Endokol-T 1l

DESCRIPTION

Endocol-T (Endocolum-T) is a complex antimicrobial drug for the prevention of postpartum diseases of the uterus and treatment of endometritis. In appearance, the drug is a clear liquid from light yellow to yellow.

COMPOSITION

1.0 ml of the drug contains 90,000 U of colistin sulfate, 10,000 U of tylosin tartrate, 1.7 mg of propranolol hydrochloride, auxiliary substances and a solvent up to 1.0 ml.

PHARMACOLOGICAL PROPERTIES

Endokol-T is a complex antimicrobial drug.

Tylosin tartrate, which is part of the drug, has a bacteriostatic effect against gram-positive bacteria: Staphylococcus spp., Streptococcus spp., Corinebacterium spp., And some gram-negative microorganisms: Pasteurella spp., Leptospira spp., As well as Rickettsia spp., Mycoplasma spp., Mycoplasma spp. , Chlamydia spp. Tylosin tartrate blocks protein synthesis of microorganisms at the ribosome level.

Colistin sulfate is active against many gram-negative microorganisms, including Escherichia coli, Pseudomonas aeruginosa, Klebsiella spp., Salmonella spp., Corynebacterium spp., Clostridium spp., Pasteurella spp., Bacteroides spp., Erysoplothia rhus. The mechanism of the bactericidal action of colistin is the destruction of the structure of the phospholipids of the cell membrane, which causes the death of the microorganism.

Propranolol hydrochloride enhances the contractility of the myometrium, which contributes to a faster separation of the placenta, and with endometritis - the removal of purulent contents from the uterus.

The substances included in the preparation are poorly absorbed by the uterine mucosa, which prevents their accumulation in various organs and tissues of animals.

In recommended doses, it does not have a local irritant, resorptive-toxic, mutagenic and sensitizing effect.

DOSAGE AND APPLICATION

Endokol-T is used in cows for the prevention of postpartum diseases of the uterus and treatment of endometritis.

Before the introduction of the drug, the external genital organs are treated. If necessary, empty the uterine cavity from the contents.

When treating animals with various forms of endometritis, the drug is administered intrauterinely at a dose of 50.0 - 150.0 ml using a Janet syringe with an interval of 24 - 48 hours until clinical recovery. The course of treatment is 3 - 5 injections. In chronic and subclinical endometritis, rectal massage of the uterus should be performed for 1.5 - 2 minutes before the administration of the drug.

For the prevention of postpartum diseases, the drug is used once intrauterinely at a dose of 50.0 - 150.0 ml with the help of Janet's syringe after separation of the placenta, abortion or assistance in complications and pathological childbirth.

Avoid skipping the next dose of the drug, as this can lead to a decrease in therapeutic effectiveness.

SPECIAL INSTRUCTIONS

Simultaneous use of the drug with drugs containing xylazine, medetomidine and detomidine is not allowed.

Milk obtained from animals during the treatment period and within three days after the last use of the drug should not be used for food purposes. Slaughter of animals for meat is allowed no earlier than four days after the last use of the drug. The meat of animals that were forcedly killed before the expiration of the specified period can be used for feeding fur-bearing animals.

CONTRAINDICATIONS

The use of the drug is contraindicated in animals with increased individual sensitivity to the components of the drug.

SIDE EFFECTS

Allergic reactions are possible when using the drug. If they occur, the drug should be discontinued and antihistamines (allervet, diprazine) and calcium preparations (calcium gluconate or calcium chloride) should be used.

SHELF LIFE AND STORAGE

The drug is stored according to list B in a dry, dark place at a temperature from plus 5 В° C to plus 25 В° C. The shelf life of the drug is 1 year from the date of manufacture, subject to the rules of storage and transportation.

PACKAGING

The drug is produced in a plastic container with a volume of 1000 ml.

Specifications

KolVUP

12

Manufacturer

Belarus

Temperature regime

from +5 to +25

Teaser

for the prevention of postpartum diseases of the uterus and treatment of endometritis