Esslial Forte capsules 300mg, No. 30 Ozone

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BIDL3179051
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Expiration Date: 05/2027

Russian Pharmacy name:

Эсслиал форте капсулы 300мг, №30 Озон

Esslial Forte capsules 300mg, No. 30 Ozone

  • chronic hepatitis;

  • cirrhosis of the liver;

  • fatty degeneration of the liver of various etiologies;

  • toxic liver damage;

  • alcoholic hepatitis;

  • liver dysfunction in other somatic diseases;

  • toxicosis of pregnancy;

  • prevention of recurrence of the formation of gallstones;

  • psoriasis (as an adjuvant therapy);

  • radiation syndrome.

Inside. The capsules should be taken whole with plenty of water (about 1 glass).

For adolescents over 12 years old and weighing more than 43 kg, as well as for adults, Esslial Forte is recommended to take 2 capsules - 3 times / day with meals.

As a rule, the duration of use is not limited.

lipoid PPL-400 400 mg, which corresponds to the content of polyunsaturated phospholipids from soy lecithin (PPL fraction) * 300 mg

  • individual intolerance to phosphatidylcholine or auxiliary components of the drug;

  • soy intolerance;

  • children under 12 years of age (lack of sufficient evidence).

pharmachologic effect

Essential phospholipids are the main elements of the structure of the cell membrane and cell organelles of the liver. In liver diseases, there is always damage to the membranes of the liver cells and their organelles, which leads to disruptions in the activity of enzymes and receptor systems associated with them, deterioration of the functional activity of liver cells and a decrease in the ability to regenerate. The phospholipids that make up the Esslial Forte preparation correspond in their chemical structure to endogenous phospholipids, but surpass endogenous phospholipids in activity due to their higher content of polyunsaturated (essential) fatty acids. The incorporation of these high-energy molecules into the damaged areas of the cell membranes of hepatocytes restores the integrity of the liver cells and promotes their regeneration.The cis-double bonds of their polyunsaturated fatty acids prevent the parallel arrangement of hydrocarbon chains in the phospholipids of the cell walls, the density of the phospholipid structure of the cell walls of hepatocytes decreases, which leads to an increase in their fluidity and elasticity, and improves metabolism. The resulting functional blocks increase the activity of enzymes fixed on the membranes and contribute to the normal physiological pathway of the most important metabolic processes. Phospholipids, which are part of Esslial Forte, regulate lipoprotein metabolism, transferring neutral fats and cholesterol to oxidation sites, mainly by increasing the ability of HDL to bind to cholesterol. Thus, there is a normalizing effect on the metabolism of lipids and proteins;on the detoxification function of the liver and phospholipid-dependent enzyme systems; which ultimately prevents the formation of connective tissue in the liver and promotes the natural regeneration of liver cells. When phospholipids are excreted into bile, the lithogenic index decreases and bile stabilizes.

Pharmacokinetics

More than 90% of phospholipids taken orally are absorbed in the small intestine. Most of them are cleaved by phospholipase A to 1-acyl-lysophosphatidylcholine, 50% of which immediately undergoes reverse acetylation to polyunsaturated phosphatidylcholine during the absorption process in the intestinal mucosa. This polyunsaturated phosphatidylcholine enters the bloodstream with the lymph flow, and from there, mainly in the form associated with HDL, enters the liver. Pharmacokinetic studies in humans were carried out using radiolabeled dilinoleyl phosphatidylcholine (3H and 14C). The choline part was labeled with 3H, and the linoleic acid residue was labeled with 14C. Cmax 3H is achieved 6-24 hours after administration and is 19.9% ??of the prescribed dose. T1 / 2 of the choline component is 66 hours. Cmax 14C is reached 4-12 hours after administration and is up to 27.9% of the prescribed dose. T1 / 2 of this component is 32 hours. Both isotopes are absorbed by more than 90% in the intestine.

Side effect

Esslial Forte is usually well tolerated by patients. In order to estimate the frequency of side effects, the following definitions are used: very often (> 1/10), often (> 1 / 100- <1/10), infrequently (> 1/1000 - <1/100), rarely (> 1 / 10,000- <1/1000), very rare (<1/10,000), unknown frequency (the frequency of occurrence cannot be determined from the available data). From the gastrointestinal tract: rarely - discomfort in the epigastric region, loosening of the stool, nausea, gastralgia. Allergic reactions: very rarely - rash, exanthema, urticaria; unknown frequency - itching.

Application during pregnancy and lactation

May be used during pregnancy according to indications.

special instructions

Influence on the ability to drive vehicles and mechanisms Does not affect.

Overdose

There is no information.

Drug interactions

There is no information.

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