Folic acid 9 MONTHS tablets p / o 400mkg, No. 30

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BIDL3178306
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Expiration Date: 05/2027

Russian Pharmacy name:

Фолиевая кислота 9МЕСЯЦЕВ таблетки п/о 400мкг, №30

Folic acid 9 MONTHS tablets p / o 400mkg, No. 30

  • Folic acid deficiency.

  • Prevention of the development of neural tube defects in the fetus in the first trimester of pregnancy.

Administered orally after meals.

With a deficiency of folic acid - 400 mcg (1 tab) per day.

For the prevention of the development of neural tube defects in the fetus in the 1st trimester of pregnancy - 400 mcg - 800 mcg (1-2 tablets).

1 tablet contains:

active substance :

folic acid - 0.0004 g.

auxiliary substances :

lactose monohydrate - 0.0936 g, colloidal silicon dioxide - 0.0005 g, copovidone - 0.0050 g, magnesium stearate - 0.0005 g;

shell: Opadray II 85F22233 - 0.0030 g: partially hydrolyzed polyvinyl alcohol - 40.00%, macrogol - 20.20%, talc - 14.80%, titanium dioxide E 171 - 19.50%, iron dye yellow oxide E 172 - 0.10%, aluminum varnish based on quinoline yellow dye E 104 -5.40%.

  • Hypersensitivity to the components that make up the drug;

  • pernicious anemia

  • malignant neoplasms

  • cobalamin deficiency

  • childhood.

Trade name of the drug

9 months Folic acid

International non-proprietary name

Folic acid

Dosage form

film-coated tablets

Composition

1 tablet contains:

active substance :

folic acid - 0.0004 g.

auxiliary substances :

lactose monohydrate - 0.0936 g, colloidal silicon dioxide - 0.0005 g, copovidone - 0.0050 g, magnesium stearate - 0.0005 g;

shell: Opadray II 85F22233 - 0.0030 g: partially hydrolyzed polyvinyl alcohol - 40.00%, macrogol - 20.20%, talc - 14.80%, titanium dioxide E 171 - 19.50%, iron dye yellow oxide E 172 - 0.10%, aluminum varnish based on quinoline yellow dye E 104 -5.40%.

Description

Tablets are round, biconvex, yellow coated. The fracture is light yellow with splashes.

Pharmacotherapeutic group

Vitamin

ATX code

B03BB

Pharmacodynamics:

Vitamin B (vitamin B, vitamin B9) can be synthesized by the intestinal microflora. In the body, folic acid is reduced to tetrahydrofolic acid, which is a coenzyme involved in various metabolic processes. It is necessary for the normal maturation of megaloblasts and the formation of normoblasts. Stimulates erythropoiesis and participates in the synthesis of amino acids (including glycine methionine) of pyrimidine purines nucleic acids in the exchange of histidine choline.

Pharmacokinetics:

Folic acid is well and completely absorbed in the gastrointestinal tract, mainly in the upper duodenum. It binds almost completely to plasma proteins. It is activated in the liver under the influence of the enzyme dihydrofolate reductase, turning into tetrahydrofolic acid. The maximum concentration in blood plasma (Cmax) is reached after 30-60 minutes. Penetrates the blood-brain and placental barriers and enters breast milk.

It is excreted by the kidneys mainly in the form of metabolites; if the dose taken significantly exceeds the daily requirement for folic acid, it is excreted unchanged.

It is excreted using hemodialysis.

Indications:

  • Folic acid deficiency.

  • Prevention of the development of neural tube defects in the fetus in the first trimester of pregnancy.

Contraindications:

  • Hypersensitivity to the components that make up the drug;

  • pernicious anemia

  • malignant neoplasms

  • cobalamin deficiency

  • childhood.

Pregnancy and lactation:

Folic acid is necessary during preparation for pregnancy (1-3 months before the planned pregnancy) and in the first few weeks after conception (I trimester).

Method of administration and dosage:

Administered orally after meals.

With a deficiency of folic acid - 400 mcg (1 tab) per day.

For the prevention of the development of neural tube defects in the fetus in the 1st trimester of pregnancy - 400 mcg - 800 mcg (1-2 tablets).

Side effects:

Allergic reactions (skin rash, itching, bronchospasm, erythema, hyperthermia); from the gastrointestinal tract: nausea bloating, bitterness in the mouth, anorexia.

With prolonged use, hypovitaminosis B12 may develop.

Overdose:

It can occur with prolonged intake (more than 1-2 months) of folic acid in doses over 1000 mcg per day and as a result of combined use with vitamin-mineral complexes.

Interaction:

Reduces the effect of phenytoin (an increase in its dose is required).

Analgesics (long-term therapy) anticonvulsants (including phenytoin and carbamazepine) estrogens oral contraceptives increase the need for folic acid.

Antacids cholestyramine sulfonamines (including sulfasalazine) reduce the absorption of folic acid.

Methotrexate pyrimethamine triamterene trimethoprim inhibit dihydrofolate reductase and reduce the effect of folic acid (instead of it, patients using these drugs should be prescribed calcium folinate).

With simultaneous use with chloramphenicol neomycin polymyxins tetracycline, the absorption of folic acid is reduced.

Special instructions:

For the prevention of hypovitaminosis, a balanced diet is most preferable. Folic acid rich foods - green vegetables (salad spinach tomatoes carrots) fresh liver legumes beets eggs cheese nuts cereals.

Folic acid is not used to treat B12-deficiency (pernicious) normocytic and aplastic anemia, as well as anemia refractory to therapy. In case of pernicious (B 12-deficiency) anemia, folic acid, improving hematological parameters, masks neurological complications. Until pernicious anemia is ruled out, the administration of folic acid in doses exceeding 01 mg / day is not recommended (with the exception of pregnancy and lactation).

It should be borne in mind that patients on hemodialysis require increased amounts of folic acid.

During treatment, antacids should be used 2 hours after taking folic acid, cholestyramine - 4-6 hours before or 1 hour after taking folic acid. It should be borne in mind that antibiotics can distort (give deliberately underestimated values) the results of a microbiological assessment of the concentration of folic acid in plasma and erythrocytes. With the use of large doses of folic acid and therapy for a long period, a decrease in the concentration of vitamin B12 is possible.

Release form / dosage:

Film coated tablets 400 mcg.

Packaging:

On 10 tablets in a blister strip packaging or in a blister strip packaging with perforation from a film of polyvinyl chloride and printed aluminum foil varnished.

3 6 9 contour packs together with instructions for use are placed in a carton box.

Storage conditions:

In a dark place at a temperature not exceeding 25 ? C.

Keep out of the reach of children.

Shelf life:

3 years. Do not use after the expiration date.

Vacation conditions

Without recipe.

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