Eskuzan oral solution, 20 ml

Chronic venous insufficiency of varicose and post-thrombotic genesis and its complications, incl. diseases associated with functional impairment of blood supply:

• swelling, cramps in the calf muscles;

• pain and feeling of heaviness in the legs;

• phlebeurysm;

• hemorrhoids.

Assign inside 12-15 drops 3 times / day.

The drug should be taken before meals with a small amount of liquid.

Shake the contents of the bottle before taking the drug.

Active ingredients:

dry extract of horse chestnut seeds (5-7: 1) - 4.725 g

thiamine hydrochloride - 500 mg

Excipients: ethanol 96% - 26.4 g, purified water - 67.675 g, lactose monohydrate - 432 mg, colloidal silicon dioxide 243 g.

Extractant: ethanol 60 vol.%

• hypersensitivity to the components of the drug.

Clinical and pharmacological group: Phytopreparation used for disorders of venous circulation

Pharmaco-therapeutic group: Herbal venotonic agent

pharmachologic effect

The drug used for disorders of venous circulation. Contains horse chestnut fruit extract, has anti-exudative, venotonic effect. It was found that horse chestnut fruit extract reduces the concentration of lysosomal enzymes, as a result of which the disintegration of mucopolysaccharides in the region of the capillary walls decreases. Aescusan reduces vascular permeability, preventing the filtration of low molecular weight proteins, electrolytes and water into the extracellular space. In randomized double-blind and crossover studies, there was a decrease in transcapillary filtration and a significant decrease in edema, a decrease in the feeling of heaviness, fatigue, tension, itching, pain.

Pharmacokinetics

Absorption and distribution

After oral administration of 50 mg of horse chestnut fruit extract, Cmax in blood plasma is reached after 2.35 hours and is 25.31 ng / ml.

Plasma protein binding is 84%.

Withdrawal

T1 / 2 is 19.87 hours. After oral administration, 0.11% of horse chestnut extract is excreted by the kidneys in the form of escin.

Indications

Chronic venous insufficiency of varicose and post-thrombotic genesis and its complications, incl. diseases associated with functional impairment of blood supply:

• swelling, cramps in the calf muscles;

• pain and feeling of heaviness in the legs;

• phlebeurysm;

• hemorrhoids.

Dosage regimen

Assign inside 12-15 drops 3 times / day.

The drug should be taken before meals with a small amount of liquid.

Shake the contents of the bottle before taking the drug.

Side effect

Rarely: rarely - irritation of the gastrointestinal mucosa.

Contraindications for use

• hypersensitivity to the components of the drug.

Application during pregnancy and lactation

There are clinical data on the use of Aescusan during pregnancy in patients with varicose veins and peripheral venous edema.

Aescuzan should be used with caution during lactation, because the product contains ethanol.

special instructions

The preparation contains 31% by volume ethanol.

With prolonged storage, the solution may become cloudy and a precipitate forms, which does not affect the effectiveness of the drug.

Overdose

To date, no cases of drug overdose have been reported.

Drug interactions

The effect of thiamine, which is part of the drug Eskuzan, decreases when used simultaneously with sulfite-containing infusion solutions.

Storage conditions

The drug should be stored at temperatures between 8 ? and 25 ? C; do not freeze.

Shelf life

Shelf life is 3 years.

Terms of sale

The drug is approved for use as a means of OTC.

Contacts for inquiries

QUAYSSER PHARMA GMBH & CO. KG (Germany)