Folacin tablets 5mg, No. 30

- Treatment and prevention of folic acid deficiency in the presence of unbalanced or malnutrition;
- treatment and prevention of anemias associated with folic acid deficiency (macrocytic hyperchromic anemia, anemia and leukopenia caused by drugs and ionizing radiation, megaloblastic anemia, post-resection anemia, sideroblastic anemia in elderly patients, anemias associated with diseases of the small intestine, sprue and syndrome malabsorption);
- treatment and prevention of anemia during pregnancy and lactation (breastfeeding);
- to prevent the development of congenital malformations in the fetus (neural tube defects);
- with prolonged use of folic acid antagonists (methotrexate or a combination of sulfamethoxazole - trimethoprim), anticonvulsant therapy (phenytoin, primidone, phenobarbital).

Folacin is administered orally.

For the treatment of megaloblastic anemia caused by folic acid deficiency : 5 mg per day for 4 months, for prophylaxis - 2.5 mg per day.

For the prevention and treatment of macrocytic anemia in malabsorption, inflammatory bowel diseases and unbalanced or inadequate nutrition - 15 mg per day, for patients with sprue disease - 5-15 mg per day.

To prevent the development of neural tube defects in the fetus - 2.5 mg per day for 4 weeks before the expected pregnancy. Reception continues during the first trimester of pregnancy.

Higher maintenance doses of Folacin can be given to patients with alcoholism, as well as to patients with chronic infections and taking anticonvulsants.

1 tab. contains: folic acid 5 mg,
excipients: lactose monohydrate, povidone, crospovidone, microcrystalline cellulose, magnesium stearate

• Hypersensitivity to the components of the drug Folacin;

• pernicious anemia;

• malignant neoplasms;

• cobalamin deficiency.

pharmachologic effect

Folacin is a vitamin preparation. Vitamin B. Folic acid in the body is converted into tetrahydrofolic acid, as a coenzyme involved in various metabolic processes, and is necessary for the normal maturation of megaloblasts and the formation of normoblasts. With a deficiency of folic acid, a megaloblastic type of hematopoiesis develops. Folacin stimulates erythropoiesis, participates in the synthesis of amino acids (including methionine, serine, glycine), nucleic acids, purines, pyrimidines, in the exchange of choline, histidine. During pregnancy, it performs a protective function in relation to the action of teratogenic and fetal damaging factors. Folacin contributes to the normal maturation and function of the placenta.

Indications

- Treatment and prevention of folic acid deficiency in the presence of unbalanced or malnutrition;
- treatment and prevention of anemias associated with folic acid deficiency (macrocytic hyperchromic anemia, anemia and leukopenia caused by drugs and ionizing radiation, megaloblastic anemia, post-resection anemia, sideroblastic anemia in elderly patients, anemias associated with diseases of the small intestine, sprue and syndrome malabsorption);
- treatment and prevention of anemia during pregnancy and lactation (breastfeeding);
- to prevent the development of congenital malformations in the fetus (neural tube defects);
- with prolonged use of folic acid antagonists (methotrexate or a combination of sulfamethoxazole - trimethoprim), anticonvulsant therapy (phenytoin, primidone, phenobarbital).

Contraindications

• Hypersensitivity to the components of the drug Folacin;

• pernicious anemia;

• malignant neoplasms;

• cobalamin deficiency.

special instructions

Patients on hemodialysis require increased amounts of folic acid.
With prolonged use of folic acid, especially in high doses, a decrease in the concentration of vitamin B12 in the blood is possible.
Long-term use of the drug is recommended to be combined with the intake of vitamin B12 (cyanocobalamin).

Composition

1 tab. contains: folic acid 5 mg,
excipients: lactose monohydrate, povidone, crospovidone, microcrystalline cellulose, magnesium stearate

Method of administration and dosage

Folacin is administered orally.

For the treatment of megaloblastic anemia caused by folic acid deficiency : 5 mg per day for 4 months, for prophylaxis - 2.5 mg per day.

For the prevention and treatment of macrocytic anemia in malabsorption, inflammatory bowel diseases and unbalanced or inadequate nutrition - 15 mg per day, for patients with sprue disease - 5-15 mg per day.

To prevent the development of neural tube defects in the fetus - 2.5 mg per day for 4 weeks before the expected pregnancy. Reception continues during the first trimester of pregnancy.

Higher maintenance doses of Folacin can be given to patients with alcoholism, as well as to patients with chronic infections and taking anticonvulsants.

Side effects

From the digestive system: anorexia, nausea, bloating, bitterness in the mouth.
Allergic reactions: skin rash, itching, erythema, bronchospasm.

Storage conditions

In a dark place at a temperature not exceeding 25 ? C.