Exoderil solution for external use. approx. 1%, 10ml

Fungal infections of the skin and skin folds (tinea corporis, tinea inguinalis), incl.

• interdigital mycoses (tinea manum, tinea pedum);

• fungal infections of the nails (onychomycosis);

• candidiasis of the skin;

• pityriasis versicolor;

• dermatomycosis (with or without accompanying itching).

  ExoderilЃ is effective in the treatment of mycoses affecting areas of the skin with hyperkeratosis, as well as in areas of hair growth. '

Outwardly.

ExoderilЃ is applied once a day to the affected skin surface and adjacent areas (approximately 1 cm of healthy skin along the edges of the affected area) after thorough cleaning and drying. The duration of therapy for dermatomycosis is 2-4 weeks (if necessary - up to 8 weeks), with candidiasis - 4 weeks.

In case of nail damage, ExoderilЃ is applied 2 times a day to the affected nail.

Before the first use of the drug, the affected part of the nail is removed as much as possible with scissors or a nail file. The duration of therapy for onychomycosis is up to 6 months.

To prevent relapse, treatment should be continued for at least 2 weeks after the disappearance of clinical symptoms.

1 ml of solution contains:

active substance: naftifine hydrochloride - 10 mg;

excipients: propylene glycol - 50 mg, ethanol - 400 mg, purified water - 475 mg.

• Hypersensitivity to naftifine or propylene glycol;

• pregnancy and lactation (safety and efficacy have not been determined).

• Application of the drug to the wound surface is contraindicated.

Pharmacological action
Naftifine is an antifungal agent for external use, belonging to the class of allylamines. The mechanism of action is associated with inhibition of squalene-2,3-epoxidase, which leads to a decrease in the formation of ergosterol, which is part of the cell wall of the fungus. It is active against dermatophytes such as trichophyton, epidermophyton and microsporum, molds (Aspergillus spp.), Yeasts (Candida spp., Pityrosporum) and other fungi (eg Sporothrix schenckii). In relation to dermatophytes and aspergillus, naftifine has a fungicidal effect. In relation to yeast fungi, the drug exhibits fungicidal or fungistatic activity, depending on the strain of the microorganism.
Side effects
In some cases, local reactions can be observed: dry skin, skin flushing and burning. Side effects are reversible and do not require treatment withdrawal.
Overdose
Cases of overdose are unknown.