Elkar effervescent granules 1000mg, No. 10

The drug is used as part of complex therapy in adults:

With intense and prolonged physical exertion, psychoemotional stress: to increase performance, endurance, reduce fatigue, including in the elderly;

Ј During the period of rehabilitation after diseases and surgical interventions, injuries, including to accelerate tissue regeneration;

With anorexia nervosa;

In diseases accompanied by a lack of carnitine or its increased loss (myopathy, cardiomyopathy, mitochondrial diseases, hereditary diseases with concomitant mitochondrial insufficiency): to compensate for its deficiency as part of complex therapy;

In sports medicine and during intense training (during the training process when working out aerobic performance): to improve speed-strength indicators and coordination of movements, to increase muscle mass and reduce body fat mass, to prevent post-training syndrome (accelerate recovery processes after physical exertion ), with traumatic injuries in order to accelerate muscle regeneration.

The drug is used as part of complex therapy in adults.

Inside 30 minutes before meals. The contents of the sachet are dissolved in 100-200 ml of water at room temperature (15-25 ? C) and taken immediately after preparation.

1 sachet contains 1000 mg (1 g) of levocarnitine.

With intense and prolonged physical activity, psychoemotional stress: 1-2 g (1-2 sachets) 3 times a day.

With anorexia nervosa, as well as during the rehabilitation period after diseases and surgical interventions, injuries, including to accelerate tissue regeneration: 1 g (1 sachet) 3 times a day. The course of treatment is within 1-2 months.

In diseases accompanied by a lack of carnitine or its increased loss (myopathy, cardiomyopathy, mitochondrial diseases, hereditary diseases with concomitant mitochondrial insufficiency): up to 50-100 mg / kg body weight with a frequency of taking 2-3 times a day up to 7 g (7 sachets ) per day. The course of treatment is within 3-4 months.

In sports medicine and with intensive training: from 1 g (1 sachet) 3 times a day to 2 g (2 sachets) 2-3 times a day (daily dose 3-6 g); in the case of medical use - 70-100 mg / kg / day (5-7 g / day). Reception course: 3-4 weeks in the pre-competition period. During the training process - up to 6-8 weeks.

1 sachet contains:

active substance : levocarnitine 1000.0 mg;

excipients : anhydrous citric acid 2750.0 mg, anhydrous sodium carbonate 1100.0 mg, lemon flavor 100.0 mg, acesulfame potassium 35.0 mg, anhydrous colloidal silicon dioxide 15.0 mg.

Individual intolerance to the components of the drug, age up to 18 years.

Application during pregnancy and during breastfeeding

Due to the lack of sufficient research, the use of the drug during pregnancy and during breastfeeding is not recommended.

Trade name:

ElkarЃ

International non-proprietary name:

levocarnitine

Chemical name:

(3R) -3-hydroxy-4- (trimethylammonio) butanoate

Dosage form:

effervescent granules for preparation of oral solution.

Composition:

1 sachet contains:

active substance : levocarnitine 1000.0 mg;

excipients : anhydrous citric acid 2750.0 mg, anhydrous sodium carbonate 1100.0 mg, lemon flavor 100.0 mg, acesulfame potassium 35.0 mg, anhydrous colloidal silicon dioxide 15.0 mg.

Description:

white or white with a yellowish tinge granules with a faint lemon odor; after dissolution of granules, a colorless or with a yellowish tinge, slightly opalescent solution with a weak lemon odor is formed.

Pharmacotherapeutic group:

metabolic agent

ATX code:

A16AA01

Pharmacological properties

Pharmacodynamics

Levocarnitine is a natural substance related to vitamins of group B. It participates in metabolic processes as a carrier of long-chain fatty acids (palmitic, etc.) from the cytoplasm to mitochondria, where these acids undergo the process of ?-oxidation with the formation of adenosine triphosphoric acid and acetyl-CoA.

Improves protein and fat metabolism, increases the secretion and enzymatic activity of gastric and intestinal juices, improves the absorption of food, reduces excess body weight and reduces muscle fat. Increases resistance to physical stress, inhibits the formation of keto acids and anaerobic glycolysis, reduces the degree of lactic acidosis, promotes economical consumption of glycogen and increases its reserves in the liver and muscles.

It has anabolic and lipolytic effects. Normalizes increased basal metabolism in hyperthyroidism: it is a peripheral (indirect) antagonist of the action of thyroid hormones, and not a direct inhibitor of thyroid function.

