Ethoxidol injection 50mg / ml, 2ml No. 10

• acute disorders of cerebral circulation;

• encephalopathy;

• vegetative dystonia syndrome;

• mild cognitive disorders of atherosclerotic genesis;

• anxiety disorders in neurotic and neurosis-like states;

• relief of withdrawal symptoms in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders;

• acute intoxication with antipsychotic drugs.

EtoxidolЃ is prescribed intramuscularly and intravenously (jet or drip).

When administered by infusion, the drug should be diluted in 0.9% sodium chloride solution.

Doses are selected individually. Begin therapy with a dose of 50-100 mg 1-3 times / day, gradually increasing until a therapeutic effect is obtained.

In / in a jet, the drug is injected slowly over 5-7 minutes, drip - at a rate of 40-60 drops / min. The maximum daily dose should not exceed 800 mg.

In acute disorders of cerebral circulation, EtoxidolЃ is prescribed in complex therapy in the first 2-4 days intravenously (drip) at a dose of 200-300 mg, then 100 mg intramuscularly 3 times / day. The duration of treatment is 10-14 days.

In case of discirculatory encephalopathy in the decompensation phase - i.v. (jet or drip) at a dose of 100 mg 2-3 times / day for 14 days, then i / m 100 mg 2 times / day for 14 days.

For the course prevention of discirculatory encephalopathy - intramuscularly at a dose of 100 mg 2 times / day for 10-14 days.

With mild cognitive impairment in elderly patients and with anxiety disorders - intramuscularly in a daily dose of 100-300 mg / day for 14-30 days.

With alcohol withdrawal syndrome - i / m in a dose of 100-200 mg 2-3 times / day or i / v drip 1-2 times / day for 5-7 days.

In case of acute intoxication with antipsychotic drugs - intravenous in a dose of 50-300 mg / day for 7-14 days.

Active ingredient: ethylmethylhydroxypyridine malate - 50 mg

Excipients: acetylglutamic acid - 34 mg, deanol - 16 mg, glycine - 0.1 mg, disodium edetate - 0.5 mg, water d / i - up to 1 ml.

• pregnancy;

• lactation period;

• age under 18;

• hypersensitivity to the drug or its components.

With care: history of allergic diseases and reactions.

Clinical and pharmacological group: Antioxidant drug

Pharmaco-therapeutic group: Antioxidant

pharmachologic effect

EtoxidolЃ is an inhibitor of free radical processes, has a membrane-protective, antihypoxic, nootropic, anticonvulsant, anxiolytic effect, increases the body's resistance to stress.

EtoxidolЃ has anti-ischemic properties, improves blood flow in the ischemic zone, limits the zone of ischemic damage, exhibits a hypolipidemic effect, and reduces the content of total cholesterol and low density lipoproteins in the blood serum.

The drug increases the body's resistance to the effects of various damaging factors, to oxygen-dependent pathological conditions (shock, hypoxia and ischemia, cerebral circulation disorders, alcohol and antipsychotic drugs (neuroleptics) intoxication).

The drug improves cerebral metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, and reduces platelet aggregation. It stabilizes the membrane structures of blood cells (erythrocytes and platelets) during hemolysis.

The mechanism of action of the drug is due to its antioxidant, antihypoxic and membrane-protective action. It inhibits lipid peroxidation, increases the activity of superoxide oxidase, increases the lipid-protein ratio, reduces the viscosity of the membrane, and increases its fluidity. It modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps to preserve the structural and functional organization of biomembranes and transport of neuromembranes.

Pharmacokinetics

Suction

When administered intramuscularly, the drug is determined in blood plasma for 4 hours after administration. TCmax is 0.25 hours. Cmax when a dose of 100 mg is administered is 0.3-1.06 ?g / ml. EthoxidolЃ quickly passes from the bloodstream to organs and tissues and is quickly eliminated from the body. The retention time of the drug is 1.84-2.38 h.

