Fungoterbin cream 1%, 15 g

Treatment and prevention:

• fungal infections of the skin: mycoses of the feet ('fungus' of the foot), inguinal epidermophytosis (tinea cruris), fungal lesions of the smooth skin of the body (tinea corporis) caused by dermatophytes Trichophyton spp., incl. Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton verrucosum, Trichophyton violaceum, Microsporum canis and Epidermophyton floccosum;

• skin infections caused by yeast-like fungi of the genus Candida (eg, Candida albicans);

• pityriasis versicolor, caused by Pityrosporum orbiculare (synonym - Malassezia furfur);

For adults and children aged 12 years and older, the drug is applied to the skin 1-2 times / day. Before applying the drug, it is necessary to clean and dry the affected areas.

The cream is applied in a thin layer to the affected skin and surrounding areas and rubbed lightly.

For infections accompanied by diaper rash (under the mammary glands, in the interdigital spaces, between the buttocks, in the groin area), the places where the cream is applied can be covered with gauze, especially at night.

With dermatomycosis of the trunk, legs, stop cream should be applied for 1 week 1 time / day; with candidiasis of the skin - within 1-2 weeks 1-2 times / day; with multi-colored lichen - within 1 week 1-2 times / day.

It is not required to change the dosage regimen of the drug for elderly patients.

Cream for external use 1% white or almost white, with a subtle scent.

1 g

terbinafine hydrochloride 10 mg

Excipients: butylhydroxytoluene (dibunol - 0.1), urea (carbamide), macrogol 20 cetostearyl ether, cetostearyl alcohol, proxanol-268 (poloxamer 407), imidourea, propylene glycol, liquid petrolatum oil, medical paraffin water) (paraffinic water)

• Children under 12 years of age;

• hypersensitivity to terbinafine or another component of the drug;

  Fungoterbin spray should be used with caution in case of hepatic and / or renal failure, alcoholism, inhibition of bone marrow hematopoiesis, tumors, metabolic diseases, occlusive vascular diseases of the extremities.

pharmachologic effect

Antifungal drug for external use from the group of allylamines. Possesses a wide spectrum of antifungal action.

Terbinafine disrupts the early stages of ergosterol biosynthesis in fungi. This leads to a deficiency of ergosterol and to intracellular accumulation of squalene, which causes the death of the fungal cell. Terbinafine works by inhibiting the enzyme squalene epoxidase located on the cell membrane of the fungus. This enzyme does not belong to the cytochrome P450 system.

Terbinafine in small concentrations has a fungicidal effect against dermatophytes (including Trychophyton rubrum, Trychophyton mentagrophytes, Trychophyton verrucosum, Trychophyton violaceum, Trychophyton tonsurans, Microsporum canis, Epidermophyton floccosum), molds (mainly Candida albida Pityrosporum orbiculare), leading to their death. Activity against yeast-like fungi, depending on their type, can be fungicidal or fungistatic.

Urea, which is part of the spray, has keratolytic (softens and causes rejection of the stratum corneum of the epidermis affected by a fungal infection) and moisturizing effects, urea is able to increase the penetration of the dosage form into the skin and create high concentrations of terbinafine in the skin. Urea contributes to the rapid recovery of the epidermis.

Butylhydroxytoluene, which is part of the spray, is an antioxidant agent that stimulates regeneration processes. When applied topically, inhibits free radical reactions.

Terbinafine does not affect the metabolism of hormones or other drugs.

Pharmacokinetics

When applied externally, absorption is 5%, it has a slight systemic effect.

Side effect

Local reactions: rarely - redness, itching or burning sensation at the site of application of the drug. Discontinuation of treatment is rarely required.

Allergic reactions: rarely - generalized rash and / or redness, urticaria, angioedema, repeated allergic reaction.

Application during pregnancy and lactation

Since the clinical experience of using the drug in pregnant women is very limited, FungoterbinЃ spray should be used only under strict indications, when the intended benefit to the mother will outweigh the potential risk to the fetus.

Terbinafine is excreted in breast milk. However, when using FungoterbinЃ cream or spray in a nursing mother, a small amount of the active substance is absorbed through the skin, therefore, an adverse effect on the infant is unlikely.

In experimental studies, no teratogenic properties of terbinafine have been identified. To date, no malformations have been reported with the FungoterbinЃ spray.

Application for violations of liver function

Fungoterbin spray should be used with caution in liver failure.

Application for impaired renal function

Fungoterbin spray should be used with caution in case of renal failure.

Application in children

The experience of drug treatment in children is limited, and therefore the use of FungoterbinЃ spray in children under the age of 12 is not recommended.

Use in elderly patients

It is not required to change the dosage regimen of the drug for elderly patients.

special instructions

A decrease in the severity of clinical manifestations is usually noted in the first days of treatment. With irregular use of the drug or premature termination of treatment, there is a risk of re-infection. If after 2 weeks of treatment there are no signs of improvement, the diagnosis should be verified.

The cream and spray are for external use only. Avoid contact with eyes and mucous membranes. In case of accidental contact of the drug in the eyes, they should be immediately rinsed with running water. If persistent irritation develops, consult your doctor.

Overdose

No cases of overdose of FungoterbinЃ have been reported.

In case of accidental ingestion, one can expect the development of such side effects as nausea, impaired appetite, pain in the upper abdomen, diarrhea. You should also take into account the presence of ethanol in the preparation.