Erythromycin eye ointment 10000ED, 10g

Special Price $16.66 Regular Price $24.00
In stock
SKU
BIDL3181862
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Expiration Date: 11/2025

Russian Pharmacy name:

Эритромициновая глазная мазь 10000ЕД, 10г

Erythromycin eye ointment 10000ED, 10g

Infectious and inflammatory eye diseases caused by sensitive microorganisms:

conjunctivitis (including in newborns),

body blepharitis,

blepharoconjunctivitis,

meibomite;

as part of the complex therapy of bacterial keratitis, chlamydial conjunctivitis, blepharoconjunctivitis, trachoma;

Prevention of neonatal blennorrhea.

Applied topically - the drug is placed in the lower eyelid. The dose, frequency and duration of use are determined individually.

Eye ointment

1 g

erythromycin 10,000 units

  • History of jaundice

  • severe violations of liver and kidney function,

  • hypersensitivity to macrolides.

  • With caution Elderly patients, mild to moderate hepatic and renal dysfunction.

pharmachologic effect

Antibiotic of the macrolide group. Has a bacteriostatic effect. However, in high doses, it has a bactericidal effect against sensitive microorganisms. Erythromycin reversibly binds to bacterial ribosomes, thereby inhibiting protein synthesis. Effective against sensitive microorganisms that cause superficial eye infections of the corneal conjunctiva, incl. for Neisseria gonorrhoeae, Chlamydia trachomatis.

Pharmacokinetics

Absorbed into the cornea and aqueous humor of the eye. When applied topically, the therapeutic concentration of erythromycin in the tissues of gdase is achieved, systemic absorption is low. In case of damage to the corneal epithelium, the effective concentration of erythromycin in the moisture of the anterior chamber is achieved 30 minutes after application. Bioavailability is 30-65%. Distributed in most tissues and body fluids. Plasma protein binding is 70-90%. It is metabolized in the liver, partly with the formation of inactive metabolites. T1 / 2 - 1.4-2 hours. It is excreted through the intestines and kidneys.

Side effect

Local reactions: hyperemia, irritation of the mucous membrane of the eye, blurred vision, allergic reactions.

Application during pregnancy and lactation

Erythromycin crosses the placental barrier and is excreted in breast milk. When using erythromycin during pregnancy, the intended benefit to the mother and the potential risk to the fetus should be assessed. If necessary, use during lactation should decide on the termination of breastfeeding.

Application for violations of liver function

Contraindicated with a history of jaundice, severe liver dysfunction. Use with caution for violations of liver function.

Application for impaired renal function

Use is contraindicated in severe renal impairment.

Application in children

Application is possible according to the dosage regimen.

Use in elderly patients

Use with caution in elderly patients.

special instructions

In children whose mothers have clinically expressed gonorrhea, erythromycin as an ophthalmic drug is used simultaneously with an aqueous solution of penicillin G for parenteral use.

Drug interactions

Shows antagonism with lincomycin, clindamycin and chloramphenicol. Reduces the bactericidal effect of beta-lactam antibiotics (penicillins, cephalosporins, carbapenems). Pharmaceutically incompatible with aminoglycosides. When used with GCS, it leads to an increase in their effect.

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