fosfomycin | Monural granules for solution for oral administration 3 g sachets 2 pcs.
Special Price
$28.13
Regular Price
$36.00
In stock
SKU
BID500114
Release form
Granules for oral solution.
Granules for oral solution.
Release form
Granules for oral solution.
Packaging
1 sachet.
Pharmacological action
A broad-spectrum antibiotic, a derivative of phosphonic acid, has a bactericidal effect, the mechanism of which is associated with the suppression of the first stage of bacterial cell wall synthesis. It is a structural analogue of phosphoenol pyruvate and enters into competitive interaction with the enzyme N-acetyl-glucosamine-3-o-enolpyruvyl transferase.
The result is a specific, selective and irreversible inhibition of this enzyme, which ensures the absence of cross-resistance with other classes of antibiotics and the possibility of synergism with other antibiotics (synergies with amoxicillin, cephalexin, pipemidic acid are noted in vitro).
Active in vitro against most gram-positive microorganisms: Enterococcus spp., Enterococcus faecalis, Staphylococcus aureus, Staphylococcus saprophyticus, Staphylococcus spp. Gram-negative microorganisms: Esherichia coli, Citrobacter spp., Enterobacter spp., Klebsiella spp., Klebsiella pneumoniae, Morganella morganii, Proteus mirabilis, Pseudomonas spp., Serratia spp. In vitro fosfomycin reduces the adhesion of a number of bacteria to the epithelium of the urinary tract.
Contraindications
- severe renal failure (KK
- children younger than 5 years old
- hypersensitivity to the components of the drug.
Special instructions
When prescribing Monural to patients with diabetes mellitus, it should be borne in mind that 1 packet containing 2 g of phosphomycin contains 2.1 g of sucrose, and 1 packet containing 3 g of phosphomycin contains 2.213 g of sucrose.
Composition
Fosfomycin trometamol 5.631 g, incl. fosfomycin 3 g.
Excipients:
tangerine flavor,
orange flavor,
saccharin,
sucrose.
Dosage and administration of
For adults, the drug is prescribed 3 g 1 time / day. The course of treatment is 1 day. If necessary (for severe or recurring infections, the elderly), it is possible to re-take the drug in a dose of 3 g after 24 hours.
In order to prevent infection of the urinary tract during surgery, transurethral diagnostic procedures, the drug is taken in a dose of 3 g 3 hours before the intervention and 3 g 24 hours after the first dose.
For children over 5 years of age, the drug is prescribed in a dose of 2 g only once.
When prescribing the drug to patients with renal failure, the dose should be reduced and the interval between doses should be increased.
Before taking, the granules are dissolved in 1/3 cup of water. The drug is taken 1 time / day on an empty stomach 2 hours before or after meals (preferably before bedtime), after emptying the bladder.
Side effects
From the side of the digestive system: nausea, heartburn, diarrhea.
Other: skin rash, allergic reactions.
Drug interaction
With simultaneous use with metoclopramide, a decrease in the concentration of fosfomycin in blood serum and urine is possible (this combination is not recommended).
overdose
The risk of overdose is minimal.
Treatment: forced diuresis.
Storage Conditions
The product should be stored out of the reach and sight of children.
Shelf life
3 years.
Deystvuyushtee substance
Fosfomycin
Terms and conditions
prescription
Possible product names
Monural granules for solution for oral administration 3 g sachets 2 pcs.
Zambon S.p.A., Italy
Granules for oral solution.
Packaging
1 sachet.
Pharmacological action
A broad-spectrum antibiotic, a derivative of phosphonic acid, has a bactericidal effect, the mechanism of which is associated with the suppression of the first stage of bacterial cell wall synthesis. It is a structural analogue of phosphoenol pyruvate and enters into competitive interaction with the enzyme N-acetyl-glucosamine-3-o-enolpyruvyl transferase.
The result is a specific, selective and irreversible inhibition of this enzyme, which ensures the absence of cross-resistance with other classes of antibiotics and the possibility of synergism with other antibiotics (synergies with amoxicillin, cephalexin, pipemidic acid are noted in vitro).
Active in vitro against most gram-positive microorganisms: Enterococcus spp., Enterococcus faecalis, Staphylococcus aureus, Staphylococcus saprophyticus, Staphylococcus spp. Gram-negative microorganisms: Esherichia coli, Citrobacter spp., Enterobacter spp., Klebsiella spp., Klebsiella pneumoniae, Morganella morganii, Proteus mirabilis, Pseudomonas spp., Serratia spp. In vitro fosfomycin reduces the adhesion of a number of bacteria to the epithelium of the urinary tract.
Contraindications
- severe renal failure (KK
- children younger than 5 years old
- hypersensitivity to the components of the drug.
Special instructions
When prescribing Monural to patients with diabetes mellitus, it should be borne in mind that 1 packet containing 2 g of phosphomycin contains 2.1 g of sucrose, and 1 packet containing 3 g of phosphomycin contains 2.213 g of sucrose.
Composition
Fosfomycin trometamol 5.631 g, incl. fosfomycin 3 g.
Excipients:
tangerine flavor,
orange flavor,
saccharin,
sucrose.
Dosage and administration of
For adults, the drug is prescribed 3 g 1 time / day. The course of treatment is 1 day. If necessary (for severe or recurring infections, the elderly), it is possible to re-take the drug in a dose of 3 g after 24 hours.
In order to prevent infection of the urinary tract during surgery, transurethral diagnostic procedures, the drug is taken in a dose of 3 g 3 hours before the intervention and 3 g 24 hours after the first dose.
For children over 5 years of age, the drug is prescribed in a dose of 2 g only once.
When prescribing the drug to patients with renal failure, the dose should be reduced and the interval between doses should be increased.
Before taking, the granules are dissolved in 1/3 cup of water. The drug is taken 1 time / day on an empty stomach 2 hours before or after meals (preferably before bedtime), after emptying the bladder.
Side effects
From the side of the digestive system: nausea, heartburn, diarrhea.
Other: skin rash, allergic reactions.
Drug interaction
With simultaneous use with metoclopramide, a decrease in the concentration of fosfomycin in blood serum and urine is possible (this combination is not recommended).
overdose
The risk of overdose is minimal.
Treatment: forced diuresis.
Storage Conditions
The product should be stored out of the reach and sight of children.
Shelf life
3 years.
Deystvuyushtee substance
Fosfomycin
Terms and conditions
prescription
Possible product names
Monural granules for solution for oral administration 3 g sachets 2 pcs.
Zambon S.p.A., Italy
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