Improves metabolism and energy supply to tissues.

Pharmacokinetics

It is well absorbed in the intestines, the concentration in the blood plasma reaches a maximum after 3 hours and remains in the therapeutic range for 9 hours. Easily penetrates the liver, myocardium, more slowly - into the muscles. It is excreted by the kidneys, mainly in the form of acyl esters.

Indications for use

The drug is used as part of complex therapy in adults:

With intense and prolonged physical exertion, psychoemotional stress: to increase performance, endurance, reduce fatigue, including in the elderly;

Ј During the period of rehabilitation after diseases and surgical interventions, injuries, including to accelerate tissue regeneration;

With anorexia nervosa;

In diseases accompanied by a lack of carnitine or its increased loss (myopathy, cardiomyopathy, mitochondrial diseases, hereditary diseases with concomitant mitochondrial insufficiency): to compensate for its deficiency as part of complex therapy;

In sports medicine and during intense training (during the training process when working out aerobic performance): to improve speed-strength indicators and coordination of movements, to increase muscle mass and reduce body fat mass, to prevent post-training syndrome (accelerate recovery processes after physical exertion ), with traumatic injuries in order to accelerate muscle regeneration.

Contraindications

Individual intolerance to the components of the drug, age up to 18 years.

Application during pregnancy and during breastfeeding

Due to the lack of sufficient research, the use of the drug during pregnancy and during breastfeeding is not recommended.

Method of administration and dosage

The drug is used as part of complex therapy in adults.

Inside 30 minutes before meals. The contents of the sachet are dissolved in 100-200 ml of water at room temperature (15-25 ? C) and taken immediately after preparation.

1 sachet contains 1000 mg (1 g) of levocarnitine.

With intense and prolonged physical activity, psychoemotional stress: 1-2 g (1-2 sachets) 3 times a day.

With anorexia nervosa, as well as during the period of rehabilitation after diseases and surgical interventions, injuries, including to accelerate tissue regeneration: 1 g (1 sachet) 3 times a day. The course of treatment is within 1-2 months.

In diseases accompanied by a lack of carnitine or its increased loss (myopathy, cardiomyopathy, mitochondrial diseases, hereditary diseases with concomitant mitochondrial insufficiency): up to 50-100 mg / kg body weight with a frequency of taking 2-3 times a day up to 7 g (7 sachets ) per day. The course of treatment is within 3-4 months.

In sports medicine and with intensive training: from 1 g (1 sachet) 3 times a day to 2 g (2 sachets) 2-3 times a day (daily dose 3-6 g); in the case of medical use - 70-100 mg / kg / day (5-7 g / day). Reception course: 3-4 weeks in the pre-competition period. During the training process - up to 6-8 weeks.

Side effect

Adverse reactions that may occur during the use of the drug are classified as very rare (<1/10000 prescriptions):

disorders of the nervous system: very rare - myasthenic disorders (in patients with uremia);

disorders of the gastrointestinal tract: very rare - gastralgia, dyspepsia;

disorders of the skin and subcutaneous tissues: very rare - rash, allergic dermatitis.

If any of the adverse reactions indicated in the instructions are aggravated, or you notice any other adverse reactions not listed in the instructions, inform your doctor.

Overdose

Symptoms: dyspeptic disorders, myasthenic disorders (in patients with uremia).

Treatment: gastric lavage, intake of activated carbon.

Interaction

Glucocorticosteroids promote the accumulation of the drug in tissues (except for the liver), other anabolic steroids enhance the effect.

Influence of a medicinal product for medical use on the ability to drive vehicles, mechanisms

The drug does not affect the performance of potentially hazardous activities that require special attention and quick reactions (driving a car and other vehicles, working with moving mechanisms, the work of a dispatcher and an operator, etc.).

Release form

Effervescent granules for preparation of oral solution 1000 mg.

5 g of granules are placed in a heat-sealable bag made of multilayer material (paper / polyethylene / aluminum / polyethylene).

10 or 30 individual or paired sachets together with instructions for use are placed in a carton box.

Storage conditions

Store in a dry, dark place at a temperature not exceeding 25 ? C.

Keep out of the reach of children.

Shelf life

3 years.

Do not use after the expiration date.

Vacation conditions

Available without a prescription.