Enrostin 10ml

DESCRIPTION

Enrostin (Enrostin) is a veterinary drug with a therapeutic purpose in calves, lambs, pigs and poultry for respiratory and gastrointestinal diseases. In appearance, the drug is a clear or slightly opalescent liquid from light yellow to bright yellow in color.

COMPOSITION

Enrostin as active ingredients in 1 ml contains: enrofloxacin - 100 mg and colistin sulfate - 106 IU, as well as auxiliary substances: benzyl alcohol, sodium metabisulfite, lactic acid, syntanol and purified water.

PHARMACOLOGICAL PROPERTIES

Enrostin belongs to the antibacterial drugs of the fluoroquinolone group in combination.

Enrofloxacin, which is part of the drug, belongs to the compounds of the fluoroquinolone group, the mechanism of action of which is based on inhibition of the activity of the enzyme gyrase, which affects the replication of the DNA helix in the nucleus of a bacterial cell, which leads to suppression of the growth and development of gram-positive and gram-negative bacteria, including Escherichia coli , Haemophilus spp., Pasteurella spp., Salmonella spp., Staphylococcus spp., Streptococcus spp., Clostridium perfringens, Bordetella spp., Campylobacter spp., Corynebacterium pyogenes, Pseudomonas aeruginosa, and also Mycoplasma spp.

Colistin sulfate is a polypeptide antibiotic, disrupting the permeability of the bacterial cell wall by combining with lipoproteins, causing changes in intracellular metabolism and the death of gram-negative bacteria, including Escherichia coli, Pseudomonas aeruginosa, Klebsiella spp., Salmonella spp., Proteus spp.

The combination of enrofloxacin and colistin sulfate, having a synergistic effect, provides a wide range of antimicrobial activity of the drug.

After oral administration of the drug, enrofloxacin is well and quickly absorbed in the gastrointestinal tract and penetrates into most organs and tissues; excreted from the body unchanged and partly in the form of metabolites, mainly in the urine and in small quantities with feces; Colistin sulfate is practically not absorbed in the gastrointestinal tract, does not accumulate in organs and tissues, and is excreted from the body mainly unchanged with feces.

According to the degree of impact on the body, Enrostin belongs to moderately hazardous substances (hazard class 3 according to GOST 12.1.007-76), in recommended doses it is well tolerated by animals, does not have embryotoxic and teratogenic properties.

PURPOSE

Enrostin is prescribed for therapeutic purposes in calves, lambs, pigs and poultry for respiratory and gastrointestinal diseases, colibacillosis, salmonellosis, streptococcosis, necrotic enteritis, hemophilia, mycoplasmosis and other infections, the causative agents of which are sensitive to enrofloxinacia.

DOSAGE AND APPLICATION

Enrostin is administered to animals orally once a day for 3-5 days, in the following doses: calves, lambs individually, pigs individually or in groups - 0.3 ml / kg of animal weight, drinking with water for drinking at a dilution of 1: 1; in severe disease, the daily dose of the drug is increased to 0.5 ml / kg of animal weight; broiler chickens, replacement chickens up to 14 weeks of age, broiler breeders and meat turkeys - 0.5 ml / l of water for drinking.

With salmonellosis, mixed infections, as well as with chronic forms of bird diseases, the course of treatment is extended to 7 days.

During the treatment period, pigs and poultry should only receive water containing the medicinal product. The medicinal solution is prepared daily in a volume calculated for consumption by animals during the day.

SPECIAL INSTRUCTIONS

When working with Enrostin, you should follow the general rules of personal hygiene and safety measures provided for when working with medicinal products. At the end of work, hands should be washed with warm water and mouse. In case of accidental contact of the drug with the skin or mucous membranes of the eye, they should be immediately washed with plenty of water. People with hypersensitivity to the drug components should avoid direct contact with Enrostin. In case of allergic reactions or accidental ingestion of the drug into the human body, you should immediately contact a medical institution (you should have instructions for the use of the drug or a label with you).

Empty vials from under the medicinal product must not be used for domestic purposes, they must be disposed of with household waste.

It is not allowed to use the drug in sows during pregnancy and breastfeeding.

In case of an overdose of the drug, the animal may experience a decrease in appetite, depression, vomiting, diarrhea.

Enrostin should not be used simultaneously with chloramphenicol, macrolides, tetracyclines, theophylline, polyester ionophores, non-steroidal anti-inflammatory drugs, drugs containing magnesium, aluminum and calcium cations, which, by binding to enrofloxacin, prevent its adsorption.

CONTRAINDICATIONS

A contraindication to use is the animal's hypersensitivity to the components of the drug. It is forbidden to use the drug Enrostin in laying hens and replacement hens less than 2 weeks before the start of oviposition, due to the accumulation of enrofloxacin in the eggs. It is not allowed to use the drug Enrostin in adult ruminants with developed cicatricial digestion, piglets weighing less than 20 kg, animals with severe disorders of the development of cartilage tissue, severe kidney and / or liver diseases, with lesions of the nervous system, accompanied by convulsions.

SIDE EFFECTS

When using the drug Enrostin in accordance with this instruction, side effects and complications are usually not observed.

With increased individual sensitivity of the animal to the components of the drug

Enrostin and the appearance of side effects and complications, the use of the drug is stopped and desensitizing therapy is performed.

SHELF LIFE AND STORAGE

The shelf life of the medicinal product, subject to storage conditions in the manufacturer's sealed packaging, is 2 years from the date of production, after opening the bottle - 28 days.

Store the drug in the manufacturer's closed packaging, protected from direct sunlight, separately from food and feed, at a temperature of 5 В° C to 25 В° C.

PACKAGING

Enrostin is produced packaged: 1 ml each in polymer dropper bottles complete with screw caps and dropper stoppers, or in glass bottles sealed with rubber stoppers and rolled up with aluminum caps.

Specifications

Bonus points

0

KolVUP

ten

Manufacturer

APICENNA

Temperature regime

from 0 to +25

Teaser

prescribed for medicinal purposes in calves, lambs, pigs and poultry for respiratory and gastrointestinal diseases