Withdrawal

T1 / 2 is 1.15-1.75 hours. EthoxidolЃ is excreted from the body by the kidneys, mainly in the form of glucuronides and in small amounts unchanged.

Indications

• acute disorders of cerebral circulation;

• encephalopathy;

• vegetative dystonia syndrome;

• mild cognitive disorders of atherosclerotic genesis;

• anxiety disorders in neurotic and neurosis-like states;

• relief of withdrawal symptoms in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders;

• acute intoxication with antipsychotic drugs.

Dosage regimen

EtoxidolЃ is prescribed intramuscularly and intravenously (jet or drip).

When administered by infusion, the drug should be diluted in 0.9% sodium chloride solution.

Doses are selected individually. Begin therapy with a dose of 50-100 mg 1-3 times / day, gradually increasing until a therapeutic effect is obtained.

In / in a jet, the drug is injected slowly over 5-7 minutes, drip - at a rate of 40-60 drops / min. The maximum daily dose should not exceed 800 mg.

In acute disorders of cerebral circulation, EtoxidolЃ is prescribed in complex therapy in the first 2-4 days intravenously (drip) at a dose of 200-300 mg, then 100 mg intramuscularly 3 times / day. The duration of treatment is 10-14 days.

In case of discirculatory encephalopathy in the decompensation phase - i.v. (jet or drip) at a dose of 100 mg 2-3 times / day for 14 days, then i / m 100 mg 2 times / day for 14 days.

For the course prevention of discirculatory encephalopathy - intramuscularly at a dose of 100 mg 2 times / day for 10-14 days.

With mild cognitive impairment in elderly patients and with anxiety disorders - intramuscularly in a daily dose of 100-300 mg / day for 14-30 days.

With alcohol withdrawal syndrome - i / m in a dose of 100-200 mg 2-3 times / day or i / v drip 1-2 times / day for 5-7 days.

In case of acute intoxication with antipsychotic drugs - intravenous in a dose of 50-300 mg / day for 7-14 days.

Side effect

Possibly: dry and metallic taste in the mouth, sensations of 'spreading warmth' throughout the body, unpleasant odor, sore throat and chest discomfort, feeling of shortness of breath (usually associated with an excessively high injection rate and are short-lived) ; with prolonged use - nausea, flatulence; sleep disturbances (drowsiness or trouble falling asleep).

Contraindications for use

• pregnancy;

• lactation period;

• age under 18;

• hypersensitivity to the drug or its components.

With care: history of allergic diseases and reactions.

Application during pregnancy and lactation

EtoxidolЃ is contraindicated during pregnancy and lactation, because strictly controlled clinical studies of the safety of the drug during pregnancy and lactation have not been conducted.

Application in children

Contraindicated in children under 18 years of age.

Use in elderly patients

With mild cognitive impairment in elderly patients and with anxiety disorders - intramuscularly in a daily dose of 100-300 mg / day for 14-30 days.

special instructions

Influence on the ability to drive vehicles and use mechanisms

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Overdose

Symptoms: sleep disturbances (insomnia, in some cases drowsiness); with the on / in the introduction - a slight and short-term (up to 1.5-2 hours) increase in blood pressure.

Treatment: As a rule, not required - symptoms disappear on their own within 24 hours. In severe cases of insomnia - nitrazepam 10 mg, oxazepam 10 mg or diazepam 5 mg. With an excessive increase in blood pressure - antihypertensive drugs under the control of blood pressure.

Drug interactions

Enhances the effect of benzodiazepine anxiolytics, anticonvulsants (carbamazepine), antiparkinsonian drugs (levodopa).

Reduces the toxic effects of ethyl alcohol.

Storage conditions

The drug should be stored in a dry, dark place, out of the reach of children, at a temperature not exceeding 25 ? C.

Shelf life

Shelf life is 2 years.

Do not use after the expiration date.

Terms of sale

The drug is available with a prescription.

Contacts for inquiries

SYNTHESIS OJSC JOINT STOCK KURGAN SOCIETY OF MEDICAL PREPARATIONS AND PRODUCTS (Russia)