Flixonase spray nasal dosage. 50mkg / dose 60 doses
Dosage:
50mcg / dose x 120dose
50mcg / dose x 60dose
Category
Runny nose
Scope of the medicinal product
Ear, Throat, Nose
Release form
Spray
Manufacturer country
Spain
Package quantity, pcs
one
Amount in a package
60 doses
Dosage form
nasal spray
Appointment
Antiallergic
Manufacturer
GlaxoSmithKline, Spain
Structure
Active ingredient: fluticasone propionate (micronized) 50 mcg
Excipients: anhydrous dextrose, microcrystalline cellulose, microcrystalline carboxymethyl cellulose, phenylethyl alcohol, benzalkonium chloride solution, polysorbate 80, diluted hydrochloric acid, purified water.
pharmachologic effect
FLIXONASE - anti-allergic, decongestant, anti-inflammatory.
The anti-inflammatory effect is realized as a result of the interaction of the drug with the GCS receptors.
Suppresses the proliferation of mast cells, eosinophils, lymphocytes, macrophages, neutrophils.
Fluticasone propionate reduces the production of inflammatory mediators and other biologically active substances (histamine, PG, leukotrienes, cytokines) during the early and late phases of an allergic reaction.
Restores the patient's reaction to bronchodilators, allowing to reduce the frequency of their use.
Reduces sneezing, itchy nose, runny nose, nasal congestion, sinus discomfort and pressure around the nose and eyes.
In addition, it relieves eye symptoms associated with allergic rhinitis.
Pharmacodynamics
It has a fast anti-inflammatory effect on the nasal mucosa, and its antiallergic effect appears within 2-4 hours after the first application.
A decrease in the severity of symptoms (especially nasal congestion) persists for 24 hours after a single injection of a spray at a dose of 200 μg.
Fluticasone propionate improves patients' quality of life, including physical and social activity.
When used in the recommended doses, it does not have any pronounced systemic activity and practically does not inhibit the hypothalamic-pituitary-adrenal system.
Pharmacokinetics
After intranasal administration of fluticasone propionate (200 μg / day), Cmax in plasma is not detected in most patients (i.e., it is less than 0.01 ng / ml). The highest Cmax is 0.017 ng / ml. Direct absorption on the nasal mucosa is negligible due to the low solubility of the drug in water, as a result of which most of the dose is ultimately swallowed. Less than 1% of the dose is absorbed from the gastrointestinal tract into the bloodstream due to poor absorption and presystemic metabolism. All this leads to the fact that the total absorption in the nasal cavity and the gastrointestinal tract (swallowed drug) is extremely low. When the equilibrium plasma concentration is reached, fluticasone propionate has a large volume of distribution (about 318 liters). It has a fairly high ability to bind to plasma proteins (91%).
Fluticasone propionate is rapidly excreted from plasma, mainly as a result of metabolism in the liver to an inactive carboxylic metabolite under the action of the cytochrome P450 isoenzyme CYP3A4.
Swallowed fluticasone propionate is extensively metabolized as a result of its primary passage through the liver.
The main route of elimination is the excretion of fluticasone propionate and its metabolites in the bile.
Indications
Regular therapy of bronchial asthma
allergic rhinitis, eczema
psoriasis
neurodermatitis.
Contraindications
Hypersensitivity to Fliksonase.
Side effects
Local reactions: dryness and irritation of the nasopharynx, unpleasant taste and smell, nosebleeds, burning sensation, nasal congestion
very rarely (less than 1/10 000 cases) - perforation of the nasal septum (especially with a history of surgical interventions in the nasal cavity).
Allergic reactions: possible skin rash, swelling of the face and tongue
very rarely (less than 1/10 000 cases) - anaphylactic reactions and bronchospasm.
Others: headache.
Very rare cases of glaucoma, increased intraocular pressure and cataracts have been reported.
Name ENG
FLIXONASE
Clinical and pharmacological group
GCS for intranasal use
ATX code
Fluticasone
Dosage
50mcg / dose x 60dose
Structure
Active ingredient: fluticasone propionate (micronized) 50 mcg
Excipients: anhydrous dextrose, microcrystalline cellulose, microcrystalline carboxymethyl cellulose, phenylethyl alcohol, benzalkonium chloride solution, polysorbate 80, diluted hydrochloric acid, purified water.
Indications
Seasonal and perennial allergic rhinitis (prevention and treatment).
Storage conditions and periods
At a temperature not higher than 30 degrees.
Expiration date: 3 years
INN / Active ingredient
Fluticasone
Specifications
Category
Runny nose
Scope of the medicinal product
Ear, Throat, Nose
Release form
Spray
Manufacturer country
Spain
Package quantity, pcs
one
Scope of application
Allergology
Minimum age from
4 years old
Way of introduction
Intranasally
Vacation conditions
Without recipe
Brand name
Fliksonase
The amount of the dosage form in the primary package
60 dose
Primary packaging type
Bottle
Type of consumer packaging
Pack of cardboard
Pharmaco-therapeutic group
Topical glucocorticosteroid
Anatomical and therapeutic characteristics
R01AD08 Fluticasone
Dosage form
Dosed nasal spray
Expiration date in days
1095
Dosage (volume) of the substance in the preparation
fluticasone propionate (micronized) - 50 mcg
The target audience
Children
Package weight, g
twenty
Mode of application
:
Flixonase is intended for intranasal use only. To achieve the full therapeutic effect, the drug should be used regularly. < br> For the prevention and treatment of seasonal allergic rhinitis and perennial allergic rhinitis, adults and children over 12 years of age are prescribed 100 μg (2 doses) in each nostril 1 time / day (total dose 200 μg / day), preferably in the morning. After symptom control is achieved, 50 μg (1 dose) can be administered to each nostril 1 time / day (total dose 100 μg / day). < br> In some cases, it is required to apply 100 mcg (2 doses) in each nostril 2 times / day (total dose 400 mcg / day) for a short time in order to achieve control of symptoms, after which the dose can be reduced. The maximum daily dose of the drug is 400 mcg (4 doses in each nostril). < br> Elderly patients do not require dosage adjustment. < br> For children aged 4-12 years for the prevention and treatment of seasonal allergic rhinitis, it is recommended to prescribe 50 mcg (1 dose) in each nostril 1 time / day. The maximum daily dose of the drug is 200 mcg (2 doses in each nostril). < br> The maximum therapeutic effect appears after 3-4 days of therapy. To achieve the full therapeutic effect, the drug must be used regularly.The maximum therapeutic effect is manifested after 3-4 days of therapy. To achieve the full therapeutic effect, the drug must be used regularly.The maximum therapeutic effect is manifested after 3-4 days of therapy. To achieve the full therapeutic effect, the drug must be used regularly.
Information on technical characteristics, delivery set, country of manufacture