Fluditec syrup 5%, 125ml

acute and chronic bronchopulmonary diseases (tracheitis, bronchitis, tracheobronchitis, bronchial asthma, bronchiectasis) and inflammatory diseases of the nasal cavity, nasopharynx, paranasal sinuses and middle ear (rhinitis, adenoiditis, sinusitis, otitis media) accompanied by the formation of a viscous, difficult to separate , mucus);

preparation for bronchoscopy and / or bronchography.

For adults, the drug is prescribed at 750 mg (15 ml of syrup for adults) 3 times / day.

It should be borne in mind that 15 ml is contained in 1 tablespoon.

For children, Fluditec is prescribed in the form of a syrup for children.

100 ml of syrup contains:

active substance: carbocisteine ??5 g

excipients: sucrose, caramel flavor, glycerin, sodium hydroxide, yellow-orange dye S, purified water, dye proprietary blue preservative: methyl parahydroxybenzoate;

in glass bottles of 125 ml; in a cardboard box 1 bottle.

- peptic ulcer of the stomach and duodenum in the acute phase;

- chronic glomerulonephritis (in the acute phase), cystitis;

- children's age up to 2 years (for syrup 20 mg / ml for children) and up to 15 years (for syrup 50 mg / ml);

- I trimester of pregnancy (for syrup 50 mg / ml);

- hypersensitivity to carbocisteine ??or other components of Fluditec.

Care should be taken to prescribe the drug for chronic glomerulonephritis (history), gastric ulcer and duodenal ulcer (history).

Pharmacodynamics

Mucolytic and expectorant action

Fluditec is caused by the activation of sialic transferase - an enzyme of the goblet cells of the bronchial mucosa. Normalizes the quantitative ratio of acidic and neutral sialomucins of bronchial secretions, restores the viscosity and elasticity of mucus. Promotes the regeneration of the mucous membrane, normalizes its structure, activates the activity of the ciliated epithelium. Restores the secretion of immunologically active IgA (specific protection) and the amount of sulfhydryl groups of mucus components (non-specific protection), improves mucociliary clearance. Restores the secretion of immunologically active IgA (specific protection) and the amount of sulfhydryl groups of mucus components (non-specific protection).

Pharmacokinetics

After oral administration, Cmax in blood serum and in the mucous membrane of the respiratory tract is reached after 2-3 hours and remains in the mucous membrane for 8 hours. It is excreted mainly by the kidneys, partly - unchanged, partly - in the form of metabolites.

Interaction

With the simultaneous use of Fluditec increases the effectiveness of glucocorticosteroid (mutually) and antibacterial therapy for inflammatory diseases of the upper and lower respiratory tract. With the simultaneous use of Fluditec enhances the bronchodilator effect of theophylline. The activity of carbocisteine ??is weakened by antitussives and atropine-like drugs.

Overdose

Symptoms: gastralgia, nausea, diarrhea.

Treatment: symptomatic therapy.

special instructions

Fluiditec should be used with caution with a wet cough. For persons with gastric ulcer and duodenal ulcer, the drug is recommended to be prescribed with caution. The simultaneous use of Fluditek with antitussive drugs and / or substances that inhibit bronchial secretion (including atropine-like drugs) is not recommended. When prescribing the drug for concomitant diabetes mellitus, as well as for patients on a diet with a low sugar content, the sucrose content should be taken into account (5.25 g per tablespoon in syrup for adults and 3.5 g per teaspoon in syrup for children).

Fluditek indications for use - acute and chronic bronchopulmonary diseases, accompanied by the formation of viscous, difficult to separate sputum (tracheitis, bronchitis, tracheobronchitis, bronchial asthma, bronchiectasis); - acute and chronic inflammatory diseases of the nasal cavity, nasopharynx, paranasal sinuses and middle ear, accompanied by the formation of viscous, difficult to separate mucus (rhinitis, adenoiditis, sinusitis, otitis media); - preparation for bronchoscopy and / or bronchography.