Foliber tablets 400 + 2mkg, No. 28
Expiration Date: 05/2027
Russian Pharmacy name:
Фолибер таблетки 400+2мкг, №28
Prevention of folic acid and vitamin B 12 deficiency in women of childbearing age at the stages of pregnancy planning (at least 1 month before conception).
Prevention of the development of neural tube defects in the fetus in the first trimester of pregnancy.
The drug should be taken 1 tablet a day before meals.
Active ingredients: folic acid (vit. Bc), cyanocobalamin (vit. B12)
Excipients: sodium carboxystarch type A, magnesium stearate, lactose monohydrate, microcrystalline cellulose, trisodium citrate, citric acid, maltodextrin.
Hypersensitivity to the components of the drug.
pharmachologic effect
Foliber is a complex of B vitamins.
Insufficiency of folic acid causes disturbances in DNA synthesis in a cell preparing for chromosome replication and division. The mechanism of action is due to the participation of folic acid in the form of tetrahydrofolate in the synthesis of nucleic acids and in cell division, as well as participation as a coenzyme in the synthesis of purines and pyrimidines, which makes it a decisive factor in the formation of the central nervous system, which develops in humans 15-28 days after fertilization ... The conversion of 5-methyltetrahydrofolate to tetrahydrofolate in the body can occur only as a result of the addition of a methyl group to homocysteine ??with the formation of methionine as a result of the action of methionine synthetase.
In this process, vitamin B 12 participates as a limiting cofactor, therefore, vitamin B 12 deficiency is similar in the effects of insufficient activation of folic acid; in addition, vitamin B 12 is also involved in the uptake of folic acid by cells, so when a cell experiences a primary deficiency of vitamin B 12, it is also deficient in folate.
The pharmacological action of the drug Foliber is that its use allows you to overcome the metabolic blockade, which is observed in mothers of children with neural tube defects. The specific nature of this metabolic blockage lies in the metabolism of the essential amino acid methionine, in which folate and vitamin B12 are key elements as they are responsible for the re-methylation of homocysteine ??to methionine. 400 mcg of folic acid is the minimum effective daily dose recommended by the Centers for Disease Prevention (USA, UK, Australia) to healthy women as an additional daily intake to prevent the development of neural tube defects in the fetus.
The RDA for vitamin B 12 is 2 mcg.
Indications
Prevention of folic acid and vitamin B 12 deficiency in women of childbearing age at the stages of pregnancy planning (at least 1 month before conception).
Prevention of the development of neural tube defects in the fetus in the first trimester of pregnancy.
Contraindications
Hypersensitivity to the components of the drug.
Application during pregnancy and lactation
The drug is used during pregnancy according to indications.
Composition
Active ingredients: folic acid (vit. Bc), cyanocobalamin (vit. B12)
Excipients: sodium carboxystarch type A, magnesium stearate, lactose monohydrate, microcrystalline cellulose, trisodium citrate, citric acid, maltodextrin.
Method of administration and dosage
The drug should be taken 1 tablet a day before meals.
Drug interactions
Foliber should not be used in combination with methotrexate, as the latter acts as a folic acid antagonist by inhibiting the enzyme hydrofolate reductase.
With the simultaneous use of Foliber with antiepileptic drugs from the hydantoin group, it can reduce the effects of the latter.
Storage conditions
The drug should be stored in a dry place at a temperature not exceeding 25 ? C.