Ferrovir solution for injection 1.5%, 5ml No. 5

Ferrovir is used in combination therapy of HIV-infected patients and AIDS patients, HIV-infected patients with hepatitis C, HIV-infected patients with recurrent herpes infection. In the treatment of patients with tick-borne encephalitis, hepatitis C, herpes.

In the treatment of HIV infection or AIDS, the drug is prescribed for adults intramuscularly: 5 ml (15 mg / ml) of a solution for intramuscular administration (75 mg in terms of dry matter) 2 times a day (150 mg) for 14 days. If necessary, a second course of therapy is prescribed after 1-1.5 months.

In the treatment of herpes - 5 ml (15 mg / ml) solution for intramuscular injection 2 times a day for 10 days.

In the treatment of hepatitis C, Ferrovir is administered intramuscularly 2 times a day, 5 ml (15 mg / ml) of a solution for intramuscular administration for 14 days. In the next 14 days, the drug is administered in the same daily dose every other day.

With tick-borne encephalitis, the drug is administered 2 times a day, 5 ml (15 mg / ml) of a solution for intramuscular administration for 5-10 days.

When using an intramuscular solution of 2 ml, recalculate until the course dose of 750-2100 mg is reached.

Active substance: 1 ml of solution contains sodium deoxyribonucleate 0.015 g and 0.000048 g of iron oxide chloride.
Excipient: water for injection.

Individual intolerance.

Pregnancy and lactation,

childhood.

Trade name of the drug: Ferrovir.

Chemical name: Sodium deoxyribonucleate with iron complex

Dosage form:

solution for intramuscular injection

Composition:
Active substance: 1 ml of solution contains 0.015 g of sodium deoxyribonucleate and 0.000048 g of iron oxide chloride.
Excipient: water for injection.

Description: transparent liquid of yellow color without foreign inclusions.

Pharmacotherapeutic group:

immunomodulatory and antiviral agent.

ATX code: J05AX.

Pharmacological properties
Pharmacodynamics
Ferrovir is a biologically active substance - an extract from the milk of sturgeon or salmon fish (purified and standardized complex salt of sodium deoxyribonucleate with iron). The drug has antiviral and immunomodulatory effects, activates antiviral, antifungal and antimicrobial immunities. Shows antiviral action against various RNA and DNA viruses. Clinical experience with the drug has shown its high activity, good tolerance, lack of toxicity (IC50> 4000mkg / ml), and unwanted side effects. In the treatment of AIDS / HIV infection, a 14-day course of use of Ferrovir increases the level of CD4 + lymphocytes in the blood. This increase continues for 1-1.5 months after the end of the course of treatment. At the same time, the viral load in the body decreases,expressed in a decrease in the concentration of HIV RNA in comparison with the initial level. With recurrent herpes infection, the severity and duration of the relapse is reduced, and a quick and long-term remission occurs after a 10-day course of treatment. The use of Ferrovir in the complex treatment of patients with chronic hepatitis C contributes to the improvement of treatment tolerance (reduction of dizziness, nausea, etc.), a decrease in the replicative activity of all genotypes of the HCV virus, the transfer of the process to a latent phase with the restoration of liver cells and the absence of viral replication. The drug is characterized by a high degree of activity in the joint presence of viruses of the underlying and opportunistic diseases. The chemotherapeutic index of the drug is more than 20, which is typical for highly active drugs.

Pharmacokinetics
When the recommended dose is administered intramuscularly, the drug is rapidly absorbed and distributed in organs and tissues with the participation of the endolymphatic pathway of transport; has a high tropism to the organs of the hematopoietic system; takes an active part in cellular metabolism, integrating into cellular structures. In the process of daily course use, it has the property of cumulating in organs and tissues. The time to reach the maximum concentration with a single administration is 0.5 hour, after which the concentration of the drug in the blood begins to decrease, associated with its distribution in organs and tissues. With repeated administration of the drug every 24 hours for 4 days, its greatest accumulation is observed in the spleen, lymph nodes and bone marrow. After the 5th injection, the concentration of the drug during subsequent injections in all organs and tissues does not increase,its gradual decrease is observed.

Metabolism and excretion
The drug is excreted from the body (in the form of metabolites), partly with feces and, to a greater extent, with urine. The average retention time of the drug in organs and tissues is 72 hours. The half-life is 36 hours.

Indications for use
Ferrovir is used in combination therapy of HIV-infected patients and AIDS patients, HIV-infected patients with hepatitis C, HIV-infected patients with recurrent herpes infection. In the treatment of patients with tick-borne encephalitis, hepatitis C, herpes.

Contraindications
Individual intolerance.

Pregnancy and lactation,

childhood.

Dosage and administration
In the treatment of HIV infection or AIDS, the drug is prescribed for adults intramuscularly: 5 ml (15 mg / ml) solution for intramuscular injection (75 mg in terms of dry matter) 2 times a day (150 mg), for 14 days ... If necessary, a second course of therapy is prescribed after 1-1.5 months.

In the treatment of herpes - 5 ml (15 mg / ml) solution for intramuscular injection 2 times a day for 10 days.

In the treatment of hepatitis C, Ferrovir is administered intramuscularly 2 times a day, 5 ml (15 mg / ml) of a solution for intramuscular administration for 14 days. In the next 14 days, the drug is administered in the same daily dose every other day.

With tick-borne encephalitis, the drug is administered 2 times a day, 5 ml (15 mg / ml) of a solution for intramuscular administration for 5-10 days.

When using an intramuscular solution of 2 ml, recalculate until the course dose of 750-2100 mg is reached.

Side effect
Possible short-term increase in body temperature (up to 38 ? C), hyperemia and moderate pain at the injection site.

Overdose
Negative effects from overdose have not been identified.

Interaction with other medicinal products
Moderately potentiates the effect of anticoagulants.

In complex therapy, it reduces the toxicity and negative effects of the drugs used (headache, nausea, etc.)

Special instructions
To reduce pain, Ferrovir is administered intramuscularly slowly, within 1-2 minutes.

The solution for injection should be completely used immediately after opening the vial; storage of open vials is not allowed.

Intravenous administration of the drug is not allowed!

Release form
Solution for intramuscular administration of 15 mg / ml in vials of 2 ml, 5 ml from neutral or dark glass.

Original packaging of 5 vials of 5 ml or 10 vials of 2 ml in a pallet-blister with instructions in a cardboard box.

Storage conditions
In the dark place at temperatures from + 4 ? C to + 20 ? C. Keep out of the reach of children.

Shelf life is
5 years. Do not use the drug after the expiration date printed on the package.

Terms of dispensing from pharmacies
Dispensed by prescription.

Manufacturer / Organization accepting claims
CJSC FP Technomedservice, Russia.
105318, Moscow, st. Mironovskaya, 33