulent diseases of the pelvic organs - in the acute period: 1 day 2 suppositories once, 3 days, one suppository daily, then one every other day for 5 days. Course - 10 suppositories. In the chronic period: 5 days, 1 suppository 1 time per day, then

one every 72 hours. Course - 20 suppositories.

- For chronic recurrent diseases caused by the herpes virus: 1 suppository daily 5 suppositories, then one at a time

day - 15 suppositories.

- For diseases caused by the papilloma virus: 5 days, 1 suppository once a day, then one suppository every other day. Course - 20 suppositories.

- For postoperative rehabilitation of patients with uterine fibroids and

complications of the postoperative period in women of reproductive age: 5 days, 1 suppository once a day, then one at a time every other day. Course - 15 suppositories.

- For the prevention and treatment of surgical complications in the pre- and postoperative period (including in cancer patients): 1 suppository is prescribed 1 time per day - 5 suppositories before surgery, 5 - after surgery, one every other day and 5 suppositories - c at intervals of 72 hours. When

severe course of the disease, the initial dose of 2 suppositories once or 2 times a day, one at a time. Course - 20 suppositories.

- For chronic recurrent furunculosis, erysipelas: 5 days, one suppository once a day, then one at a time every other day. Course - 20 suppositories.

- For non-specific prophylaxis and treatment of influenza and acute respiratory infections: one suppository once a day. Course 5 days.

- For inflammatory diseases of the oral mucosa and throat, periodontal diseases: an initial dose of 1 suppository daily - 5 suppositories, then one at a time - with an interval of 72 hours. Course of 15 suppositories.

- For viral hepatitis: the initial dose is 2 suppositories once, then one - 2 times a day until the symptoms of intoxication and inflammation are relieved. Subsequent continuation of the course of 1 suppository with an interval of 72 hours. Course 20-25 suppositories.

- For acute infectious intestinal diseases accompanied by diarrheal syndrome: the initial dose is 2 suppositories once, then 1 suppository 2 times a day until the symptoms of intoxication are relieved. Possible further continuation of the course of 1 suppository with an interval of 72

hours. A course of 20-25 suppositories.

- In case of gastric ulcer and duodenal ulcer in the acute period: 2 days, 2 suppositories 1 time per day, then 1 suppository with an interval of 72

hours. The course is 15-25 suppositories. In the chronic period: 5 days, 1 suppository 1 time per day, then one at a time - after 72 hours. Course of 20 suppositories.

- In asthenic conditions, neurotic and somatoform disorders, in mental, behavioral and post-withdrawal disorders, in patients with alcohol and drug addiction: 5 days, one suppository daily, then one suppository every 72 hours. Course 15-20

suppositories.

- To increase physical performance: 1 suppository every other day - 5 suppositories, then one at a time - after 72 hours, the course - up to 20 suppositories.

The active ingredient is sodium aminodihydrophthalazinedione (GalavitЃ) 100 mg;

auxiliary substances - witepsol W-35 (fatty acids glycerides) - 575 mg, witepsol H-15 (fatty acids glycerides) - 575 mg.

  • Hypersensitivity to Galavit and other components of the drug,

  • pregnancy and the period of breastfeeding,

  • children under 12 years of age.

Pharmacological properties:

Pharmacodynamics

The mechanism of action of the drug is associated with its ability to regulate

functional and metabolic activity of cells of innate and adaptive immunity (monocytes, macrophages, neutrophils, natural killer cells, etc.). Galavit normalizes phagocytic activity of monocytes / macrophages, bactericidal activity of neutrophils and cytotoxic activity of NK cells.

At the same time, restoring the reduced activity of cells of innate and adaptive immunity, the drug increases the body's resistance to infectious diseases.

In addition, Galavit normalizes antibody production, increases the functional activity (affinity) of antibodies.

In inflammatory diseases, the drug reversibly inhibits the excessive synthesis of tumor necrosis factor-?, interleukin-1, interleukin-6 and other pro-inflammatory cytokines by hyperactivated macrophages, the level of which determines the degree of inflammatory reactions, their

cyclicality, as well as the severity of intoxication of the body. Galavit reduces the production of reactive oxygen species by hyperactivated macrophages, thus

thereby reducing the level of oxidative stress and protecting tissues and organs from the damaging effects of radicals.

Normalization of excessively increased functional activity of phagocytic cells leads to the restoration of their antigen-presenting and regulatory functions, a decrease in the level of auto-aggression.

The drug has no allergenic, mutagenic, embryotoxic, teratogenic and carcinogenic effects.

Pharmacokinetics

It is excreted from the body, mainly through the kidneys. After rectal administration

the half-life is 40-60 minutes. The main pharmacological effects are observed within 72 hours. Aminodihydrophthalazinedione sodium in suppositories for rectal administration has a high bioavailability, and therefore both local and pronounced systemic action is achieved.

Side effects:

In rare cases, allergic reactions are possible. If you have any side effects indicated in the instructions or they are aggravated, or you notice any other side effects not listed in the instructions, inform your doctor.

Overdose:

Overdose cases were not noted.

Interaction with other medicinal products:

With simultaneous use, it is possible to reduce the course doses of antibiotics. No cases of incompatibility with other drugs have been reported.

Special instructions:

To prevent urogenital infection, it is recommended to consider concomitant treatment of the sexual partner.

Influence on the ability to drive vehicles, mechanisms:

Has not been studied.

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